Current generators and properties of late components evoked in rat olfactory cortex

Following main olfactory bulb (MOB) stimulation at frequencies of 0.1–0.3 Hz, in addition to early field potentials, a frequency-sensitive, surface negative late N2 wave (latency range: 63–96 msec) followed occasionally by a late N3 transient, was evoked in the piriform cortex and endopiriform nucle...

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Veröffentlicht in:Brain research bulletin 1988-04, Vol.20 (4), p.433-446
Hauptverfasser: Ferreyra-Moyano, H., Cinelli, A.R., Molina, J.C., Barragán, E.
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Cinelli, A.R.
Molina, J.C.
Barragán, E.
description Following main olfactory bulb (MOB) stimulation at frequencies of 0.1–0.3 Hz, in addition to early field potentials, a frequency-sensitive, surface negative late N2 wave (latency range: 63–96 msec) followed occasionally by a late N3 transient, was evoked in the piriform cortex and endopiriform nucleus of the rat. The N2 wave inverted polarity at the Ib-II cortical layer interface (P2 wave) and was associated with late unit discharges 200 to 1200 μm deep to the turnover point. Response probability, peak latency, recovery curve and frequency-sensitivity of the P2 wave were not significantly different in animals under urethane or pentobarbital. Current-source-density (CSD) analysis revealed that the N2 wave generators were localized to the Ib-II layer interface. Since inhibitory activity does not contribute substantially to the second derivative curve [42,49], CSD analysis strengthens the assumption that late components (LCs) are excitatory events (compound EPSPs) presumably generated on the proximal apical dendritic segments of pyramidal cells by association axons. The early “b” wave in a test response was facilitated, rather than occluded, when a LC was present in the conditioning response, or when the priming volley was delivered to the mediodorsal thalamic nucleus. Clustering of unit and field activity in two distinct periods of the evoked response separated by a prolonged interval of cell silence suggests that cortical coding of olfactory cues might be more efficiently achieved by temporal modulation of the neuronal response rather than by spatial distribution of firing patterns.
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source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Anesthetics
Animals
Biological and medical sciences
Brain - cytology
Central nervous system
Cerebral Cortex - physiology
Current source density
Electric Stimulation
Electrophysiology
Endopiriform nucleus
Evoked Potentials
Fundamental and applied biological sciences. Psychology
Late evoked components
Odorants
Olfactory Bulb - physiology
Olfactory Pathways - physiology
Palecortex reactivation
Piriform cortex
Rat
Rats
Rats, Inbred Strains
Smell
Thalamic heterosynaptic facilitation
Vertebrates: nervous system and sense organs
title Current generators and properties of late components evoked in rat olfactory cortex
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