Immunosuppressive effect of tacrolimus (FK-506): Bone xenografts in rabbits

We examined the immunomodulatory effect of the macrolide antibiotic FK-506 (tacrolimus) in bone xenograft transplantation. Full-thickness pieces of iliac bone from mongrel dogs were transplanted into the iliac bone of Japanese white rabbits. FK-506 at a dose of 1.6 mg/kg/day was injected into the ra...

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Veröffentlicht in:	Acta orthopaedica 1996, Vol.67 (4), p.389-392
Hauptverfasser:	Ikebe, Shuji, Masumi, Shogo, Yano, Hirokazu, Fukunaga, Tsutana, Shimizu, Kei, Shin, Shuta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Bone and Bones - blood supply Bone and Bones - drug effects Bone Transplantation - immunology Bone Transplantation - methods Dogs Female Ilium - transplantation Immunosuppressive Agents - pharmacology Male Medical sciences Neovascularization, Physiologic - drug effects Orthopedic surgery Pharmacology. Drug treatments Rabbits Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tacrolimus - pharmacology Transplantation, Heterologous
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