Thallium-201 Scintigraphy to Assess Effect of Chemotherapy in Osteosarcoma
Imaging results in patients with high-grade osteosarcoma of the extremities were reviewed to determine whether scintigraphic appearance correlated with histologic response to preoperative chemotherapy. Histologically, the percent tumor necrosis in specimens from 30 patients were classified into thre...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1996-09, Vol.37 (9), p.1444-1448 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Ohtomo, Katsuyuki Terui, Shoji Yokoyama, Ryohei Abe, Hiroyuki Terauchi, Takashi Maeda, Go Beppu, Yasuo Fukuma, Hisatoshi |
| description | Imaging results in patients with high-grade osteosarcoma of the extremities were reviewed to determine whether scintigraphic appearance correlated with histologic response to preoperative chemotherapy.
Histologically, the percent tumor necrosis in specimens from 30 patients were classified into three grades: grade 1 = necrosis less than 60%, grade 2 = 60%-89% necrosis and grade 3 = diffuse necrosis greater than 90% based upon whole transverse sections. Scintigraphically, we analyzed 201TI uptake before and after preoperative chemotherapy. The changes in the tumor-to-background ratio were defined by an alteration ratio.
Of the 11 patients with a grade 1 response, the ratio showed -67.1% +/- 45.4% (mean +/- s.d.). Of the 9 patients with a grade 2 response, the ratio showed 37.9% +/- 29.9% of the 10 patients with a grade 3 response the ratio showed 105.5% +/- 12.4%. The ratios correlated well with the histologic grades (p < 0.0001; analysis of variance).
Thallium-201 scintigraphy accurately assesses the effect of chemotherapy on osteosarcoma. |
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Histologically, the percent tumor necrosis in specimens from 30 patients were classified into three grades: grade 1 = necrosis less than 60%, grade 2 = 60%-89% necrosis and grade 3 = diffuse necrosis greater than 90% based upon whole transverse sections. Scintigraphically, we analyzed 201TI uptake before and after preoperative chemotherapy. The changes in the tumor-to-background ratio were defined by an alteration ratio.
Of the 11 patients with a grade 1 response, the ratio showed -67.1% +/- 45.4% (mean +/- s.d.). Of the 9 patients with a grade 2 response, the ratio showed 37.9% +/- 29.9% of the 10 patients with a grade 3 response the ratio showed 105.5% +/- 12.4%. The ratios correlated well with the histologic grades (p < 0.0001; analysis of variance).
Thallium-201 scintigraphy accurately assesses the effect of chemotherapy on osteosarcoma.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 8790189</identifier><identifier>CODEN: JNMEAQ</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - drug therapy ; Bone Neoplasms - mortality ; Chemotherapy, Adjuvant ; Child ; Female ; Femoral Neoplasms - diagnostic imaging ; Femoral Neoplasms - drug therapy ; Femoral Neoplasms - mortality ; Humans ; Male ; Osteosarcoma - diagnostic imaging ; Osteosarcoma - drug therapy ; Osteosarcoma - mortality ; Radionuclide Imaging ; Thallium ; Thallium Radioisotopes</subject><ispartof>The Journal of nuclear medicine (1978), 1996-09, Vol.37 (9), p.1444-1448</ispartof><rights>Copyright Society of Nuclear Medicine Sep 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8790189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohtomo, Katsuyuki</creatorcontrib><creatorcontrib>Terui, Shoji</creatorcontrib><creatorcontrib>Yokoyama, Ryohei</creatorcontrib><creatorcontrib>Abe, Hiroyuki</creatorcontrib><creatorcontrib>Terauchi, Takashi</creatorcontrib><creatorcontrib>Maeda, Go</creatorcontrib><creatorcontrib>Beppu, Yasuo</creatorcontrib><creatorcontrib>Fukuma, Hisatoshi</creatorcontrib><title>Thallium-201 Scintigraphy to Assess Effect of Chemotherapy in Osteosarcoma</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>Imaging results in patients with high-grade osteosarcoma of the extremities were reviewed to determine whether scintigraphic appearance correlated with histologic response to preoperative chemotherapy.
Histologically, the percent tumor necrosis in specimens from 30 patients were classified into three grades: grade 1 = necrosis less than 60%, grade 2 = 60%-89% necrosis and grade 3 = diffuse necrosis greater than 90% based upon whole transverse sections. Scintigraphically, we analyzed 201TI uptake before and after preoperative chemotherapy. The changes in the tumor-to-background ratio were defined by an alteration ratio.
Of the 11 patients with a grade 1 response, the ratio showed -67.1% +/- 45.4% (mean +/- s.d.). Of the 9 patients with a grade 2 response, the ratio showed 37.9% +/- 29.9% of the 10 patients with a grade 3 response the ratio showed 105.5% +/- 12.4%. The ratios correlated well with the histologic grades (p < 0.0001; analysis of variance).
Thallium-201 scintigraphy accurately assesses the effect of chemotherapy on osteosarcoma.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - drug therapy</subject><subject>Bone Neoplasms - mortality</subject><subject>Chemotherapy, Adjuvant</subject><subject>Child</subject><subject>Female</subject><subject>Femoral Neoplasms - diagnostic imaging</subject><subject>Femoral Neoplasms - drug therapy</subject><subject>Femoral Neoplasms - mortality</subject><subject>Humans</subject><subject>Male</subject><subject>Osteosarcoma - diagnostic imaging</subject><subject>Osteosarcoma - drug therapy</subject><subject>Osteosarcoma - mortality</subject><subject>Radionuclide Imaging</subject><subject>Thallium</subject><subject>Thallium Radioisotopes</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0DtrwzAUBWBRWtI07U8oiA7tZNBb12MI6YtAhqazUGw5VrCtVLIp-fd1SKZOdzgfh8O9QlMqucykUvoaTQlVNJOSyFt0l9KeEKIAYIImoHNCIZ-iz01tm8YPbcYIxV-F73q_i_ZQH3Ef8DwllxJeVpUrehwqvKhdG_rajeKIfYfXqXch2ViE1t6jm8o2yT1c7gx9vy43i_dstX77WMxXWc2U7DMGSkgLVU5AKs2sc0wKAWBtVXBL7bYEwgFEzlUBgsnRlSWruOBMliczQ8_n3kMMP4NLvWl9KlzT2M6FIRkNLAcNeoRP_-A-DLEbtxlGcyqJlmJEjxc0bFtXmkP0rY1Hc_nQmL-c89rv6l8fnemGonE2nvC-a7k2uaFCCP4HlUlu3A</recordid><startdate>19960901</startdate><enddate>19960901</enddate><creator>Ohtomo, Katsuyuki</creator><creator>Terui, Shoji</creator><creator>Yokoyama, Ryohei</creator><creator>Abe, Hiroyuki</creator><creator>Terauchi, Takashi</creator><creator>Maeda, Go</creator><creator>Beppu, Yasuo</creator><creator>Fukuma, Hisatoshi</creator><general>Soc Nuclear Med</general><general>Society of Nuclear Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>19960901</creationdate><title>Thallium-201 Scintigraphy to Assess Effect of Chemotherapy in Osteosarcoma</title><author>Ohtomo, Katsuyuki ; Terui, Shoji ; Yokoyama, Ryohei ; Abe, Hiroyuki ; Terauchi, Takashi ; Maeda, Go ; Beppu, Yasuo ; Fukuma, Hisatoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h265t-28645a8f9085672aee254488aafc3a1abd803884936c8425908dd2f34325dafc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - drug therapy</topic><topic>Bone Neoplasms - mortality</topic><topic>Chemotherapy, Adjuvant</topic><topic>Child</topic><topic>Female</topic><topic>Femoral Neoplasms - diagnostic imaging</topic><topic>Femoral Neoplasms - drug therapy</topic><topic>Femoral Neoplasms - mortality</topic><topic>Humans</topic><topic>Male</topic><topic>Osteosarcoma - diagnostic imaging</topic><topic>Osteosarcoma - drug therapy</topic><topic>Osteosarcoma - mortality</topic><topic>Radionuclide Imaging</topic><topic>Thallium</topic><topic>Thallium Radioisotopes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohtomo, Katsuyuki</creatorcontrib><creatorcontrib>Terui, Shoji</creatorcontrib><creatorcontrib>Yokoyama, Ryohei</creatorcontrib><creatorcontrib>Abe, Hiroyuki</creatorcontrib><creatorcontrib>Terauchi, Takashi</creatorcontrib><creatorcontrib>Maeda, Go</creatorcontrib><creatorcontrib>Beppu, Yasuo</creatorcontrib><creatorcontrib>Fukuma, Hisatoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>ProQuest Biological Science Journals</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohtomo, Katsuyuki</au><au>Terui, Shoji</au><au>Yokoyama, Ryohei</au><au>Abe, Hiroyuki</au><au>Terauchi, Takashi</au><au>Maeda, Go</au><au>Beppu, Yasuo</au><au>Fukuma, Hisatoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thallium-201 Scintigraphy to Assess Effect of Chemotherapy in Osteosarcoma</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1996-09-01</date><risdate>1996</risdate><volume>37</volume><issue>9</issue><spage>1444</spage><epage>1448</epage><pages>1444-1448</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><coden>JNMEAQ</coden><abstract>Imaging results in patients with high-grade osteosarcoma of the extremities were reviewed to determine whether scintigraphic appearance correlated with histologic response to preoperative chemotherapy.
Histologically, the percent tumor necrosis in specimens from 30 patients were classified into three grades: grade 1 = necrosis less than 60%, grade 2 = 60%-89% necrosis and grade 3 = diffuse necrosis greater than 90% based upon whole transverse sections. Scintigraphically, we analyzed 201TI uptake before and after preoperative chemotherapy. The changes in the tumor-to-background ratio were defined by an alteration ratio.
Of the 11 patients with a grade 1 response, the ratio showed -67.1% +/- 45.4% (mean +/- s.d.). Of the 9 patients with a grade 2 response, the ratio showed 37.9% +/- 29.9% of the 10 patients with a grade 3 response the ratio showed 105.5% +/- 12.4%. The ratios correlated well with the histologic grades (p < 0.0001; analysis of variance).
Thallium-201 scintigraphy accurately assesses the effect of chemotherapy on osteosarcoma.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>8790189</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bone Neoplasms - diagnostic imaging Bone Neoplasms - drug therapy Bone Neoplasms - mortality Chemotherapy, Adjuvant Child Female Femoral Neoplasms - diagnostic imaging Femoral Neoplasms - drug therapy Femoral Neoplasms - mortality Humans Male Osteosarcoma - diagnostic imaging Osteosarcoma - drug therapy Osteosarcoma - mortality Radionuclide Imaging Thallium Thallium Radioisotopes |
| title | Thallium-201 Scintigraphy to Assess Effect of Chemotherapy in Osteosarcoma |
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