Distribution of protein kinase C immunoreactivity in rat retina
A polyclonal antiserum to protein kinase C has been used to study the distribution of the enzyme antigenic sites in rat retina. The results indicate that the kinase is concentrated in photoreceptor outer segments as well as in the outer and inner plexiform layers. In identified components of retinal...
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| Veröffentlicht in: | The Histochemical journal 1988-02, Vol.20 (2), p.63-68 |
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| container_end_page | 68 |
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| container_start_page | 63 |
| container_title | The Histochemical journal |
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| creator | WOOD, J. G HART, C. E MAZZEI, G. J GIRARD, P. R KUO, J. F |
| description | A polyclonal antiserum to protein kinase C has been used to study the distribution of the enzyme antigenic sites in rat retina. The results indicate that the kinase is concentrated in photoreceptor outer segments as well as in the outer and inner plexiform layers. In identified components of retinal neuronal circuits, the kinase immunoreactivity is present in photoreceptor presynaptic terminals, in bipolar cell dendrites and axons, and probably in bipolar cell presynaptic terminals impinging on retinal ganglion cell dendrites. Thus, protein kinase C is positioned to play a role in specialized compartments of photoreceptor membrane and at both pre- and postsynaptic levels in the function of retinal neuronal circuits. Label in the nucleus is observed in retinal ganglion cells, but not bipolar or horizontal cells and probably not in amacrine cells. A role for protein kinase C in neuronal function at the level of the cell nucleus is therefore not likely to be universal, but to be determined by the particular properties of individual neuronal types. |
| doi_str_mv | 10.1007/BF01746605 |
| format | Article |
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Label in the nucleus is observed in retinal ganglion cells, but not bipolar or horizontal cells and probably not in amacrine cells. A role for protein kinase C in neuronal function at the level of the cell nucleus is therefore not likely to be universal, but to be determined by the particular properties of individual neuronal types.</description><identifier>ISSN: 0018-2214</identifier><identifier>EISSN: 1573-6865</identifier><identifier>DOI: 10.1007/BF01746605</identifier><identifier>PMID: 3391799</identifier><identifier>CODEN: HISJAE</identifier><language>eng</language><publisher>London: Kluwer</publisher><subject>Animals ; Biological and medical sciences ; Collodion ; Electrophoresis, Polyacrylamide Gel ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Immunohistochemistry ; Male ; Neurons - enzymology ; Photoreceptor Cells - enzymology ; Protein Kinase C - analysis ; Protein Kinase C - immunology ; Protein Kinase C - metabolism ; Rats ; Rats, Inbred Strains ; Retina - enzymology ; Rod Cell Outer Segment - enzymology ; Synapses - enzymology ; Vertebrates: nervous system and sense organs</subject><ispartof>The Histochemical journal, 1988-02, Vol.20 (2), p.63-68</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-3a75b33596dd31375f7e4c843d954fe0ae992de8a3dc9ecaab94edf694c0361f3</citedby><cites>FETCH-LOGICAL-c342t-3a75b33596dd31375f7e4c843d954fe0ae992de8a3dc9ecaab94edf694c0361f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7807829$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3391799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WOOD, J. 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Thus, protein kinase C is positioned to play a role in specialized compartments of photoreceptor membrane and at both pre- and postsynaptic levels in the function of retinal neuronal circuits. Label in the nucleus is observed in retinal ganglion cells, but not bipolar or horizontal cells and probably not in amacrine cells. A role for protein kinase C in neuronal function at the level of the cell nucleus is therefore not likely to be universal, but to be determined by the particular properties of individual neuronal types.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Collodion</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Neurons - enzymology</subject><subject>Photoreceptor Cells - enzymology</subject><subject>Protein Kinase C - analysis</subject><subject>Protein Kinase C - immunology</subject><subject>Protein Kinase C - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Retina - enzymology</subject><subject>Rod Cell Outer Segment - enzymology</subject><subject>Synapses - enzymology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0018-2214</issn><issn>1573-6865</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0DtLBDEUBeAgyrquNvbCFGIhjCaTdyW6uios2Gg9ZDI3EJ3HmmSE_feOOKyl1S3Ox-FyEDol-IpgLK_vVphIJgTme2hOuKS5UILvoznGROVFQdghOorxHWOspRQzNKNUE6n1HN3c-5iCr4bk-y7rXbYJfQLfZR--MxGyZebbduj6AMYm_-XTNhvDYFIWII3kGB0400Q4me4Cva0eXpdP-frl8Xl5u84tZUXKqZG8opRrUdeUUMmdBGYVo7XmzAE2oHVRgzK0thqsMZVmUDuhmcVUEEcX6OK3d_zvc4CYytZHC01jOuiHWEpFsVSq-BcSjrnEhRzh5S-0oY8xgCs3wbcmbEuCy59Zy79ZR3w2tQ5VC_WOTjuO-fmUm2hN44LprI87JtX4XKHpNxBMfn4</recordid><startdate>19880201</startdate><enddate>19880201</enddate><creator>WOOD, J. 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Psychology</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Neurons - enzymology</topic><topic>Photoreceptor Cells - enzymology</topic><topic>Protein Kinase C - analysis</topic><topic>Protein Kinase C - immunology</topic><topic>Protein Kinase C - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Retina - enzymology</topic><topic>Rod Cell Outer Segment - enzymology</topic><topic>Synapses - enzymology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WOOD, J. G</creatorcontrib><creatorcontrib>HART, C. E</creatorcontrib><creatorcontrib>MAZZEI, G. J</creatorcontrib><creatorcontrib>GIRARD, P. R</creatorcontrib><creatorcontrib>KUO, J. 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F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of protein kinase C immunoreactivity in rat retina</atitle><jtitle>The Histochemical journal</jtitle><addtitle>Histochem J</addtitle><date>1988-02-01</date><risdate>1988</risdate><volume>20</volume><issue>2</issue><spage>63</spage><epage>68</epage><pages>63-68</pages><issn>0018-2214</issn><eissn>1573-6865</eissn><coden>HISJAE</coden><abstract>A polyclonal antiserum to protein kinase C has been used to study the distribution of the enzyme antigenic sites in rat retina. The results indicate that the kinase is concentrated in photoreceptor outer segments as well as in the outer and inner plexiform layers. In identified components of retinal neuronal circuits, the kinase immunoreactivity is present in photoreceptor presynaptic terminals, in bipolar cell dendrites and axons, and probably in bipolar cell presynaptic terminals impinging on retinal ganglion cell dendrites. Thus, protein kinase C is positioned to play a role in specialized compartments of photoreceptor membrane and at both pre- and postsynaptic levels in the function of retinal neuronal circuits. Label in the nucleus is observed in retinal ganglion cells, but not bipolar or horizontal cells and probably not in amacrine cells. A role for protein kinase C in neuronal function at the level of the cell nucleus is therefore not likely to be universal, but to be determined by the particular properties of individual neuronal types.</abstract><cop>London</cop><pub>Kluwer</pub><pmid>3391799</pmid><doi>10.1007/BF01746605</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Histochemical journal, 1988-02, Vol.20 (2), p.63-68 |
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| language | eng |
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| subjects | Animals Biological and medical sciences Collodion Electrophoresis, Polyacrylamide Gel Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Immunohistochemistry Male Neurons - enzymology Photoreceptor Cells - enzymology Protein Kinase C - analysis Protein Kinase C - immunology Protein Kinase C - metabolism Rats Rats, Inbred Strains Retina - enzymology Rod Cell Outer Segment - enzymology Synapses - enzymology Vertebrates: nervous system and sense organs |
| title | Distribution of protein kinase C immunoreactivity in rat retina |
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