Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells

Membrane microcarriers were used to determine the ability of regional extracellular matrices to direct neural crest cell differentiation in culture. Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing a...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1988-07, Vol.241 (4861), p.86-89
Hauptverfasser: Perris, Roberto, Von Boxberg, Ysander, Löfberg, Jan
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container_title Science (American Association for the Advancement of Science)
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creator Perris, Roberto
Von Boxberg, Ysander
Löfberg, Jan
description Membrane microcarriers were used to determine the ability of regional extracellular matrices to direct neural crest cell differentiation in culture. Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing and by differentiating into pigment cells. In contrast, matrix material from the presumptive site of dorsal root ganglia stimulated pronounced cell-cell association and neurotypic expression. Cell line segregation during ontogeny of the neural crest that leads to diversification into pigment cells of the skin or into elements of the peripheral nervous system appears to be controlled in part by local cell-matrix interactions.
doi_str_mv 10.1126/science.3388022
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Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing and by differentiating into pigment cells. In contrast, matrix material from the presumptive site of dorsal root ganglia stimulated pronounced cell-cell association and neurotypic expression. Cell line segregation during ontogeny of the neural crest that leads to diversification into pigment cells of the skin or into elements of the peripheral nervous system appears to be controlled in part by local cell-matrix interactions.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3388022</identifier><identifier>PMID: 3388022</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Ambystoma mexicanum ; Ambystoma mexicanum - embryology ; Animals ; Antibodies ; Antigens, Surface - analysis ; Biochemistry ; Biological and medical sciences ; Cell Adhesion ; Cell Adhesion Molecules ; Cell aggregates ; Cell Aggregation ; Cell Differentiation ; Cell lines ; Cell regulation ; Cells, Cultured ; Cellular control mechanisms ; Cellular differentiation ; Cultured cells ; Developmental neurology ; Embryology: invertebrates and vertebrates. Teratology ; Embryos ; Epidermis - physiology ; Epithelial Cells ; Extracellular Matrix - physiology ; Fundamental and applied biological sciences. Psychology ; Ganglia, Spinal - embryology ; Ganglia, Spinal - physiology ; Gels ; Matrix materials ; Melanocytes - cytology ; Nervous system ; Neural crest ; Neural Crest - cytology ; Neurobiology ; Neurons ; Neurons - cytology ; Organogenesis. Fetal development ; Organogenesis. 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Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing and by differentiating into pigment cells. In contrast, matrix material from the presumptive site of dorsal root ganglia stimulated pronounced cell-cell association and neurotypic expression. Cell line segregation during ontogeny of the neural crest that leads to diversification into pigment cells of the skin or into elements of the peripheral nervous system appears to be controlled in part by local cell-matrix interactions.</description><subject>Ambystoma mexicanum</subject><subject>Ambystoma mexicanum - embryology</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antigens, Surface - analysis</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion</subject><subject>Cell Adhesion Molecules</subject><subject>Cell aggregates</subject><subject>Cell Aggregation</subject><subject>Cell Differentiation</subject><subject>Cell lines</subject><subject>Cell regulation</subject><subject>Cells, Cultured</subject><subject>Cellular control mechanisms</subject><subject>Cellular differentiation</subject><subject>Cultured cells</subject><subject>Developmental neurology</subject><subject>Embryology: invertebrates and vertebrates. 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Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing and by differentiating into pigment cells. In contrast, matrix material from the presumptive site of dorsal root ganglia stimulated pronounced cell-cell association and neurotypic expression. Cell line segregation during ontogeny of the neural crest that leads to diversification into pigment cells of the skin or into elements of the peripheral nervous system appears to be controlled in part by local cell-matrix interactions.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3388022</pmid><doi>10.1126/science.3388022</doi><tpages>4</tpages></addata></record>
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subjects Ambystoma mexicanum
Ambystoma mexicanum - embryology
Animals
Antibodies
Antigens, Surface - analysis
Biochemistry
Biological and medical sciences
Cell Adhesion
Cell Adhesion Molecules
Cell aggregates
Cell Aggregation
Cell Differentiation
Cell lines
Cell regulation
Cells, Cultured
Cellular control mechanisms
Cellular differentiation
Cultured cells
Developmental neurology
Embryology: invertebrates and vertebrates. Teratology
Embryos
Epidermis - physiology
Epithelial Cells
Extracellular Matrix - physiology
Fundamental and applied biological sciences. Psychology
Ganglia, Spinal - embryology
Ganglia, Spinal - physiology
Gels
Matrix materials
Melanocytes - cytology
Nervous system
Neural crest
Neural Crest - cytology
Neurobiology
Neurons
Neurons - cytology
Organogenesis. Fetal development
Organogenesis. Physiological fonctions
Phenotype
Physiological aspects
Pigments
Pigments, Biological - metabolism
Skin
title Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells
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