Platelet membrane receptor glycoprotein IIb/IIIa antagonism in unstable angina : The Canadian lamifiban study

Ligand binding to the platelet membrane receptor glycoprotein (GP) IIb/IIIa, the final and obligatory step to platelet aggregation, can now be inhibited by pharmacological agents. This study was designed to evaluate the potential of lamifiban, a novel nonpeptide antagonist of GP IIb/IIIa, for the ma...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1996-09, Vol.94 (5), p.899-905
Hauptverfasser:	THEROUX, P, KOUZ, S, DUPUIS, R, KELLS, C, BOKSLAG, M, STEINER, B, RAPOLD, H. J, ROY, L, KNUDTSON, P. L, DIODATI, J. G, MARQUIS, J.-F, NASMITH, J, FUNG, A. Y, BOUDREAULT, J.-R, DELAGE, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - antagonists & inhibitors Acetates - therapeutic use Adult Aged Angina, Unstable - drug therapy Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiovascular system Dose-Response Relationship, Drug Double-Blind Method Female Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - therapeutic use Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Prospective Studies Tyrosine - analogs & derivatives Tyrosine - antagonists & inhibitors Tyrosine - therapeutic use
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