Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells

Membrane microcarriers were used to determine the ability of regional extracellular matrices to direct neural crest cell differentiation in culture. Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 1988-07, Vol.241 (4861), p.86-89
Hauptverfasser: Perris, Roberto, Von Boxberg, Ysander, Löfberg, Jan
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 89
container_issue 4861
container_start_page 86
container_title Science (American Association for the Advancement of Science)
container_volume 241
creator Perris, Roberto
Von Boxberg, Ysander
Löfberg, Jan
description Membrane microcarriers were used to determine the ability of regional extracellular matrices to direct neural crest cell differentiation in culture. Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing and by differentiating into pigment cells. In contrast, matrix material from the presumptive site of dorsal root ganglia stimulated pronounced cell-cell association and neurotypic expression. Cell line segregation during ontogeny of the neural crest that leads to diversification into pigment cells of the skin or into elements of the peripheral nervous system appears to be controlled in part by local cell-matrix interactions.
doi_str_mv 10.1126/science.3388022
format Article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_78297652</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A6504620</galeid><jstor_id>1701330</jstor_id><sourcerecordid>A6504620</sourcerecordid><originalsourceid>FETCH-LOGICAL-c794t-bb124b551c5863bf399d1bb1fea725ae08ca6bdd51f28b75a876f549605c99f13</originalsourceid><addsrcrecordid>eNqN081v0zAUAHALgUYpnLmAFCEEh5HNH7ETH7cyyqSyIgpcI8d9Ka4Su9iJtP73GDXaBqrUygdLfj-_Z9l-CL0k-IwQKs6DNmA1nDFWFJjSR2hEsOSppJg9RiOMmUgLnPOn6FkIa4xjTLITdDLwEVrMnFZNctVWfuus0ckX1XmjISQfoQPfGgvJN1gZZ9PFBrSpI_n6C6zrtpuIjE1uoPcxw8RD6JIJNE14jp7UqgnwYpjH6Menq--Tz-lsPr2eXMxSncusS6uK0KzinGheCFbVTMoliYs1qJxyBbjQSlTLJSc1LaqcqyIXNc-kwFxLWRM2Ru92eTfe_e5j-bI1QccTKAuuD2VeUJkLTg9CxinlTPKDkBKSE8wOQ5LJjEieRfjmP7h2vbfxWmIyFgERIqLTHVqpBkpja9d5pVdgId6ss1CbuHwhOM5EfNcx-rBHx7GE1ug9_P0_PIoObruV6kMorxc3x8r5z2Pl5fRIWUxnD-XpPqld08AKyvhzJvOH-nyntXcheKjLjTet8tuS4PJvZ5RDZ5TDV487Xg8v0VctLO_8ffztEFchtkTtldUm3LE8p0KIIrJXO7YOnfP3VXNMGMPsD1oLGqk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213543166</pqid></control><display><type>article</type><title>Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells</title><source>MEDLINE</source><source>Science Magazine</source><source>JSTOR Archive Collection A-Z Listing</source><creator>Perris, Roberto ; Von Boxberg, Ysander ; Löfberg, Jan</creator><creatorcontrib>Perris, Roberto ; Von Boxberg, Ysander ; Löfberg, Jan</creatorcontrib><description>Membrane microcarriers were used to determine the ability of regional extracellular matrices to direct neural crest cell differentiation in culture. Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing and by differentiating into pigment cells. In contrast, matrix material from the presumptive site of dorsal root ganglia stimulated pronounced cell-cell association and neurotypic expression. Cell line segregation during ontogeny of the neural crest that leads to diversification into pigment cells of the skin or into elements of the peripheral nervous system appears to be controlled in part by local cell-matrix interactions.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3388022</identifier><identifier>PMID: 3388022</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Ambystoma mexicanum ; Ambystoma mexicanum - embryology ; Animals ; Antibodies ; Antigens, Surface - analysis ; Biochemistry ; Biological and medical sciences ; Cell Adhesion ; Cell Adhesion Molecules ; Cell aggregates ; Cell Aggregation ; Cell Differentiation ; Cell lines ; Cell regulation ; Cells, Cultured ; Cellular control mechanisms ; Cellular differentiation ; Cultured cells ; Developmental neurology ; Embryology: invertebrates and vertebrates. Teratology ; Embryos ; Epidermis - physiology ; Epithelial Cells ; Extracellular Matrix - physiology ; Fundamental and applied biological sciences. Psychology ; Ganglia, Spinal - embryology ; Ganglia, Spinal - physiology ; Gels ; Matrix materials ; Melanocytes - cytology ; Nervous system ; Neural crest ; Neural Crest - cytology ; Neurobiology ; Neurons ; Neurons - cytology ; Organogenesis. Fetal development ; Organogenesis. Physiological fonctions ; Phenotype ; Physiological aspects ; Pigments ; Pigments, Biological - metabolism ; Skin</subject><ispartof>Science (American Association for the Advancement of Science), 1988-07, Vol.241 (4861), p.86-89</ispartof><rights>Copyright 1988 The American Association for the Advancement of Science</rights><rights>1988 INIST-CNRS</rights><rights>COPYRIGHT 1988 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1988 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jul 1, 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c794t-bb124b551c5863bf399d1bb1fea725ae08ca6bdd51f28b75a876f549605c99f13</citedby><cites>FETCH-LOGICAL-c794t-bb124b551c5863bf399d1bb1fea725ae08ca6bdd51f28b75a876f549605c99f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1701330$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1701330$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,782,786,805,2886,2887,27931,27932,58024,58257</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=7726668$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3388022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perris, Roberto</creatorcontrib><creatorcontrib>Von Boxberg, Ysander</creatorcontrib><creatorcontrib>Löfberg, Jan</creatorcontrib><title>Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Membrane microcarriers were used to determine the ability of regional extracellular matrices to direct neural crest cell differentiation in culture. Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing and by differentiating into pigment cells. In contrast, matrix material from the presumptive site of dorsal root ganglia stimulated pronounced cell-cell association and neurotypic expression. Cell line segregation during ontogeny of the neural crest that leads to diversification into pigment cells of the skin or into elements of the peripheral nervous system appears to be controlled in part by local cell-matrix interactions.</description><subject>Ambystoma mexicanum</subject><subject>Ambystoma mexicanum - embryology</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antigens, Surface - analysis</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion</subject><subject>Cell Adhesion Molecules</subject><subject>Cell aggregates</subject><subject>Cell Aggregation</subject><subject>Cell Differentiation</subject><subject>Cell lines</subject><subject>Cell regulation</subject><subject>Cells, Cultured</subject><subject>Cellular control mechanisms</subject><subject>Cellular differentiation</subject><subject>Cultured cells</subject><subject>Developmental neurology</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryos</subject><subject>Epidermis - physiology</subject><subject>Epithelial Cells</subject><subject>Extracellular Matrix - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia, Spinal - embryology</subject><subject>Ganglia, Spinal - physiology</subject><subject>Gels</subject><subject>Matrix materials</subject><subject>Melanocytes - cytology</subject><subject>Nervous system</subject><subject>Neural crest</subject><subject>Neural Crest - cytology</subject><subject>Neurobiology</subject><subject>Neurons</subject><subject>Neurons - cytology</subject><subject>Organogenesis. Fetal development</subject><subject>Organogenesis. Physiological fonctions</subject><subject>Phenotype</subject><subject>Physiological aspects</subject><subject>Pigments</subject><subject>Pigments, Biological - metabolism</subject><subject>Skin</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN081v0zAUAHALgUYpnLmAFCEEh5HNH7ETH7cyyqSyIgpcI8d9Ka4Su9iJtP73GDXaBqrUygdLfj-_Z9l-CL0k-IwQKs6DNmA1nDFWFJjSR2hEsOSppJg9RiOMmUgLnPOn6FkIa4xjTLITdDLwEVrMnFZNctVWfuus0ckX1XmjISQfoQPfGgvJN1gZZ9PFBrSpI_n6C6zrtpuIjE1uoPcxw8RD6JIJNE14jp7UqgnwYpjH6Menq--Tz-lsPr2eXMxSncusS6uK0KzinGheCFbVTMoliYs1qJxyBbjQSlTLJSc1LaqcqyIXNc-kwFxLWRM2Ru92eTfe_e5j-bI1QccTKAuuD2VeUJkLTg9CxinlTPKDkBKSE8wOQ5LJjEieRfjmP7h2vbfxWmIyFgERIqLTHVqpBkpja9d5pVdgId6ss1CbuHwhOM5EfNcx-rBHx7GE1ug9_P0_PIoObruV6kMorxc3x8r5z2Pl5fRIWUxnD-XpPqld08AKyvhzJvOH-nyntXcheKjLjTet8tuS4PJvZ5RDZ5TDV487Xg8v0VctLO_8ffztEFchtkTtldUm3LE8p0KIIrJXO7YOnfP3VXNMGMPsD1oLGqk</recordid><startdate>19880701</startdate><enddate>19880701</enddate><creator>Perris, Roberto</creator><creator>Von Boxberg, Ysander</creator><creator>Löfberg, Jan</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19880701</creationdate><title>Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells</title><author>Perris, Roberto ; Von Boxberg, Ysander ; Löfberg, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c794t-bb124b551c5863bf399d1bb1fea725ae08ca6bdd51f28b75a876f549605c99f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Ambystoma mexicanum</topic><topic>Ambystoma mexicanum - embryology</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antigens, Surface - analysis</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion</topic><topic>Cell Adhesion Molecules</topic><topic>Cell aggregates</topic><topic>Cell Aggregation</topic><topic>Cell Differentiation</topic><topic>Cell lines</topic><topic>Cell regulation</topic><topic>Cells, Cultured</topic><topic>Cellular control mechanisms</topic><topic>Cellular differentiation</topic><topic>Cultured cells</topic><topic>Developmental neurology</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryos</topic><topic>Epidermis - physiology</topic><topic>Epithelial Cells</topic><topic>Extracellular Matrix - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia, Spinal - embryology</topic><topic>Ganglia, Spinal - physiology</topic><topic>Gels</topic><topic>Matrix materials</topic><topic>Melanocytes - cytology</topic><topic>Nervous system</topic><topic>Neural crest</topic><topic>Neural Crest - cytology</topic><topic>Neurobiology</topic><topic>Neurons</topic><topic>Neurons - cytology</topic><topic>Organogenesis. Fetal development</topic><topic>Organogenesis. Physiological fonctions</topic><topic>Phenotype</topic><topic>Physiological aspects</topic><topic>Pigments</topic><topic>Pigments, Biological - metabolism</topic><topic>Skin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perris, Roberto</creatorcontrib><creatorcontrib>Von Boxberg, Ysander</creatorcontrib><creatorcontrib>Löfberg, Jan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric &amp; Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology &amp; Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts – Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Agricultural Science Database</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric &amp; Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perris, Roberto</au><au>Von Boxberg, Ysander</au><au>Löfberg, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1988-07-01</date><risdate>1988</risdate><volume>241</volume><issue>4861</issue><spage>86</spage><epage>89</epage><pages>86-89</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Membrane microcarriers were used to determine the ability of regional extracellular matrices to direct neural crest cell differentiation in culture. Neural crest cells from the axolotl embryo responded to extracellular matrix material explanted from the subepidermal migratory pathway by dispersing and by differentiating into pigment cells. In contrast, matrix material from the presumptive site of dorsal root ganglia stimulated pronounced cell-cell association and neurotypic expression. Cell line segregation during ontogeny of the neural crest that leads to diversification into pigment cells of the skin or into elements of the peripheral nervous system appears to be controlled in part by local cell-matrix interactions.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3388022</pmid><doi>10.1126/science.3388022</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 1988-07, Vol.241 (4861), p.86-89
issn 0036-8075
1095-9203
language eng
recordid cdi_proquest_miscellaneous_78297652
source MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing
subjects Ambystoma mexicanum
Ambystoma mexicanum - embryology
Animals
Antibodies
Antigens, Surface - analysis
Biochemistry
Biological and medical sciences
Cell Adhesion
Cell Adhesion Molecules
Cell aggregates
Cell Aggregation
Cell Differentiation
Cell lines
Cell regulation
Cells, Cultured
Cellular control mechanisms
Cellular differentiation
Cultured cells
Developmental neurology
Embryology: invertebrates and vertebrates. Teratology
Embryos
Epidermis - physiology
Epithelial Cells
Extracellular Matrix - physiology
Fundamental and applied biological sciences. Psychology
Ganglia, Spinal - embryology
Ganglia, Spinal - physiology
Gels
Matrix materials
Melanocytes - cytology
Nervous system
Neural crest
Neural Crest - cytology
Neurobiology
Neurons
Neurons - cytology
Organogenesis. Fetal development
Organogenesis. Physiological fonctions
Phenotype
Physiological aspects
Pigments
Pigments, Biological - metabolism
Skin
title Local Embryonic Matrices Determine Region-Specific Phenotypes in Neural Crest Cells
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T23%3A34%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Local%20Embryonic%20Matrices%20Determine%20Region-Specific%20Phenotypes%20in%20Neural%20Crest%20Cells&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Perris,%20Roberto&rft.date=1988-07-01&rft.volume=241&rft.issue=4861&rft.spage=86&rft.epage=89&rft.pages=86-89&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.3388022&rft_dat=%3Cgale_proqu%3EA6504620%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213543166&rft_id=info:pmid/3388022&rft_galeid=A6504620&rft_jstor_id=1701330&rfr_iscdi=true