Purification of Bovine Thymus Cytosolic C-Terminal Src Kinase (CSK) and Demonstration of Differential Efficiencies of Phosphorylation and Inactivation of p56lyn and pp60c-src by CSK

The C-terminal src kinase (CSK) is a ubiquitously expressed, cytosolic enzyme capable of phosphorylating and inactivating several plasma membrane-bound src-family protein tyrosine kinases in vitro [Nada, S., Okada, M., MacAuley, A., Cooper, J. A., & Nakagawa, H. (1990) Nature 351, 69−72; Bergman...

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Veröffentlicht in:	Biochemistry (Easton) 1996-09, Vol.35 (36), p.11874-11887
Hauptverfasser:	Cheng, Heung-Chin, Bjorge, Jeffrey D, Aebersold, Ruedi, Fujita, Donald J, Wang, Jerry H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cattle Chromatography Chromatography, High Pressure Liquid Cytosol - enzymology Molecular Sequence Data Peptide Mapping Peptides - metabolism Phosphopeptides - chemistry Phosphorylation Protein-Tyrosine Kinases - isolation & purification Protein-Tyrosine Kinases - metabolism Protein-Tyrosine Kinases - pharmacology Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-fyn Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors Proto-Oncogene Proteins pp60(c-src) - chemistry Proto-Oncogene Proteins pp60(c-src) - metabolism src-Family Kinases - antagonists & inhibitors src-Family Kinases - chemistry src-Family Kinases - metabolism Substrate Specificity Thymus Gland - enzymology Trypsin - metabolism
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