Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells
Membrane microcarriers were used to determine the ability of regional extracellular matrices to direct neural crest cell differentiation in culture. Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing a...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1988-07, Vol.241 (4861), p.86-89 |
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| creator | Perris, Roberto Von Boxberg, Ysander Löfberg, Jan |
| description | Membrane microcarriers were used to determine the ability of regional extracellular matrices to direct neural crest cell differentiation in culture. Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing and by differentiating into pigment cells. In contrast, matrix material from the presumptive site of dorsal root ganglia stimulated pronounced cell-cell association and neurotypic expression. Cell line segregation during ontogeny of the neural crest that leads to diversification into pigment cells of the skin or into elements of the peripheral nervous system appears to be controlled in part by local cell-matrix interactions. |
| doi_str_mv | 10.1126/science.3388022 |
| format | Article |
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Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing and by differentiating into pigment cells. In contrast, matrix material from the presumptive site of dorsal root ganglia stimulated pronounced cell-cell association and neurotypic expression. Cell line segregation during ontogeny of the neural crest that leads to diversification into pigment cells of the skin or into elements of the peripheral nervous system appears to be controlled in part by local cell-matrix interactions.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3388022</identifier><identifier>PMID: 3388022</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Ambystoma mexicanum ; Ambystoma mexicanum - embryology ; Animals ; Antibodies ; Antigens, Surface - analysis ; Biochemistry ; Biological and medical sciences ; Cell Adhesion ; Cell Adhesion Molecules ; Cell aggregates ; Cell Aggregation ; Cell Differentiation ; Cell lines ; Cell regulation ; Cells, Cultured ; Cellular control mechanisms ; Cellular differentiation ; Cultured cells ; Developmental neurology ; Embryology: invertebrates and vertebrates. Teratology ; Embryos ; Epidermis - physiology ; Epithelial Cells ; Extracellular Matrix - physiology ; Fundamental and applied biological sciences. Psychology ; Ganglia, Spinal - embryology ; Ganglia, Spinal - physiology ; Gels ; Matrix materials ; Melanocytes - cytology ; Nervous system ; Neural crest ; Neural Crest - cytology ; Neurobiology ; Neurons ; Neurons - cytology ; Organogenesis. Fetal development ; Organogenesis. Physiological fonctions ; Phenotype ; Physiological aspects ; Pigments ; Pigments, Biological - metabolism ; Skin</subject><ispartof>Science (American Association for the Advancement of Science), 1988-07, Vol.241 (4861), p.86-89</ispartof><rights>Copyright 1988 The American Association for the Advancement of Science</rights><rights>1988 INIST-CNRS</rights><rights>COPYRIGHT 1988 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1988 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jul 1, 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c794t-bb124b551c5863bf399d1bb1fea725ae08ca6bdd51f28b75a876f549605c99f13</citedby><cites>FETCH-LOGICAL-c794t-bb124b551c5863bf399d1bb1fea725ae08ca6bdd51f28b75a876f549605c99f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1701330$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1701330$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,2885,2886,27929,27930,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7726668$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3388022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perris, Roberto</creatorcontrib><creatorcontrib>Von Boxberg, Ysander</creatorcontrib><creatorcontrib>Löfberg, Jan</creatorcontrib><title>Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Membrane microcarriers were used to determine the ability of regional extracellular matrices to direct neural crest cell differentiation in culture. Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing and by differentiating into pigment cells. In contrast, matrix material from the presumptive site of dorsal root ganglia stimulated pronounced cell-cell association and neurotypic expression. Cell line segregation during ontogeny of the neural crest that leads to diversification into pigment cells of the skin or into elements of the peripheral nervous system appears to be controlled in part by local cell-matrix interactions.</description><subject>Ambystoma mexicanum</subject><subject>Ambystoma mexicanum - embryology</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antigens, Surface - analysis</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion</subject><subject>Cell Adhesion Molecules</subject><subject>Cell aggregates</subject><subject>Cell Aggregation</subject><subject>Cell Differentiation</subject><subject>Cell lines</subject><subject>Cell regulation</subject><subject>Cells, Cultured</subject><subject>Cellular control mechanisms</subject><subject>Cellular differentiation</subject><subject>Cultured cells</subject><subject>Developmental neurology</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryos</subject><subject>Epidermis - physiology</subject><subject>Epithelial Cells</subject><subject>Extracellular Matrix - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia, Spinal - embryology</subject><subject>Ganglia, Spinal - physiology</subject><subject>Gels</subject><subject>Matrix materials</subject><subject>Melanocytes - cytology</subject><subject>Nervous system</subject><subject>Neural crest</subject><subject>Neural Crest - cytology</subject><subject>Neurobiology</subject><subject>Neurons</subject><subject>Neurons - cytology</subject><subject>Organogenesis. Fetal development</subject><subject>Organogenesis. Physiological fonctions</subject><subject>Phenotype</subject><subject>Physiological aspects</subject><subject>Pigments</subject><subject>Pigments, Biological - metabolism</subject><subject>Skin</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN081v0zAUAHALgUYpnLmAFCEEh5HNH7ETH7cyyqSyIgpcI8d9Ka4Su9iJtP73GDXaBqrUygdLfj-_Z9l-CL0k-IwQKs6DNmA1nDFWFJjSR2hEsOSppJg9RiOMmUgLnPOn6FkIa4xjTLITdDLwEVrMnFZNctVWfuus0ckX1XmjISQfoQPfGgvJN1gZZ9PFBrSpI_n6C6zrtpuIjE1uoPcxw8RD6JIJNE14jp7UqgnwYpjH6Menq--Tz-lsPr2eXMxSncusS6uK0KzinGheCFbVTMoliYs1qJxyBbjQSlTLJSc1LaqcqyIXNc-kwFxLWRM2Ru92eTfe_e5j-bI1QccTKAuuD2VeUJkLTg9CxinlTPKDkBKSE8wOQ5LJjEieRfjmP7h2vbfxWmIyFgERIqLTHVqpBkpja9d5pVdgId6ss1CbuHwhOM5EfNcx-rBHx7GE1ug9_P0_PIoObruV6kMorxc3x8r5z2Pl5fRIWUxnD-XpPqld08AKyvhzJvOH-nyntXcheKjLjTet8tuS4PJvZ5RDZ5TDV487Xg8v0VctLO_8ffztEFchtkTtldUm3LE8p0KIIrJXO7YOnfP3VXNMGMPsD1oLGqk</recordid><startdate>19880701</startdate><enddate>19880701</enddate><creator>Perris, Roberto</creator><creator>Von Boxberg, Ysander</creator><creator>Löfberg, Jan</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19880701</creationdate><title>Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells</title><author>Perris, Roberto ; Von Boxberg, Ysander ; Löfberg, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c794t-bb124b551c5863bf399d1bb1fea725ae08ca6bdd51f28b75a876f549605c99f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Ambystoma mexicanum</topic><topic>Ambystoma mexicanum - embryology</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antigens, Surface - analysis</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion</topic><topic>Cell Adhesion Molecules</topic><topic>Cell aggregates</topic><topic>Cell Aggregation</topic><topic>Cell Differentiation</topic><topic>Cell lines</topic><topic>Cell regulation</topic><topic>Cells, Cultured</topic><topic>Cellular control mechanisms</topic><topic>Cellular differentiation</topic><topic>Cultured cells</topic><topic>Developmental neurology</topic><topic>Embryology: invertebrates and vertebrates. 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Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing and by differentiating into pigment cells. In contrast, matrix material from the presumptive site of dorsal root ganglia stimulated pronounced cell-cell association and neurotypic expression. Cell line segregation during ontogeny of the neural crest that leads to diversification into pigment cells of the skin or into elements of the peripheral nervous system appears to be controlled in part by local cell-matrix interactions.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3388022</pmid><doi>10.1126/science.3388022</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1988-07, Vol.241 (4861), p.86-89 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78297652 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Ambystoma mexicanum Ambystoma mexicanum - embryology Animals Antibodies Antigens, Surface - analysis Biochemistry Biological and medical sciences Cell Adhesion Cell Adhesion Molecules Cell aggregates Cell Aggregation Cell Differentiation Cell lines Cell regulation Cells, Cultured Cellular control mechanisms Cellular differentiation Cultured cells Developmental neurology Embryology: invertebrates and vertebrates. Teratology Embryos Epidermis - physiology Epithelial Cells Extracellular Matrix - physiology Fundamental and applied biological sciences. Psychology Ganglia, Spinal - embryology Ganglia, Spinal - physiology Gels Matrix materials Melanocytes - cytology Nervous system Neural crest Neural Crest - cytology Neurobiology Neurons Neurons - cytology Organogenesis. Fetal development Organogenesis. Physiological fonctions Phenotype Physiological aspects Pigments Pigments, Biological - metabolism Skin |
| title | Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells |
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