Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product

Expression of the interleukin-2 receptor (IL-2R$\alpha $) gene is activated by the transcriptional activator protein, Tax (previously referred to as the tat gene product), encoded by the human T-cell leukemia virus (HTLV-I). Multiple protein binding sites for specific DNA-protein interactions were i...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1988-07, Vol.241 (4861), p.89-92
Hauptverfasser:	Ruben, Steven, Poteat, Harry, Tan, Tse-Hua, Kawakami, Kyoshi, Roeder, Robert, Haseltine, William, Rosen, Craig A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antibodies Base Sequence Binding Sites Biological and medical sciences Cell Line Cell lines Deltaretrovirus - genetics DNA - genetics DNA - metabolism Drug receptors Fundamental and applied biological sciences. Psychology Gels Gene expression Gene Expression Regulation - drug effects Gene Products, tat Genes Genetic aspects Genetic transcription Genetics Hormone receptors HTLV viruses Human T lymphotropic virus 1 Immunoglobulin kappa-Chains - genetics Interleukin-2 Leukemia Medical research Microbiology Mutation Plasmids Promoter Regions, Genetic pX genes Receptors Receptors, Immunologic - genetics Receptors, Interleukin-2 Regulatory Sequences, Nucleic Acid Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains T lymphocytes Transcription (Genetics) Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - pharmacology Virology
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