Transmembrane signaling through CD80 (B7-1) induces growth arrest and cell spreading of human B lymphocytes accompanied by protein tyrosine phosphorylation
We addressed the issue of the role for CD80 (B7-1) expressed on human B cells in transmembrane signaling. Cross-linking of CD80 on B lymphoma Raji cells induced tyrosine phosphorylation in 160-, 120-, 55-, 46- and 44-kDa proteins, which was inhibited by genistein. CD80-mediated signaling resulted in...
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| Veröffentlicht in: | Immunology letters 1996-04, Vol.50 (1), p.95-98 |
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| container_title | Immunology letters |
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| creator | Hirokawa, Makoto Kuroki, Jun Kitabayashi, Atsushi Miura, Akira B. |
| description | We addressed the issue of the role for CD80 (B7-1) expressed on human B cells in transmembrane signaling. Cross-linking of CD80 on B lymphoma Raji cells induced tyrosine phosphorylation in 160-, 120-, 55-, 46- and 44-kDa proteins, which was inhibited by genistein. CD80-mediated signaling resulted in the inhibition of DNA replication of B cells and induced the changes in morphology like macrophages or fibroblasts. This cell spreading was inhibited by the pre-treatment of the cells with genistein. These results suggest that the CD80 antigen is involved in transmembrane outside-in signaling in B cells and its biological effects appear to be mediated by tyrosine kinases. |
| doi_str_mv | 10.1016/0165-2478(96)02526-6 |
| format | Article |
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Cross-linking of CD80 on B lymphoma Raji cells induced tyrosine phosphorylation in 160-, 120-, 55-, 46- and 44-kDa proteins, which was inhibited by genistein. CD80-mediated signaling resulted in the inhibition of DNA replication of B cells and induced the changes in morphology like macrophages or fibroblasts. This cell spreading was inhibited by the pre-treatment of the cells with genistein. These results suggest that the CD80 antigen is involved in transmembrane outside-in signaling in B cells and its biological effects appear to be mediated by tyrosine kinases.</description><subject>B lymphocyte</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - drug effects</subject><subject>B7-1 Antigen - pharmacology</subject><subject>Burkitt Lymphoma</subject><subject>CD80</subject><subject>Cell Division - immunology</subject><subject>Cell Movement - drug effects</subject><subject>Cell Movement - immunology</subject><subject>Humans</subject><subject>Phosphorylation - drug effects</subject><subject>Protein tyrosine phosphorylation</subject><subject>Proteins - metabolism</subject><subject>Signal Transduction - drug effects</subject><subject>Transmembrane signaling</subject><subject>Tumor Cells, Cultured</subject><subject>Tyrosine - metabolism</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAQtRCobAv_ACSfUHsI2LHj2BckupQPqRKXcrYce7IxSuzFTkD5LfxZHO2qRziMxqN5b8ZvHkKvKHlLCRXvSjRVzVt5rcQNqZtaVOIJ2lHZqoo0vH6Kdo-Q5-gy5x-E0IZxdoEuCoY1otmhPw_JhDzB1JUMOPtDMKMPBzwPKS6HAe8_SoKvb9uK3mAf3GIh40OKv-cBm5Qgz9gEhy2MI87HBMZt5NjjYZlMwLd4XKfjEO06F56xNk5HEzw43K34mOIMPuB5TTH7sr0Ac4m0jmb2MbxAz3ozZnh5zlfo-6e7h_2X6v7b56_7D_eV5Q2fK1CthJ6pnruaABFCdaKvt7ekwrW2ZaXT2861qlOMS9ERyYE3NaNSUAbsCr05zS0f-rkUSXryeVNULhKXrFvJiGKq_i-QNoIzJWkB8hPQFmU5Qa-PyU8mrZoSvZmnN2f05oxWpdjM06LQXp_nL90E7pF0dqv035_6UK7xy0PS2XoIFpxPYGftov_3gr_TpKsC</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>Hirokawa, Makoto</creator><creator>Kuroki, Jun</creator><creator>Kitabayashi, Atsushi</creator><creator>Miura, Akira B.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19960401</creationdate><title>Transmembrane signaling through CD80 (B7-1) induces growth arrest and cell spreading of human B lymphocytes accompanied by protein tyrosine phosphorylation</title><author>Hirokawa, Makoto ; Kuroki, Jun ; Kitabayashi, Atsushi ; Miura, Akira B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-e978ef39f4d20e0669b6f2d20e816d7c73f4dfcbd79b93486b084e452318613e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>B lymphocyte</topic><topic>B-Lymphocytes - cytology</topic><topic>B-Lymphocytes - drug effects</topic><topic>B7-1 Antigen - pharmacology</topic><topic>Burkitt Lymphoma</topic><topic>CD80</topic><topic>Cell Division - immunology</topic><topic>Cell Movement - drug effects</topic><topic>Cell Movement - immunology</topic><topic>Humans</topic><topic>Phosphorylation - drug effects</topic><topic>Protein tyrosine phosphorylation</topic><topic>Proteins - metabolism</topic><topic>Signal Transduction - drug effects</topic><topic>Transmembrane signaling</topic><topic>Tumor Cells, Cultured</topic><topic>Tyrosine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirokawa, Makoto</creatorcontrib><creatorcontrib>Kuroki, Jun</creatorcontrib><creatorcontrib>Kitabayashi, Atsushi</creatorcontrib><creatorcontrib>Miura, Akira B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirokawa, Makoto</au><au>Kuroki, Jun</au><au>Kitabayashi, Atsushi</au><au>Miura, Akira B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmembrane signaling through CD80 (B7-1) induces growth arrest and cell spreading of human B lymphocytes accompanied by protein tyrosine phosphorylation</atitle><jtitle>Immunology letters</jtitle><addtitle>Immunol Lett</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>50</volume><issue>1</issue><spage>95</spage><epage>98</epage><pages>95-98</pages><issn>0165-2478</issn><eissn>1879-0542</eissn><abstract>We addressed the issue of the role for CD80 (B7-1) expressed on human B cells in transmembrane signaling. 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| fulltext | fulltext |
| identifier | ISSN: 0165-2478 |
| ispartof | Immunology letters, 1996-04, Vol.50 (1), p.95-98 |
| issn | 0165-2478 1879-0542 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | B lymphocyte B-Lymphocytes - cytology B-Lymphocytes - drug effects B7-1 Antigen - pharmacology Burkitt Lymphoma CD80 Cell Division - immunology Cell Movement - drug effects Cell Movement - immunology Humans Phosphorylation - drug effects Protein tyrosine phosphorylation Proteins - metabolism Signal Transduction - drug effects Transmembrane signaling Tumor Cells, Cultured Tyrosine - metabolism |
| title | Transmembrane signaling through CD80 (B7-1) induces growth arrest and cell spreading of human B lymphocytes accompanied by protein tyrosine phosphorylation |
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