Tumor Necrosis Factor Induces Tissue Factor-Like Activity in Human Leukemia Cell Line U937 and Peripheral Blood Monocytes

The induction of procoagulant activity (PCA) by human recombinant tumor necrosis factor (rTNF) was studied in human monoblastic leukemia cell line U937 and human peripheral blood monocytes. Using a one-step recalcifica-ting clotting assay, PCA in cell lysates or whole cell preparations was measured...

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Veröffentlicht in:	Blood 1988-07, Vol.72 (1), p.128-133
Hauptverfasser:	Conkling, Paul R., Greenberg, Charles S., Weinberg, J.Brice
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Coagulation Factors - biosynthesis Cell Line Hematologic and hematopoietic diseases Humans Interferon-gamma - pharmacology Leukemia, Monocytic, Acute - blood Leukemia, Monocytic, Acute - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Monocytes - metabolism Recombinant Proteins - pharmacology Thromboplastin - biosynthesis Tumor Necrosis Factor-alpha - pharmacology
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