Relationship of hippocampal sclerosis to duration and age of onset of epilepsy, and childhood febrile seizures in temporal lobectomy patients
Controversy exists as to whether hippocampal sclerosis (HS) is a preexisting cause or a consequence of seizures. We investigated 122 consecutive patients who underwent anterior temporal lobectomy for intractable epilepsy between 1989 and 1992. MRI scans were normal apart from evidence of HS in 5 cas...
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| Veröffentlicht in: | Epilepsy research 1996-06, Vol.24 (2), p.119-126 |
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| creator | Davies, Keith G. Hermann, Bruce P. Dohan, F.Curtis Foley, Kevin T. Bush, Andrew J. Wyler, Allen R. |
| description | Controversy exists as to whether hippocampal sclerosis (HS) is a preexisting cause or a consequence of seizures. We investigated 122 consecutive patients who underwent anterior temporal lobectomy for intractable epilepsy between 1989 and 1992. MRI scans were normal apart from evidence of HS in 5 cases. The degree of HS was graded from 0 to 4. There was a significant inverse correlation between age of seizure onset and grade of HS (
P < 0.0001), and a positive correlation between duration of epilepsy and grade of HS (
P < 0.001). Using a dichotomous grouping of HS (HPSC − for grades 0 and 1 [no/mild HS], and HPSC + for grades 3 and 4 [moderate/marked HS]), there was a positive correlation between HPSC + and a history of childhood febrile seizures (CFS) (
P = 0.003), earlier age of onset of epilepsy (
P < 0.001) and longer duration epilepsy (
P < 0.001). There was no correlation with history of particularly prolonged individual seizures. Partial correlations after controlling for age at onset of epilepsy showed that there was no longer a significant relationship between HPSC + and duration of epilepsy. After controlling for duration of epilepsy, the relationship between HPSC + and age of onset remained significant (
P < 0.001). The correlation between HPSC + and CFS, controlling for age at onset, was not significant. A series of logistic regression analyses showed age at onset to be the only predictor of HPSC +. It is concluded that this is supportive evidence for preexisting HS being a cause of temporal lobe epilepsy and not a consequence of seizures |
| doi_str_mv | 10.1016/0920-1211(96)00008-3 |
| format | Article |
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P < 0.0001), and a positive correlation between duration of epilepsy and grade of HS (
P < 0.001). Using a dichotomous grouping of HS (HPSC − for grades 0 and 1 [no/mild HS], and HPSC + for grades 3 and 4 [moderate/marked HS]), there was a positive correlation between HPSC + and a history of childhood febrile seizures (CFS) (
P = 0.003), earlier age of onset of epilepsy (
P < 0.001) and longer duration epilepsy (
P < 0.001). There was no correlation with history of particularly prolonged individual seizures. Partial correlations after controlling for age at onset of epilepsy showed that there was no longer a significant relationship between HPSC + and duration of epilepsy. After controlling for duration of epilepsy, the relationship between HPSC + and age of onset remained significant (
P < 0.001). The correlation between HPSC + and CFS, controlling for age at onset, was not significant. A series of logistic regression analyses showed age at onset to be the only predictor of HPSC +. It is concluded that this is supportive evidence for preexisting HS being a cause of temporal lobe epilepsy and not a consequence of seizures</description><identifier>ISSN: 0920-1211</identifier><identifier>EISSN: 1872-6844</identifier><identifier>DOI: 10.1016/0920-1211(96)00008-3</identifier><identifier>PMID: 8796360</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Age of Onset ; Child ; Electroencephalography ; Epilepsy ; Epilepsy - physiopathology ; Febrile seizure ; Female ; Hippocampal sclerosis ; Hippocampus - pathology ; Hippocampus - physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Regression Analysis ; Sclerosis ; Seizures, Febrile - physiopathology ; Temporal Lobe - physiology ; Temporal Lobe - surgery ; Temporal lobectomy ; Treatment Outcome</subject><ispartof>Epilepsy research, 1996-06, Vol.24 (2), p.119-126</ispartof><rights>1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-60cc22346b5ebe0b22f89763d087f4517b8118cd133b75767150a3e7dd408eaf3</citedby><cites>FETCH-LOGICAL-c423t-60cc22346b5ebe0b22f89763d087f4517b8118cd133b75767150a3e7dd408eaf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0920121196000083$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8796360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davies, Keith G.</creatorcontrib><creatorcontrib>Hermann, Bruce P.</creatorcontrib><creatorcontrib>Dohan, F.Curtis</creatorcontrib><creatorcontrib>Foley, Kevin T.</creatorcontrib><creatorcontrib>Bush, Andrew J.</creatorcontrib><creatorcontrib>Wyler, Allen R.</creatorcontrib><title>Relationship of hippocampal sclerosis to duration and age of onset of epilepsy, and childhood febrile seizures in temporal lobectomy patients</title><title>Epilepsy research</title><addtitle>Epilepsy Res</addtitle><description>Controversy exists as to whether hippocampal sclerosis (HS) is a preexisting cause or a consequence of seizures. We investigated 122 consecutive patients who underwent anterior temporal lobectomy for intractable epilepsy between 1989 and 1992. MRI scans were normal apart from evidence of HS in 5 cases. The degree of HS was graded from 0 to 4. There was a significant inverse correlation between age of seizure onset and grade of HS (
P < 0.0001), and a positive correlation between duration of epilepsy and grade of HS (
P < 0.001). Using a dichotomous grouping of HS (HPSC − for grades 0 and 1 [no/mild HS], and HPSC + for grades 3 and 4 [moderate/marked HS]), there was a positive correlation between HPSC + and a history of childhood febrile seizures (CFS) (
P = 0.003), earlier age of onset of epilepsy (
P < 0.001) and longer duration epilepsy (
P < 0.001). There was no correlation with history of particularly prolonged individual seizures. Partial correlations after controlling for age at onset of epilepsy showed that there was no longer a significant relationship between HPSC + and duration of epilepsy. After controlling for duration of epilepsy, the relationship between HPSC + and age of onset remained significant (
P < 0.001). The correlation between HPSC + and CFS, controlling for age at onset, was not significant. A series of logistic regression analyses showed age at onset to be the only predictor of HPSC +. It is concluded that this is supportive evidence for preexisting HS being a cause of temporal lobe epilepsy and not a consequence of seizures</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Child</subject><subject>Electroencephalography</subject><subject>Epilepsy</subject><subject>Epilepsy - physiopathology</subject><subject>Febrile seizure</subject><subject>Female</subject><subject>Hippocampal sclerosis</subject><subject>Hippocampus - pathology</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Regression Analysis</subject><subject>Sclerosis</subject><subject>Seizures, Febrile - physiopathology</subject><subject>Temporal Lobe - physiology</subject><subject>Temporal Lobe - surgery</subject><subject>Temporal lobectomy</subject><subject>Treatment Outcome</subject><issn>0920-1211</issn><issn>1872-6844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kdFqFTEQhoMo9bT6Bgq5EgW3Jptskr0RpFgVCgXR65BNZj2R7CYmu4XjO_jOZnsOvWxuJuH_5h_yD0KvKLmkhIoPpG9JQ1tK3_biHalHNewJ2lEl20Yozp-i3QPyHJ2X8rsyknB-hs6U7AUTZIf-fYdgFh_nsvcJxxHXkqI1UzIBFxsgx-ILXiJ2a74HsZkdNr9gg2sbLNsFkg-QyuH9vWr3Prh9jA6PMOSq4AL-75qhYD_jBaYUc7UPcQC7xOmAU3WGeSkv0LPRhAIvT_UC_bz-_OPqa3Nz--Xb1aebxvKWLY0g1rYt42LoYAAytO2oeimYI0qOvKNyUJQq6yhjg-ykkLQjhoF0jhMFZmQX6M3RN-X4Z4Wy6MkXCyGYGeJatFSMdpyrCvIjaGsOJcOoU_aTyQdNid62oLeI9Rax7utj24Jmte31yX8dJnAPTafYq_7xqEP95J2HrIutAVhwPtdItIv-8QH_ARpImMc</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>Davies, Keith G.</creator><creator>Hermann, Bruce P.</creator><creator>Dohan, F.Curtis</creator><creator>Foley, Kevin T.</creator><creator>Bush, Andrew J.</creator><creator>Wyler, Allen R.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960601</creationdate><title>Relationship of hippocampal sclerosis to duration and age of onset of epilepsy, and childhood febrile seizures in temporal lobectomy patients</title><author>Davies, Keith G. ; Hermann, Bruce P. ; Dohan, F.Curtis ; Foley, Kevin T. ; Bush, Andrew J. ; Wyler, Allen R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-60cc22346b5ebe0b22f89763d087f4517b8118cd133b75767150a3e7dd408eaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Child</topic><topic>Electroencephalography</topic><topic>Epilepsy</topic><topic>Epilepsy - physiopathology</topic><topic>Febrile seizure</topic><topic>Female</topic><topic>Hippocampal sclerosis</topic><topic>Hippocampus - pathology</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Regression Analysis</topic><topic>Sclerosis</topic><topic>Seizures, Febrile - physiopathology</topic><topic>Temporal Lobe - physiology</topic><topic>Temporal Lobe - surgery</topic><topic>Temporal lobectomy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davies, Keith G.</creatorcontrib><creatorcontrib>Hermann, Bruce P.</creatorcontrib><creatorcontrib>Dohan, F.Curtis</creatorcontrib><creatorcontrib>Foley, Kevin T.</creatorcontrib><creatorcontrib>Bush, Andrew J.</creatorcontrib><creatorcontrib>Wyler, Allen R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davies, Keith G.</au><au>Hermann, Bruce P.</au><au>Dohan, F.Curtis</au><au>Foley, Kevin T.</au><au>Bush, Andrew J.</au><au>Wyler, Allen R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of hippocampal sclerosis to duration and age of onset of epilepsy, and childhood febrile seizures in temporal lobectomy patients</atitle><jtitle>Epilepsy research</jtitle><addtitle>Epilepsy Res</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>24</volume><issue>2</issue><spage>119</spage><epage>126</epage><pages>119-126</pages><issn>0920-1211</issn><eissn>1872-6844</eissn><abstract>Controversy exists as to whether hippocampal sclerosis (HS) is a preexisting cause or a consequence of seizures. We investigated 122 consecutive patients who underwent anterior temporal lobectomy for intractable epilepsy between 1989 and 1992. MRI scans were normal apart from evidence of HS in 5 cases. The degree of HS was graded from 0 to 4. There was a significant inverse correlation between age of seizure onset and grade of HS (
P < 0.0001), and a positive correlation between duration of epilepsy and grade of HS (
P < 0.001). Using a dichotomous grouping of HS (HPSC − for grades 0 and 1 [no/mild HS], and HPSC + for grades 3 and 4 [moderate/marked HS]), there was a positive correlation between HPSC + and a history of childhood febrile seizures (CFS) (
P = 0.003), earlier age of onset of epilepsy (
P < 0.001) and longer duration epilepsy (
P < 0.001). There was no correlation with history of particularly prolonged individual seizures. Partial correlations after controlling for age at onset of epilepsy showed that there was no longer a significant relationship between HPSC + and duration of epilepsy. After controlling for duration of epilepsy, the relationship between HPSC + and age of onset remained significant (
P < 0.001). The correlation between HPSC + and CFS, controlling for age at onset, was not significant. A series of logistic regression analyses showed age at onset to be the only predictor of HPSC +. It is concluded that this is supportive evidence for preexisting HS being a cause of temporal lobe epilepsy and not a consequence of seizures</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>8796360</pmid><doi>10.1016/0920-1211(96)00008-3</doi><tpages>8</tpages></addata></record> |
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| ispartof | Epilepsy research, 1996-06, Vol.24 (2), p.119-126 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Age of Onset Child Electroencephalography Epilepsy Epilepsy - physiopathology Febrile seizure Female Hippocampal sclerosis Hippocampus - pathology Hippocampus - physiopathology Humans Magnetic Resonance Imaging Male Regression Analysis Sclerosis Seizures, Febrile - physiopathology Temporal Lobe - physiology Temporal Lobe - surgery Temporal lobectomy Treatment Outcome |
| title | Relationship of hippocampal sclerosis to duration and age of onset of epilepsy, and childhood febrile seizures in temporal lobectomy patients |
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