Evidence for pharmacologically distinct GABAB receptors associated with cAMP production in rat brain
Gamma-Aminobutyric acid-B (GABAB) receptors mediate a variety of cellular functions, suggesting the possibility of pharmacologically and molecularly distinct receptors. To explore this possibility a number of GABAB receptor agonists and antagonists were examined for their ability to influence cAMP p...
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| Veröffentlicht in: | Brain research 1996-05, Vol.720 (1-2), p.220-224 |
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| creator | CUNNINGHAM, M. D ENNA, S. J |
| description | Gamma-Aminobutyric acid-B (GABAB) receptors mediate a variety of cellular functions, suggesting the possibility of pharmacologically and molecularly distinct receptors. To explore this possibility a number of GABAB receptor agonists and antagonists were examined for their ability to influence cAMP production in rat brain cerebral cortical slices. While the agonists did not differentiate between receptors associated with the augmentation of isoproterenol-induced cAMP production and those mediating inhibition of forskolin-stimulated second messenger accumulation, significant differences were noted between the potencies of some antagonists to inhibit these GABAB receptor-mediated responses. The results suggest at least two pharmacologically distinct subclasses of GABAB receptors regulate cAMP production in brain. |
| doi_str_mv | 10.1016/0006-8993(96)00120-5 |
| format | Article |
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The results suggest at least two pharmacologically distinct subclasses of GABAB receptors regulate cAMP production in brain.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(96)00120-5</identifier><identifier>PMID: 8782915</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier</publisher><subject>Adrenergic beta-Agonists - pharmacology ; Animals ; Biological and medical sciences ; Brain Chemistry - drug effects ; Brain Chemistry - physiology ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Cerebral Cortex - cytology ; Cerebral Cortex - drug effects ; Cerebral Cortex - metabolism ; Colforsin - pharmacology ; Cyclic AMP - biosynthesis ; Fundamental and applied biological sciences. 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The results suggest at least two pharmacologically distinct subclasses of GABAB receptors regulate cAMP production in brain.</description><subject>Adrenergic beta-Agonists - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry - drug effects</subject><subject>Brain Chemistry - physiology</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Cerebral Cortex - cytology</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - metabolism</subject><subject>Colforsin - pharmacology</subject><subject>Cyclic AMP - biosynthesis</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>GABA-B Receptor Agonists</topic><topic>GABA-B Receptor Antagonists</topic><topic>In Vitro Techniques</topic><topic>Isoproterenol - pharmacology</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, GABA-B - metabolism</topic><topic>Signal Transduction - drug effects</topic><topic>Signal Transduction - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CUNNINGHAM, M. D</creatorcontrib><creatorcontrib>ENNA, S. 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| subjects | Adrenergic beta-Agonists - pharmacology Animals Biological and medical sciences Brain Chemistry - drug effects Brain Chemistry - physiology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Colforsin - pharmacology Cyclic AMP - biosynthesis Fundamental and applied biological sciences. Psychology GABA-B Receptor Agonists GABA-B Receptor Antagonists In Vitro Techniques Isoproterenol - pharmacology Male Rats Rats, Sprague-Dawley Receptors, GABA-B - metabolism Signal Transduction - drug effects Signal Transduction - physiology Vertebrates: nervous system and sense organs |
| title | Evidence for pharmacologically distinct GABAB receptors associated with cAMP production in rat brain |
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