Cyclic AMP-dependent phosphodiesterase isozyme-specific potentiation by protein kinase C in hypertrophic cardiomyopathic hamster hearts

We recently reported that protein kinase C (PKC) potentiates cAMP-dependent phosphodiesterase (PDE) activity in Syrian hamster hearts with hypertrophic cardiomyopathy (HCM) but not in control hamster hearts. In this study, we examined the mechanism of this PKC/PDE interaction by identifying the PDE...

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Veröffentlicht in:	Molecular pharmacology 1996-09, Vol.50 (3), p.549-555
Hauptverfasser:	Yu, H, Cai, J J, Lee, H C
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - isolation & purification 3',5'-Cyclic-AMP Phosphodiesterases - metabolism 3',5'-Cyclic-GMP Phosphodiesterases - metabolism Animals Brain - enzymology Cardiomyopathy, Hypertrophic - enzymology Cardiomyopathy, Hypertrophic - genetics Cells, Cultured Chromatography, High Pressure Liquid Cricetinae Cyclic Nucleotide Phosphodiesterases, Type 1 Heart Ventricles Isoenzymes - isolation & purification Isoenzymes - metabolism Kinetics Mesocricetus Molecular Weight Myocardium - enzymology Phosphorylation Protein Kinase C - metabolism Rats Reference Values
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