Acute and chronic effects of ethanol on papillary muscles from spontaneously hypertensive rats
The effects of chronic ethanol ingestion (12 weeks) on the mechanical properties of hypertrophied papillary muscle and the in vitro effects of ethanol (80–640 mg/dl) was studied. Papillary muscles from spontaneously hypertensive rats (SHRs) and their normotensive controls, the Wistar-Kyoto rat (WKY)...
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| Veröffentlicht in: | European journal of pharmacology 1996-04, Vol.302 (1), p.61-67 |
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| container_title | European journal of pharmacology |
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| creator | Brown, Ricardo A. Savage, Adedapo O. Lloyd, Thomas C. |
| description | The effects of chronic ethanol ingestion (12 weeks) on the mechanical properties of hypertrophied papillary muscle and the in vitro effects of ethanol (80–640 mg/dl) was studied. Papillary muscles from spontaneously hypertensive rats (SHRs) and their normotensive controls, the Wistar-Kyoto rat (WKY), were used in this study. Peak- developed tension was significantly less in muscles obtained from SHR compared with WKY even when normalized for muscle cross-sectional area. Chronic ethanol ingestion resulted in a significant shortening of both contraction and relaxation duration in muscles from SHR and WKY. In muscles from SHR and WKY, acute in vitro ethanol exposure produced concentration-dependent negative inotropic effects that were associated with a reduction in the duration of contraction and relaxation and marked slowing in the maximum velocities of tension development and decay. These findings suggest that the contractile response to ethanol exposure, in vitro, is not modified by either chronic ethanol ingestion or hypertension. |
| doi_str_mv | 10.1016/0014-2999(96)00095-7 |
| format | Article |
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Papillary muscles from spontaneously hypertensive rats (SHRs) and their normotensive controls, the Wistar-Kyoto rat (WKY), were used in this study. Peak- developed tension was significantly less in muscles obtained from SHR compared with WKY even when normalized for muscle cross-sectional area. Chronic ethanol ingestion resulted in a significant shortening of both contraction and relaxation duration in muscles from SHR and WKY. In muscles from SHR and WKY, acute in vitro ethanol exposure produced concentration-dependent negative inotropic effects that were associated with a reduction in the duration of contraction and relaxation and marked slowing in the maximum velocities of tension development and decay. 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Papillary muscles from spontaneously hypertensive rats (SHRs) and their normotensive controls, the Wistar-Kyoto rat (WKY), were used in this study. Peak- developed tension was significantly less in muscles obtained from SHR compared with WKY even when normalized for muscle cross-sectional area. Chronic ethanol ingestion resulted in a significant shortening of both contraction and relaxation duration in muscles from SHR and WKY. In muscles from SHR and WKY, acute in vitro ethanol exposure produced concentration-dependent negative inotropic effects that were associated with a reduction in the duration of contraction and relaxation and marked slowing in the maximum velocities of tension development and decay. These findings suggest that the contractile response to ethanol exposure, in vitro, is not modified by either chronic ethanol ingestion or hypertension.</description><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Depression, Chemical</subject><subject>Ethanol - pharmacology</subject><subject>Ethanol, chronic</subject><subject>Hypertension</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardial Contraction - drug effects</subject><subject>Papillary muscle</subject><subject>Papillary Muscles - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Spontaneously hypertensive rat (SHR)</subject><subject>Toxicology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVoSbdp_kEKOpTQHtyOLFuyLoEQ-gWBXtprhSKNWAVbciU7sP8-2uyyx56EeJ8Z3nkIuWLwmQETXwBY17RKqY9KfAIA1TfyjGzYIFUDkrWvyOaEvCFvS3msUK_a_pycVwaU4hvy99auC1ITHbXbnGKwFL1HuxSaPMVla2IaaYp0NnMYR5N3dFqLHbFQn9NEy5ziYiKmtYw7ut3NmBeMJTwhzWYp78hrb8aCl8f3gvz59vX33Y_m_tf3n3e3943lg1hqxXbwSqKQHLyQgwTGkEOPHXfQGmbBSAHWGcS-r-nAmeu6HpwTnItKXZDrw945p38rlkVPoVishV-qaTlw6FTHK9gdQJtTKRm9nnOY6lmagd5r1Xtneu9Mq_2natWyjr0_7l8fJnSnoaPHmn845qZYM_psog3lhHHGmGSiYjcHDKuLp4BZFxswWnQhV-fapfD_Hs-3apPA</recordid><startdate>19960429</startdate><enddate>19960429</enddate><creator>Brown, Ricardo A.</creator><creator>Savage, Adedapo O.</creator><creator>Lloyd, Thomas C.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960429</creationdate><title>Acute and chronic effects of ethanol on papillary muscles from spontaneously hypertensive rats</title><author>Brown, Ricardo A. ; Savage, Adedapo O. ; Lloyd, Thomas C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-2928f97e6730f6787011e305e43d02a1c0a760cdaee55870831d4450dd6336e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Depression, Chemical</topic><topic>Ethanol - pharmacology</topic><topic>Ethanol, chronic</topic><topic>Hypertension</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardial Contraction - drug effects</topic><topic>Papillary muscle</topic><topic>Papillary Muscles - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><topic>Spontaneously hypertensive rat (SHR)</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, Ricardo A.</creatorcontrib><creatorcontrib>Savage, Adedapo O.</creatorcontrib><creatorcontrib>Lloyd, Thomas C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brown, Ricardo A.</au><au>Savage, Adedapo O.</au><au>Lloyd, Thomas C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute and chronic effects of ethanol on papillary muscles from spontaneously hypertensive rats</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1996-04-29</date><risdate>1996</risdate><volume>302</volume><issue>1</issue><spage>61</spage><epage>67</epage><pages>61-67</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The effects of chronic ethanol ingestion (12 weeks) on the mechanical properties of hypertrophied papillary muscle and the in vitro effects of ethanol (80–640 mg/dl) was studied. Papillary muscles from spontaneously hypertensive rats (SHRs) and their normotensive controls, the Wistar-Kyoto rat (WKY), were used in this study. Peak- developed tension was significantly less in muscles obtained from SHR compared with WKY even when normalized for muscle cross-sectional area. Chronic ethanol ingestion resulted in a significant shortening of both contraction and relaxation duration in muscles from SHR and WKY. In muscles from SHR and WKY, acute in vitro ethanol exposure produced concentration-dependent negative inotropic effects that were associated with a reduction in the duration of contraction and relaxation and marked slowing in the maximum velocities of tension development and decay. These findings suggest that the contractile response to ethanol exposure, in vitro, is not modified by either chronic ethanol ingestion or hypertension.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8790993</pmid><doi>10.1016/0014-2999(96)00095-7</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of pharmacology, 1996-04, Vol.302 (1), p.61-67 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Blood Pressure - drug effects Body Weight - drug effects Central Nervous System Depressants - pharmacology Depression, Chemical Ethanol - pharmacology Ethanol, chronic Hypertension In Vitro Techniques Male Medical sciences Myocardial Contraction - drug effects Papillary muscle Papillary Muscles - drug effects Rats Rats, Inbred SHR Rats, Inbred WKY Spontaneously hypertensive rat (SHR) Toxicology |
| title | Acute and chronic effects of ethanol on papillary muscles from spontaneously hypertensive rats |
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