Transmembrane signaling through CD80 (B7-1) induces growth arrest and cell spreading of human B lymphocytes accompanied by protein tyrosine phosphorylation

We addressed the issue of the role for CD80 (B7-1) expressed on human B cells in transmembrane signaling. Cross-linking of CD80 on B lymphoma Raji cells induced tyrosine phosphorylation in 160-, 120-, 55-, 46- and 44-kDa proteins, which was inhibited by genistein. CD80-mediated signaling resulted in...

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Veröffentlicht in:	Immunology letters 1996-04, Vol.50 (1), p.95-98
Hauptverfasser:	Hirokawa, Makoto, Kuroki, Jun, Kitabayashi, Atsushi, Miura, Akira B.
Format:	Artikel
Sprache:	eng
Schlagworte:	B lymphocyte B-Lymphocytes - cytology B-Lymphocytes - drug effects B7-1 Antigen - pharmacology Burkitt Lymphoma CD80 Cell Division - immunology Cell Movement - drug effects Cell Movement - immunology Humans Phosphorylation - drug effects Protein tyrosine phosphorylation Proteins - metabolism Signal Transduction - drug effects Transmembrane signaling Tumor Cells, Cultured Tyrosine - metabolism
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