Pharmaokinetics of beta-escin after administration of various Aesculus extract containing formulations
With a specific radioimmunoassay the pharmacokinetics and relative bioavailability of escin was measured after administration of different formulations containing Aesculus-extract. Of special interest was the relative bioavailability of escin after administration of a newly developed film-coated tab...
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| Veröffentlicht in: | Pharmazie 1996-08, Vol.51 (8), p.577-581 |
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| container_end_page | 581 |
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| container_title | Pharmazie |
| container_volume | 51 |
| creator | Oschmann, R Biber, A Lang, F Stumpf, H Kunz, K |
| description | With a specific radioimmunoassay the pharmacokinetics and relative bioavailability of escin was measured after administration of different formulations containing Aesculus-extract. Of special interest was the relative bioavailability of escin after administration of a newly developed film-coated tablet with sustained release in comparison to a reference formulation. In a cross-over steady-state study in 24 volunteers bioequivalence of test and reference preparation could be demonstrated. The 90% confidence interval of the AUC (O-tau) was 98.3 to 120.9%. |
| format | Article |
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Of special interest was the relative bioavailability of escin after administration of a newly developed film-coated tablet with sustained release in comparison to a reference formulation. In a cross-over steady-state study in 24 volunteers bioequivalence of test and reference preparation could be demonstrated. 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| fulltext | fulltext |
| identifier | ISSN: 0031-7144 |
| ispartof | Pharmazie, 1996-08, Vol.51 (8), p.577-581 |
| issn | 0031-7144 |
| language | ger |
| recordid | cdi_proquest_miscellaneous_78306357 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Biological Availability Cross-Over Studies Escin - blood Escin - pharmacokinetics Female Humans Male Middle Aged Plants, Medicinal - chemistry Radioimmunoassay Tablets, Enteric-Coated Therapeutic Equivalency Tissue Extracts - pharmacokinetics |
| title | Pharmaokinetics of beta-escin after administration of various Aesculus extract containing formulations |
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