Pharmacokinetics of Diltiazem in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis
The disposition of a single oral dose of diltiazem hydrochloride was studied in six male patients treated by continuous ambulatory peritoneal dialysis. Peak concentrations were obtained 2 to 4 hours postdose. The mean absorption rate constant was 0.94 ± 0.21 (sd) hr‐1, and the mean elimination half‐...
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| Veröffentlicht in: | Journal of clinical pharmacology 1988-05, Vol.28 (5), p.477-480 |
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| container_title | Journal of clinical pharmacology |
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| creator | Grech-Bélanger, Odette Langlois, Serge LeBoeuf, Elizabeth |
| description | The disposition of a single oral dose of diltiazem hydrochloride was studied in six male patients treated by continuous ambulatory peritoneal dialysis. Peak concentrations were obtained 2 to 4 hours postdose. The mean absorption rate constant was 0.94 ± 0.21 (sd) hr‐1, and the mean elimination half‐life was 3.09 ± 1.16 hr. Serum levels of deacetyldiltiazem, a metabolite of diltiazem, were always below 10 ng/mL. The amounts of diltiazem and deacetyldiltiazem eliminated in dial ysate over 24 hours represent less than 0.1% of the administered dose. The pharmacokinetic parameters of diltiazem determined in these patients did not differ from those determined in healthy volunteers and in patients suffering from end‐stage renal disease. |
| doi_str_mv | 10.1002/j.1552-4604.1988.tb05763.x |
| format | Article |
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Peak concentrations were obtained 2 to 4 hours postdose. The mean absorption rate constant was 0.94 ± 0.21 (sd) hr‐1, and the mean elimination half‐life was 3.09 ± 1.16 hr. Serum levels of deacetyldiltiazem, a metabolite of diltiazem, were always below 10 ng/mL. The amounts of diltiazem and deacetyldiltiazem eliminated in dial ysate over 24 hours represent less than 0.1% of the administered dose. The pharmacokinetic parameters of diltiazem determined in these patients did not differ from those determined in healthy volunteers and in patients suffering from end‐stage renal disease.</description><identifier>ISSN: 0091-2700</identifier><identifier>EISSN: 1552-4604</identifier><identifier>DOI: 10.1002/j.1552-4604.1988.tb05763.x</identifier><identifier>PMID: 3392246</identifier><identifier>CODEN: JCPCBR</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Antianginal agents. Coronary vasodilator agents ; Biological and medical sciences ; Cardiovascular system ; Diltiazem - pharmacokinetics ; Half-Life ; Humans ; Intestinal Absorption ; Kidney Failure, Chronic - metabolism ; Kidney Failure, Chronic - therapy ; Male ; Medical sciences ; Middle Aged ; Peritoneal Dialysis, Continuous Ambulatory ; Pharmacology. 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Peak concentrations were obtained 2 to 4 hours postdose. The mean absorption rate constant was 0.94 ± 0.21 (sd) hr‐1, and the mean elimination half‐life was 3.09 ± 1.16 hr. Serum levels of deacetyldiltiazem, a metabolite of diltiazem, were always below 10 ng/mL. The amounts of diltiazem and deacetyldiltiazem eliminated in dial ysate over 24 hours represent less than 0.1% of the administered dose. The pharmacokinetic parameters of diltiazem determined in these patients did not differ from those determined in healthy volunteers and in patients suffering from end‐stage renal disease.</description><subject>Adult</subject><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Diltiazem - pharmacokinetics</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Kidney Failure, Chronic - metabolism</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Peritoneal Dialysis, Continuous Ambulatory</subject><subject>Pharmacology. Drug treatments</subject><issn>0091-2700</issn><issn>1552-4604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1u1DAUhS0EKtPCIyBFCLFLsOO_hBVloFNQBbOgYoflJDfF08QutqPO8PQ4mmj2yAvbOueee_Qh9JrggmBcvtsVhPMyZwKzgtRVVcQGcylosX-CVifpKVphXJO8lBg_R-ch7DAmgnFyhs4orcuSiRX6tf2t_ahbd28sRNOGzPXZJzNEo__CmBmbbXU0YGPIbm0H_s4Ze5etnY3GTm4K2eXYTIOOzh-yLXgTnQU9pAQ9HIIJL9CzXg8BXi73Bbq9-vxjfZ3ffN98WV_e5C2jFc2rnvZl3bP0aVrZVZ2UdQc1g4bgkvak7igVXDecVWLuzQkQwIxiAbwEIegFenvMffDuzwQhqtGEFoZBW0gtlawoYayskvH90dh6F4KHXj14M2p_UASrGa7aqZmgmgmqGa5a4Kp9Gn61bJmaEbrT6EIz6W8WXYdWD73XtjXhZJOE1LhmyfbhaHs0Axz-o4D6ut5ez88UkR8jTIiwP0Vof6-EpJKrn982ilYfrzbpKEL_AWOYplg</recordid><startdate>198805</startdate><enddate>198805</enddate><creator>Grech-Bélanger, Odette</creator><creator>Langlois, Serge</creator><creator>LeBoeuf, Elizabeth</creator><general>Blackwell Publishing Ltd</general><general>Sage Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198805</creationdate><title>Pharmacokinetics of Diltiazem in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis</title><author>Grech-Bélanger, Odette ; Langlois, Serge ; LeBoeuf, Elizabeth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4383-8f3f29f4438bc7d8d779de94eb1023f19d3365ab5486224651e1e04306e52e663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Antianginal agents. Coronary vasodilator agents</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Diltiazem - pharmacokinetics</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>Kidney Failure, Chronic - metabolism</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Peritoneal Dialysis, Continuous Ambulatory</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grech-Bélanger, Odette</creatorcontrib><creatorcontrib>Langlois, Serge</creatorcontrib><creatorcontrib>LeBoeuf, Elizabeth</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grech-Bélanger, Odette</au><au>Langlois, Serge</au><au>LeBoeuf, Elizabeth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of Diltiazem in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis</atitle><jtitle>Journal of clinical pharmacology</jtitle><addtitle>J Clin Pharmacol</addtitle><date>1988-05</date><risdate>1988</risdate><volume>28</volume><issue>5</issue><spage>477</spage><epage>480</epage><pages>477-480</pages><issn>0091-2700</issn><eissn>1552-4604</eissn><coden>JCPCBR</coden><abstract>The disposition of a single oral dose of diltiazem hydrochloride was studied in six male patients treated by continuous ambulatory peritoneal dialysis. Peak concentrations were obtained 2 to 4 hours postdose. The mean absorption rate constant was 0.94 ± 0.21 (sd) hr‐1, and the mean elimination half‐life was 3.09 ± 1.16 hr. Serum levels of deacetyldiltiazem, a metabolite of diltiazem, were always below 10 ng/mL. The amounts of diltiazem and deacetyldiltiazem eliminated in dial ysate over 24 hours represent less than 0.1% of the administered dose. The pharmacokinetic parameters of diltiazem determined in these patients did not differ from those determined in healthy volunteers and in patients suffering from end‐stage renal disease.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3392246</pmid><doi>10.1002/j.1552-4604.1988.tb05763.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-2700 |
| ispartof | Journal of clinical pharmacology, 1988-05, Vol.28 (5), p.477-480 |
| issn | 0091-2700 1552-4604 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiovascular system Diltiazem - pharmacokinetics Half-Life Humans Intestinal Absorption Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - therapy Male Medical sciences Middle Aged Peritoneal Dialysis, Continuous Ambulatory Pharmacology. Drug treatments |
| title | Pharmacokinetics of Diltiazem in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis |
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