Current generators and properties of late components evoked in rat olfactory cortex
Following main olfactory bulb (MOB) stimulation at frequencies of 0.1–0.3 Hz, in addition to early field potentials, a frequency-sensitive, surface negative late N2 wave (latency range: 63–96 msec) followed occasionally by a late N3 transient, was evoked in the piriform cortex and endopiriform nucle...
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Veröffentlicht in: | Brain research bulletin 1988-04, Vol.20 (4), p.433-446 |
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description | Following main olfactory bulb (MOB) stimulation at frequencies of 0.1–0.3 Hz, in addition to early field potentials, a frequency-sensitive, surface negative late N2 wave (latency range: 63–96 msec) followed occasionally by a late N3 transient, was evoked in the piriform cortex and endopiriform nucleus of the rat. The N2 wave inverted polarity at the Ib-II cortical layer interface (P2 wave) and was associated with late unit discharges 200 to 1200 μm deep to the turnover point. Response probability, peak latency, recovery curve and frequency-sensitivity of the P2 wave were not significantly different in animals under urethane or pentobarbital. Current-source-density (CSD) analysis revealed that the N2 wave generators were localized to the Ib-II layer interface. Since inhibitory activity does not contribute substantially to the second derivative curve [42,49], CSD analysis strengthens the assumption that late components (LCs) are excitatory events (compound EPSPs) presumably generated on the proximal apical dendritic segments of pyramidal cells by association axons. The early “b” wave in a test response was facilitated, rather than occluded, when a LC was present in the conditioning response, or when the priming volley was delivered to the mediodorsal thalamic nucleus. Clustering of unit and field activity in two distinct periods of the evoked response separated by a prolonged interval of cell silence suggests that cortical coding of olfactory cues might be more efficiently achieved by temporal modulation of the neuronal response rather than by spatial distribution of firing patterns. |
doi_str_mv | 10.1016/0361-9230(88)90133-5 |
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Clustering of unit and field activity in two distinct periods of the evoked response separated by a prolonged interval of cell silence suggests that cortical coding of olfactory cues might be more efficiently achieved by temporal modulation of the neuronal response rather than by spatial distribution of firing patterns.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/0361-9230(88)90133-5</identifier><identifier>PMID: 3395860</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Anesthetics ; Animals ; Biological and medical sciences ; Brain - cytology ; Central nervous system ; Cerebral Cortex - physiology ; Current source density ; Electric Stimulation ; Electrophysiology ; Endopiriform nucleus ; Evoked Potentials ; Fundamental and applied biological sciences. Psychology ; Late evoked components ; Odorants ; Olfactory Bulb - physiology ; Olfactory Pathways - physiology ; Palecortex reactivation ; Piriform cortex ; Rat ; Rats ; Rats, Inbred Strains ; Smell ; Thalamic heterosynaptic facilitation ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research bulletin, 1988-04, Vol.20 (4), p.433-446</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-c62589ed76a3cc7f9443bbf7f64d8d51a055c03065307a492fcdd389793005f63</citedby><cites>FETCH-LOGICAL-c483t-c62589ed76a3cc7f9443bbf7f64d8d51a055c03065307a492fcdd389793005f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0361-9230(88)90133-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7023749$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3395860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferreyra-Moyano, H.</creatorcontrib><creatorcontrib>Cinelli, A.R.</creatorcontrib><creatorcontrib>Molina, J.C.</creatorcontrib><creatorcontrib>Barragán, E.</creatorcontrib><title>Current generators and properties of late components evoked in rat olfactory cortex</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>Following main olfactory bulb (MOB) stimulation at frequencies of 0.1–0.3 Hz, in addition to early field potentials, a frequency-sensitive, surface negative late N2 wave (latency range: 63–96 msec) followed occasionally by a late N3 transient, was evoked in the piriform cortex and endopiriform nucleus of the rat. The N2 wave inverted polarity at the Ib-II cortical layer interface (P2 wave) and was associated with late unit discharges 200 to 1200 μm deep to the turnover point. Response probability, peak latency, recovery curve and frequency-sensitivity of the P2 wave were not significantly different in animals under urethane or pentobarbital. Current-source-density (CSD) analysis revealed that the N2 wave generators were localized to the Ib-II layer interface. Since inhibitory activity does not contribute substantially to the second derivative curve [42,49], CSD analysis strengthens the assumption that late components (LCs) are excitatory events (compound EPSPs) presumably generated on the proximal apical dendritic segments of pyramidal cells by association axons. The early “b” wave in a test response was facilitated, rather than occluded, when a LC was present in the conditioning response, or when the priming volley was delivered to the mediodorsal thalamic nucleus. Clustering of unit and field activity in two distinct periods of the evoked response separated by a prolonged interval of cell silence suggests that cortical coding of olfactory cues might be more efficiently achieved by temporal modulation of the neuronal response rather than by spatial distribution of firing patterns.</description><subject>Anesthetics</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - cytology</subject><subject>Central nervous system</subject><subject>Cerebral Cortex - physiology</subject><subject>Current source density</subject><subject>Electric Stimulation</subject><subject>Electrophysiology</subject><subject>Endopiriform nucleus</subject><subject>Evoked Potentials</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Late evoked components</subject><subject>Odorants</subject><subject>Olfactory Bulb - physiology</subject><subject>Olfactory Pathways - physiology</subject><subject>Palecortex reactivation</subject><subject>Piriform cortex</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Smell</subject><subject>Thalamic heterosynaptic facilitation</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo6-zqP1DIQWQ9tCZd-bwsyOAXLHhQzyGTVCTa0xmTnsX992acYY56qkM971vFQ8gzzl5zxtUbBooPdgR2bcwryzjAIB-QFTcahlEL_ZCszshjctnaD8aYMlJdkAsAK41iK_Jlva8V54V-xxmrX0pt1M-R7mrZYV0yNloSnfyCNJTtrsydbRTvyk-MNM-0R2iZkg89ed-RuuDvJ-RR8lPDp6d5Rb69f_d1_XG4_fzh0_rt7RCEgWUIapTGYtTKQwg6WSFgs0k6KRFNlNwzKQMDpiQw7YUdU4gRjNUWGJNJwRV5eeztz_7aY1vcNreA0-RnLPvmtAHOuWH_BbmwILiyHRRHMNTSWsXkdjVvfb13nLmDdHcw6g5GnTHur3Qne-z5qX-_2WI8h06W-_7Fae9b8FOqfg65nTHNRtDicP3miGGXdpexuhYyzgFjrhgWF0v-9x9_AIHHnTc</recordid><startdate>19880401</startdate><enddate>19880401</enddate><creator>Ferreyra-Moyano, H.</creator><creator>Cinelli, A.R.</creator><creator>Molina, J.C.</creator><creator>Barragán, E.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19880401</creationdate><title>Current generators and properties of late components evoked in rat olfactory cortex</title><author>Ferreyra-Moyano, H. ; Cinelli, A.R. ; Molina, J.C. ; Barragán, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-c62589ed76a3cc7f9443bbf7f64d8d51a055c03065307a492fcdd389793005f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Anesthetics</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - cytology</topic><topic>Central nervous system</topic><topic>Cerebral Cortex - physiology</topic><topic>Current source density</topic><topic>Electric Stimulation</topic><topic>Electrophysiology</topic><topic>Endopiriform nucleus</topic><topic>Evoked Potentials</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Late evoked components</topic><topic>Odorants</topic><topic>Olfactory Bulb - physiology</topic><topic>Olfactory Pathways - physiology</topic><topic>Palecortex reactivation</topic><topic>Piriform cortex</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Smell</topic><topic>Thalamic heterosynaptic facilitation</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferreyra-Moyano, H.</creatorcontrib><creatorcontrib>Cinelli, A.R.</creatorcontrib><creatorcontrib>Molina, J.C.</creatorcontrib><creatorcontrib>Barragán, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferreyra-Moyano, H.</au><au>Cinelli, A.R.</au><au>Molina, J.C.</au><au>Barragán, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current generators and properties of late components evoked in rat olfactory cortex</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1988-04-01</date><risdate>1988</risdate><volume>20</volume><issue>4</issue><spage>433</spage><epage>446</epage><pages>433-446</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>Following main olfactory bulb (MOB) stimulation at frequencies of 0.1–0.3 Hz, in addition to early field potentials, a frequency-sensitive, surface negative late N2 wave (latency range: 63–96 msec) followed occasionally by a late N3 transient, was evoked in the piriform cortex and endopiriform nucleus of the rat. The N2 wave inverted polarity at the Ib-II cortical layer interface (P2 wave) and was associated with late unit discharges 200 to 1200 μm deep to the turnover point. Response probability, peak latency, recovery curve and frequency-sensitivity of the P2 wave were not significantly different in animals under urethane or pentobarbital. Current-source-density (CSD) analysis revealed that the N2 wave generators were localized to the Ib-II layer interface. Since inhibitory activity does not contribute substantially to the second derivative curve [42,49], CSD analysis strengthens the assumption that late components (LCs) are excitatory events (compound EPSPs) presumably generated on the proximal apical dendritic segments of pyramidal cells by association axons. The early “b” wave in a test response was facilitated, rather than occluded, when a LC was present in the conditioning response, or when the priming volley was delivered to the mediodorsal thalamic nucleus. 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subjects | Anesthetics Animals Biological and medical sciences Brain - cytology Central nervous system Cerebral Cortex - physiology Current source density Electric Stimulation Electrophysiology Endopiriform nucleus Evoked Potentials Fundamental and applied biological sciences. Psychology Late evoked components Odorants Olfactory Bulb - physiology Olfactory Pathways - physiology Palecortex reactivation Piriform cortex Rat Rats Rats, Inbred Strains Smell Thalamic heterosynaptic facilitation Vertebrates: nervous system and sense organs |
title | Current generators and properties of late components evoked in rat olfactory cortex |
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