Motor neuron syndrome and monoclonal IgM with antibody activity against gangliosides GM1 and GD1b
We demonstrated that an IgM M‐protein from a patient with motor neuron syndrome had antibody activity against gangliosides GM1, GD1b, and asialo GM1. Studies with a sugar‐binding lectin suggested that the epitope in the patient's M‐IgM involved the Gal(β1‐3) GalNAc moiety. Immunohistological te...
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| Veröffentlicht in: | Annals of neurology 1988-05, Vol.23 (5), p.524-528 |
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| container_end_page | 528 |
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| container_issue | 5 |
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| container_title | Annals of neurology |
| container_volume | 23 |
| creator | Nardelli, Ettore Steck, Andreas J. Barkas, Thomas Schluep, Myriam Jerusalem, Felix |
| description | We demonstrated that an IgM M‐protein from a patient with motor neuron syndrome had antibody activity against gangliosides GM1, GD1b, and asialo GM1. Studies with a sugar‐binding lectin suggested that the epitope in the patient's M‐IgM involved the Gal(β1‐3) GalNAc moiety. Immunohistological techniques demonstrated staining of axons in the lumbar roots, granular cells, and white matter in the cerebellum by the patient's M‐IgM. We propose that, in this case, an autoimmune mechanism of motor neuron syndrome associated with a monoclonal protein is most likely. |
| doi_str_mv | 10.1002/ana.410230517 |
| format | Article |
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Studies with a sugar‐binding lectin suggested that the epitope in the patient's M‐IgM involved the Gal(β1‐3) GalNAc moiety. Immunohistological techniques demonstrated staining of axons in the lumbar roots, granular cells, and white matter in the cerebellum by the patient's M‐IgM. We propose that, in this case, an autoimmune mechanism of motor neuron syndrome associated with a monoclonal protein is most likely.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.410230517</identifier><identifier>PMID: 3389760</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Antibodies, Monoclonal - blood ; Antibodies, Monoclonal - metabolism ; Autoantibodies - blood ; Autoantibodies - metabolism ; Biological and medical sciences ; Brain - immunology ; Female ; G(M1) Ganglioside - immunology ; Gangliosides - immunology ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Motor Neurons - immunology ; Neuromuscular Diseases - immunology ; Spinal Cord - immunology ; Syndrome ; Tumors</subject><ispartof>Annals of neurology, 1988-05, Vol.23 (5), p.524-528</ispartof><rights>Copyright © 1988 American Neurological Association</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4327-7226b6d4578f8315b1cd299b2ddee7a6687bd2f713065bd986d9bcf7808d0c783</citedby><cites>FETCH-LOGICAL-c4327-7226b6d4578f8315b1cd299b2ddee7a6687bd2f713065bd986d9bcf7808d0c783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.410230517$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.410230517$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7066695$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3389760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nardelli, Ettore</creatorcontrib><creatorcontrib>Steck, Andreas J.</creatorcontrib><creatorcontrib>Barkas, Thomas</creatorcontrib><creatorcontrib>Schluep, Myriam</creatorcontrib><creatorcontrib>Jerusalem, Felix</creatorcontrib><title>Motor neuron syndrome and monoclonal IgM with antibody activity against gangliosides GM1 and GD1b</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>We demonstrated that an IgM M‐protein from a patient with motor neuron syndrome had antibody activity against gangliosides GM1, GD1b, and asialo GM1. Studies with a sugar‐binding lectin suggested that the epitope in the patient's M‐IgM involved the Gal(β1‐3) GalNAc moiety. Immunohistological techniques demonstrated staining of axons in the lumbar roots, granular cells, and white matter in the cerebellum by the patient's M‐IgM. We propose that, in this case, an autoimmune mechanism of motor neuron syndrome associated with a monoclonal protein is most likely.</description><subject>Antibodies, Monoclonal - blood</subject><subject>Antibodies, Monoclonal - metabolism</subject><subject>Autoantibodies - blood</subject><subject>Autoantibodies - metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - immunology</subject><subject>Female</subject><subject>G(M1) Ganglioside - immunology</subject><subject>Gangliosides - immunology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motor Neurons - immunology</subject><subject>Neuromuscular Diseases - immunology</subject><subject>Spinal Cord - immunology</subject><subject>Syndrome</subject><subject>Tumors</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtvEzEQxi1EVdLAkSOSD4jbFj92_TiG0qSVknAAxNHya4Nh127tTdv89yxkFfXEaUbz_eab0QfAW4wuMULko476ssaIUNRg_gLMcENxJUgtX4IZoqyuGkzrV-CilF8IIckwOgfnlArJGZoBvUlDyjD6fU4RlkN0OfUe6uhgn2KyXYq6g7e7DXwMw89xPgST3AFqO4SHMIzNTodYBrjTcdeFVILzBa42-J_F6jM2r8FZq7vi30x1Dr4vr79d3VTrL6vbq8W6sjUlvOKEMMNc3XDRCoobg60jUhrinPdcMya4caTlmCLWGCcFc9LYlgskHLJc0Dn4cPS9y-l-78ug-lCs7zodfdoXxQWRDRn356A6gjanUrJv1V0Ovc4HhZH6G6kaI1WnSEf-3WS8N713J3rKcNTfT7ouVndt1tGGcsI4YozJZsT4EXsMnT_8_6ZabBfPH5geDmXwT6dNnX8rxilv1I_tSm2XS_xVrD-pG_oHEsudMQ</recordid><startdate>198805</startdate><enddate>198805</enddate><creator>Nardelli, Ettore</creator><creator>Steck, Andreas J.</creator><creator>Barkas, Thomas</creator><creator>Schluep, Myriam</creator><creator>Jerusalem, Felix</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198805</creationdate><title>Motor neuron syndrome and monoclonal IgM with antibody activity against gangliosides GM1 and GD1b</title><author>Nardelli, Ettore ; Steck, Andreas J. ; Barkas, Thomas ; Schluep, Myriam ; Jerusalem, Felix</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4327-7226b6d4578f8315b1cd299b2ddee7a6687bd2f713065bd986d9bcf7808d0c783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Antibodies, Monoclonal - blood</topic><topic>Antibodies, Monoclonal - metabolism</topic><topic>Autoantibodies - blood</topic><topic>Autoantibodies - metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - immunology</topic><topic>Female</topic><topic>G(M1) Ganglioside - immunology</topic><topic>Gangliosides - immunology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor Neurons - immunology</topic><topic>Neuromuscular Diseases - immunology</topic><topic>Spinal Cord - immunology</topic><topic>Syndrome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nardelli, Ettore</creatorcontrib><creatorcontrib>Steck, Andreas J.</creatorcontrib><creatorcontrib>Barkas, Thomas</creatorcontrib><creatorcontrib>Schluep, Myriam</creatorcontrib><creatorcontrib>Jerusalem, Felix</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nardelli, Ettore</au><au>Steck, Andreas J.</au><au>Barkas, Thomas</au><au>Schluep, Myriam</au><au>Jerusalem, Felix</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Motor neuron syndrome and monoclonal IgM with antibody activity against gangliosides GM1 and GD1b</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>1988-05</date><risdate>1988</risdate><volume>23</volume><issue>5</issue><spage>524</spage><epage>528</epage><pages>524-528</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>We demonstrated that an IgM M‐protein from a patient with motor neuron syndrome had antibody activity against gangliosides GM1, GD1b, and asialo GM1. Studies with a sugar‐binding lectin suggested that the epitope in the patient's M‐IgM involved the Gal(β1‐3) GalNAc moiety. Immunohistological techniques demonstrated staining of axons in the lumbar roots, granular cells, and white matter in the cerebellum by the patient's M‐IgM. We propose that, in this case, an autoimmune mechanism of motor neuron syndrome associated with a monoclonal protein is most likely.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3389760</pmid><doi>10.1002/ana.410230517</doi><tpages>5</tpages></addata></record> |
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| ispartof | Annals of neurology, 1988-05, Vol.23 (5), p.524-528 |
| issn | 0364-5134 1531-8249 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Antibodies, Monoclonal - blood Antibodies, Monoclonal - metabolism Autoantibodies - blood Autoantibodies - metabolism Biological and medical sciences Brain - immunology Female G(M1) Ganglioside - immunology Gangliosides - immunology Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Middle Aged Motor Neurons - immunology Neuromuscular Diseases - immunology Spinal Cord - immunology Syndrome Tumors |
| title | Motor neuron syndrome and monoclonal IgM with antibody activity against gangliosides GM1 and GD1b |
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