The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein

The recurrent translocation t(8;16)(p11 ;p13) is a cytogenetic hallmark for the M4/M5 subtype of acute myeloid leukaemia. Here we identify the breakpoint-associated genes. Positional cloning on chromosome 16 implicates the CREB-binding protein (CBP), a transcriptional adaptor/coactivator protein. At...

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Veröffentlicht in:	Nature genetics 1996-09, Vol.14 (1), p.33-41
Hauptverfasser:	Borrow, Julian, Stanton, Vincent P., Andresen, J. Michael, Becher, Reinhard, Behm, Frederick G., Chaganti, Raju S. K., Civin, Curt I., Disteche, Christine, Dubé, Ian, Frischauf, Anna Marie, Horsman, Doug, Mitelman, Felix, Volinia, Stefano, Watmore, Ann E., Housman, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - genetics Agriculture Amino Acid Sequence Animal Genetics and Genomics Animals Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Chromosome Mapping Chromosomes, Human, Pair 16 Chromosomes, Human, Pair 8 Cloning, Molecular CREB-Binding Protein Cricetinae Gene Expression Gene Function Hematologic and hematopoietic diseases Histone Acetyltransferases Human Genetics Humans Leukemia, Monocytic, Acute - genetics Leukemia, Myelomonocytic, Acute - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Molecular Sequence Data Nuclear Proteins - genetics Polymerase Chain Reaction Sequence Homology, Amino Acid Trans-Activators Transcription Factors - genetics Translocation, Genetic Zinc Fingers - genetics
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