Lack of TGF-alpha and TGF-beta 1 synthesis by human eosinophils in chronic oral ulcers
We recently demonstrated that eosinophils infiltrate prominently into cutaneous wounds in the Syrian hamster and represent a source of transforming growth factor-alpha and transforming growth factor-beta. In this study, we assessed the role of the eosinophil and eosinophil-derived transforming growt...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 1996-06, Vol.81 (6), p.672-681 |
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| container_title | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics |
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| creator | Elovic, A E Gallagher, G T Kabani, S Galli, S J Weller, P F Wong, D T |
| description | We recently demonstrated that eosinophils infiltrate prominently into cutaneous wounds in the Syrian hamster and represent a source of transforming growth factor-alpha and transforming growth factor-beta. In this study, we assessed the role of the eosinophil and eosinophil-derived transforming growth factors in human oral ulcers that exhibit delayed healing, descriptively termed traumatic ulcerative granuloma with stromal eosinophilia. Our aim was to determine whether eosinophils, which characteristically infiltrate traumatic ulcerative granuloma with stromal eosinophilia lesions, produced transforming growth factor-alpha or transforming growth factor-beta. Twelve cases of traumatic ulcerative granuloma with stromal eosinophilia were examined for transforming growth factor-alpha and transforming growth factor-beta mRNA and cellular protein by in situ hybridization and immunohistochemistry. Eosinophils in 92% of the cases did not express detectable cellular levels of mRNA for either of the transforming growth factors. In addition, only a small percentage of the many eosinophils infiltrating these lesions produced transforming growth factor-alpha or transforming growth factor-beta. The lack of significant synthesis of transforming growth factors by eosinophils in most of the cases of traumatic ulcerative granuloma with stromal eosinophilia is in striking contrast to the expression of transforming growth factors by the eosinophils that infiltrate the animal wound-healing model. Our findings may help to explain the delayed healing that is typical of TUGSE lesions. |
| doi_str_mv | 10.1016/S1079-2104(96)80073-4 |
| format | Article |
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In this study, we assessed the role of the eosinophil and eosinophil-derived transforming growth factors in human oral ulcers that exhibit delayed healing, descriptively termed traumatic ulcerative granuloma with stromal eosinophilia. Our aim was to determine whether eosinophils, which characteristically infiltrate traumatic ulcerative granuloma with stromal eosinophilia lesions, produced transforming growth factor-alpha or transforming growth factor-beta. Twelve cases of traumatic ulcerative granuloma with stromal eosinophilia were examined for transforming growth factor-alpha and transforming growth factor-beta mRNA and cellular protein by in situ hybridization and immunohistochemistry. Eosinophils in 92% of the cases did not express detectable cellular levels of mRNA for either of the transforming growth factors. In addition, only a small percentage of the many eosinophils infiltrating these lesions produced transforming growth factor-alpha or transforming growth factor-beta. The lack of significant synthesis of transforming growth factors by eosinophils in most of the cases of traumatic ulcerative granuloma with stromal eosinophilia is in striking contrast to the expression of transforming growth factors by the eosinophils that infiltrate the animal wound-healing model. Our findings may help to explain the delayed healing that is typical of TUGSE lesions.</description><identifier>ISSN: 1079-2104</identifier><identifier>DOI: 10.1016/S1079-2104(96)80073-4</identifier><identifier>PMID: 8784899</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Animals ; Chronic Disease ; Cricetinae ; Dentistry ; Eosinophils - immunology ; Eosinophils - metabolism ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Oral Ulcer - immunology ; Oral Ulcer - metabolism ; Oral Ulcer - pathology ; Oral Ulcer - physiopathology ; RNA, Messenger - analysis ; Transforming Growth Factor alpha - biosynthesis ; Transforming Growth Factor beta - biosynthesis ; Wound Healing - physiology</subject><ispartof>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 1996-06, Vol.81 (6), p.672-681</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8784899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elovic, A E</creatorcontrib><creatorcontrib>Gallagher, G T</creatorcontrib><creatorcontrib>Kabani, S</creatorcontrib><creatorcontrib>Galli, S J</creatorcontrib><creatorcontrib>Weller, P F</creatorcontrib><creatorcontrib>Wong, D T</creatorcontrib><title>Lack of TGF-alpha and TGF-beta 1 synthesis by human eosinophils in chronic oral ulcers</title><title>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</title><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><description>We recently demonstrated that eosinophils infiltrate prominently into cutaneous wounds in the Syrian hamster and represent a source of transforming growth factor-alpha and transforming growth factor-beta. In this study, we assessed the role of the eosinophil and eosinophil-derived transforming growth factors in human oral ulcers that exhibit delayed healing, descriptively termed traumatic ulcerative granuloma with stromal eosinophilia. Our aim was to determine whether eosinophils, which characteristically infiltrate traumatic ulcerative granuloma with stromal eosinophilia lesions, produced transforming growth factor-alpha or transforming growth factor-beta. Twelve cases of traumatic ulcerative granuloma with stromal eosinophilia were examined for transforming growth factor-alpha and transforming growth factor-beta mRNA and cellular protein by in situ hybridization and immunohistochemistry. Eosinophils in 92% of the cases did not express detectable cellular levels of mRNA for either of the transforming growth factors. In addition, only a small percentage of the many eosinophils infiltrating these lesions produced transforming growth factor-alpha or transforming growth factor-beta. The lack of significant synthesis of transforming growth factors by eosinophils in most of the cases of traumatic ulcerative granuloma with stromal eosinophilia is in striking contrast to the expression of transforming growth factors by the eosinophils that infiltrate the animal wound-healing model. Our findings may help to explain the delayed healing that is typical of TUGSE lesions.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Animals</subject><subject>Chronic Disease</subject><subject>Cricetinae</subject><subject>Dentistry</subject><subject>Eosinophils - immunology</subject><subject>Eosinophils - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oral Ulcer - immunology</subject><subject>Oral Ulcer - metabolism</subject><subject>Oral Ulcer - pathology</subject><subject>Oral Ulcer - physiopathology</subject><subject>RNA, Messenger - analysis</subject><subject>Transforming Growth Factor alpha - biosynthesis</subject><subject>Transforming Growth Factor beta - biosynthesis</subject><subject>Wound Healing - physiology</subject><issn>1079-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9ULtOwzAA9AAqpfAJlTwhGAJ27MT2iCpakCoxUFgjxw_F4NghTob8fQNU6IbTnU6n0wGwxugeI1w-vGHERJZjRG9FeccRYiSjZ2D5b1-Ay5Q-EUIlEWIBFpxxyoVYgo-9VF8wWnjYbTPpu0ZCGfSvqs0gIYZpCkNjkkuwnmAztjJAE5MLsWucT9AFqJo-Bqdg7KWHo1emT1fg3EqfzPWJV-B9-3TYPGf7193L5nGfdZjwIcNlIXSuuMXUFCKnopCF1QgTzX88xiylJcstK828PK_5DEJEzZUyWheWrMDNX2_Xx-_RpKFqXVLGexlMHFPFeC4YxXgOrk_BsW6NrrretbKfqtMR5AhLrF2R</recordid><startdate>199606</startdate><enddate>199606</enddate><creator>Elovic, A E</creator><creator>Gallagher, G T</creator><creator>Kabani, S</creator><creator>Galli, S J</creator><creator>Weller, P F</creator><creator>Wong, D T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199606</creationdate><title>Lack of TGF-alpha and TGF-beta 1 synthesis by human eosinophils in chronic oral ulcers</title><author>Elovic, A E ; Gallagher, G T ; Kabani, S ; Galli, S J ; Weller, P F ; Wong, D T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p138t-1659d2c8f14e592495a5fd013d88f1477f44672f76e0632b8b8b339b8ccedd5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Animals</topic><topic>Chronic Disease</topic><topic>Cricetinae</topic><topic>Dentistry</topic><topic>Eosinophils - immunology</topic><topic>Eosinophils - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oral Ulcer - immunology</topic><topic>Oral Ulcer - metabolism</topic><topic>Oral Ulcer - pathology</topic><topic>Oral Ulcer - physiopathology</topic><topic>RNA, Messenger - analysis</topic><topic>Transforming Growth Factor alpha - biosynthesis</topic><topic>Transforming Growth Factor beta - biosynthesis</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elovic, A E</creatorcontrib><creatorcontrib>Gallagher, G T</creatorcontrib><creatorcontrib>Kabani, S</creatorcontrib><creatorcontrib>Galli, S J</creatorcontrib><creatorcontrib>Weller, P F</creatorcontrib><creatorcontrib>Wong, D T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elovic, A E</au><au>Gallagher, G T</au><au>Kabani, S</au><au>Galli, S J</au><au>Weller, P F</au><au>Wong, D T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of TGF-alpha and TGF-beta 1 synthesis by human eosinophils in chronic oral ulcers</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>1996-06</date><risdate>1996</risdate><volume>81</volume><issue>6</issue><spage>672</spage><epage>681</epage><pages>672-681</pages><issn>1079-2104</issn><abstract>We recently demonstrated that eosinophils infiltrate prominently into cutaneous wounds in the Syrian hamster and represent a source of transforming growth factor-alpha and transforming growth factor-beta. In this study, we assessed the role of the eosinophil and eosinophil-derived transforming growth factors in human oral ulcers that exhibit delayed healing, descriptively termed traumatic ulcerative granuloma with stromal eosinophilia. Our aim was to determine whether eosinophils, which characteristically infiltrate traumatic ulcerative granuloma with stromal eosinophilia lesions, produced transforming growth factor-alpha or transforming growth factor-beta. Twelve cases of traumatic ulcerative granuloma with stromal eosinophilia were examined for transforming growth factor-alpha and transforming growth factor-beta mRNA and cellular protein by in situ hybridization and immunohistochemistry. Eosinophils in 92% of the cases did not express detectable cellular levels of mRNA for either of the transforming growth factors. In addition, only a small percentage of the many eosinophils infiltrating these lesions produced transforming growth factor-alpha or transforming growth factor-beta. The lack of significant synthesis of transforming growth factors by eosinophils in most of the cases of traumatic ulcerative granuloma with stromal eosinophilia is in striking contrast to the expression of transforming growth factors by the eosinophils that infiltrate the animal wound-healing model. Our findings may help to explain the delayed healing that is typical of TUGSE lesions.</abstract><cop>United States</cop><pmid>8784899</pmid><doi>10.1016/S1079-2104(96)80073-4</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 1079-2104 |
| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 1996-06, Vol.81 (6), p.672-681 |
| issn | 1079-2104 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Aged Aged, 80 and over Animals Chronic Disease Cricetinae Dentistry Eosinophils - immunology Eosinophils - metabolism Female Humans Immunohistochemistry Male Middle Aged Oral Ulcer - immunology Oral Ulcer - metabolism Oral Ulcer - pathology Oral Ulcer - physiopathology RNA, Messenger - analysis Transforming Growth Factor alpha - biosynthesis Transforming Growth Factor beta - biosynthesis Wound Healing - physiology |
| title | Lack of TGF-alpha and TGF-beta 1 synthesis by human eosinophils in chronic oral ulcers |
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