Termination of second trimester pregnancy with gemeprost and misoprostol: A randomized double-blind placebo-controlled trial
A prospective randomized double-blind placebo-controlled trial was conducted in 70 subjects to determine whether pre-treatment with misoprostol could facilitate termination of second trimester pregnancy by gemeprost. The women received either 400 μg oral misoprostol or placebo tablets 12 hours befor...
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| Veröffentlicht in: | Contraception (Stoneham) 1996-07, Vol.54 (1), p.23-25 |
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| container_title | Contraception (Stoneham) |
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| creator | Wong, K.S. Ngai, C.S.W. Chan, K.S. Tang, L.C.H. Ho, P.C. |
| description | A prospective randomized double-blind placebo-controlled trial was conducted in 70 subjects to determine whether pre-treatment with misoprostol could facilitate termination of second trimester pregnancy by gemeprost. The women received either 400 μg oral misoprostol or placebo tablets 12 hours before the administration of vaginal pessary of gemeprost 1 mg every 3 hours. There were no significant differences in induction-abortion interval and the amount of gemeprost required between the misoprostol and the placebo group. There was no significant difference in the incidence of side effects or analgesic requirement between the two groups. We conclude that oral misoprostol is not useful in facilitating termination of second trimester pregnancy by gemeprost. |
| doi_str_mv | 10.1016/0010-7824(96)00115-1 |
| format | Article |
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The women received either 400 μg oral misoprostol or placebo tablets 12 hours before the administration of vaginal pessary of gemeprost 1 mg every 3 hours. There were no significant differences in induction-abortion interval and the amount of gemeprost required between the misoprostol and the placebo group. There was no significant difference in the incidence of side effects or analgesic requirement between the two groups. We conclude that oral misoprostol is not useful in facilitating termination of second trimester pregnancy by gemeprost.</description><identifier>ISSN: 0010-7824</identifier><identifier>EISSN: 1879-0518</identifier><identifier>DOI: 10.1016/0010-7824(96)00115-1</identifier><identifier>PMID: 8804804</identifier><identifier>CODEN: CCPTAY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Abortion, Induced ; Administration, Intravaginal ; Administration, Oral ; Adolescent ; Adult ; Alprostadil - administration & dosage ; Alprostadil - adverse effects ; Alprostadil - analogs & derivatives ; Biological and medical sciences ; Birth control ; Double-Blind Method ; Female ; gemeprost ; Gynecology. Andrology. Obstetrics ; Humans ; Induced abortion. Therapeutic abortion ; Medical sciences ; Misoprostol - administration & dosage ; Misoprostol - adverse effects ; oral misoprostol ; Placebos ; Population ; Pregnancy ; Pregnancy Trimester, Second ; second trimester termination</subject><ispartof>Contraception (Stoneham), 1996-07, Vol.54 (1), p.23-25</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-f7bc99cc70c18d7e35bef1de4239549ed8ffbb350446f1e19d2d75444eb226833</citedby><cites>FETCH-LOGICAL-c386t-f7bc99cc70c18d7e35bef1de4239549ed8ffbb350446f1e19d2d75444eb226833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0010-7824(96)00115-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3128311$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8804804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, K.S.</creatorcontrib><creatorcontrib>Ngai, C.S.W.</creatorcontrib><creatorcontrib>Chan, K.S.</creatorcontrib><creatorcontrib>Tang, L.C.H.</creatorcontrib><creatorcontrib>Ho, P.C.</creatorcontrib><title>Termination of second trimester pregnancy with gemeprost and misoprostol: A randomized double-blind placebo-controlled trial</title><title>Contraception (Stoneham)</title><addtitle>Contraception</addtitle><description>A prospective randomized double-blind placebo-controlled trial was conducted in 70 subjects to determine whether pre-treatment with misoprostol could facilitate termination of second trimester pregnancy by gemeprost. The women received either 400 μg oral misoprostol or placebo tablets 12 hours before the administration of vaginal pessary of gemeprost 1 mg every 3 hours. There were no significant differences in induction-abortion interval and the amount of gemeprost required between the misoprostol and the placebo group. There was no significant difference in the incidence of side effects or analgesic requirement between the two groups. We conclude that oral misoprostol is not useful in facilitating termination of second trimester pregnancy by gemeprost.</description><subject>Abortion, Induced</subject><subject>Administration, Intravaginal</subject><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Alprostadil - administration & dosage</subject><subject>Alprostadil - adverse effects</subject><subject>Alprostadil - analogs & derivatives</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>gemeprost</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Induced abortion. Therapeutic abortion</subject><subject>Medical sciences</subject><subject>Misoprostol - administration & dosage</subject><subject>Misoprostol - adverse effects</subject><subject>oral misoprostol</subject><subject>Placebos</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second</subject><subject>second trimester termination</subject><issn>0010-7824</issn><issn>1879-0518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1rHCEUhqWkJJu0_yAFL0JJL6bRGWfUXBRC6BcEcpNeix_HxOKMG51tSemPr7O77GVBkON5z-t7HoTOKflICR2uCKGk4aJll3L4UAvaN_QVWlHBZUN6Ko7Q6iA5Qael_CSEcNnzY3QsBGH1rNDfB8hjmPQc0oSTxwVsmhyecxihzJDxOsPjpCf7gn-H-Qk_wgjrnMqMdZWNoaRtleI1vsG5vqUx_AGHXdqYCI2JocrWUVswqanWc04xwvYDHd-g117HAm_39xn68eXzw-235u7-6_fbm7vGdmKYG8-NldJaTiwVjkPXG_DUAWs72TMJTnhvTNcTxgZPgUrXOt4zxsC07SC67gy93_nWrM-bupeqwS3EqCdIm6K46CirrKqQ7YS2LlUyeLWuIHR-UZSoBbpaiKqFqJLbgvZqGXu399-YEdxhaE-59i_2fV2sjr5ysqEcZB1ta4DF5tNOBpXFrwBZFRtgsuBCBjsrl8L_c_wDsFOgKA</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Wong, K.S.</creator><creator>Ngai, C.S.W.</creator><creator>Chan, K.S.</creator><creator>Tang, L.C.H.</creator><creator>Ho, P.C.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960701</creationdate><title>Termination of second trimester pregnancy with gemeprost and misoprostol: A randomized double-blind placebo-controlled trial</title><author>Wong, K.S. ; Ngai, C.S.W. ; Chan, K.S. ; Tang, L.C.H. ; Ho, P.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-f7bc99cc70c18d7e35bef1de4239549ed8ffbb350446f1e19d2d75444eb226833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Abortion, Induced</topic><topic>Administration, Intravaginal</topic><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Alprostadil - administration & dosage</topic><topic>Alprostadil - adverse effects</topic><topic>Alprostadil - analogs & derivatives</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>gemeprost</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Induced abortion. Therapeutic abortion</topic><topic>Medical sciences</topic><topic>Misoprostol - administration & dosage</topic><topic>Misoprostol - adverse effects</topic><topic>oral misoprostol</topic><topic>Placebos</topic><topic>Population</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second</topic><topic>second trimester termination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, K.S.</creatorcontrib><creatorcontrib>Ngai, C.S.W.</creatorcontrib><creatorcontrib>Chan, K.S.</creatorcontrib><creatorcontrib>Tang, L.C.H.</creatorcontrib><creatorcontrib>Ho, P.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Contraception (Stoneham)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, K.S.</au><au>Ngai, C.S.W.</au><au>Chan, K.S.</au><au>Tang, L.C.H.</au><au>Ho, P.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Termination of second trimester pregnancy with gemeprost and misoprostol: A randomized double-blind placebo-controlled trial</atitle><jtitle>Contraception (Stoneham)</jtitle><addtitle>Contraception</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>54</volume><issue>1</issue><spage>23</spage><epage>25</epage><pages>23-25</pages><issn>0010-7824</issn><eissn>1879-0518</eissn><coden>CCPTAY</coden><abstract>A prospective randomized double-blind placebo-controlled trial was conducted in 70 subjects to determine whether pre-treatment with misoprostol could facilitate termination of second trimester pregnancy by gemeprost. The women received either 400 μg oral misoprostol or placebo tablets 12 hours before the administration of vaginal pessary of gemeprost 1 mg every 3 hours. There were no significant differences in induction-abortion interval and the amount of gemeprost required between the misoprostol and the placebo group. There was no significant difference in the incidence of side effects or analgesic requirement between the two groups. We conclude that oral misoprostol is not useful in facilitating termination of second trimester pregnancy by gemeprost.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8804804</pmid><doi>10.1016/0010-7824(96)00115-1</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0010-7824 |
| ispartof | Contraception (Stoneham), 1996-07, Vol.54 (1), p.23-25 |
| issn | 0010-7824 1879-0518 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Abortion, Induced Administration, Intravaginal Administration, Oral Adolescent Adult Alprostadil - administration & dosage Alprostadil - adverse effects Alprostadil - analogs & derivatives Biological and medical sciences Birth control Double-Blind Method Female gemeprost Gynecology. Andrology. Obstetrics Humans Induced abortion. Therapeutic abortion Medical sciences Misoprostol - administration & dosage Misoprostol - adverse effects oral misoprostol Placebos Population Pregnancy Pregnancy Trimester, Second second trimester termination |
| title | Termination of second trimester pregnancy with gemeprost and misoprostol: A randomized double-blind placebo-controlled trial |
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