THE EFFECT OF CISAPRIDE ON INTESTINAL TRANSIT
Cisapride is known to accelerate gastrointestinal motility in various diseases with gastrointestinal motor abnormalities, and in normal subjects. In this study, we developed a new method to evaluate intestinal transit by radio-opaque markers, and evaluated the effect of oral doses of cisapride on in...
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| Veröffentlicht in: | Japanese Journal of Smooth Muscle Research 1988, Vol.24(1), pp.55-60 |
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| container_title | Japanese Journal of Smooth Muscle Research |
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| creator | SATAKE, Kenzo HONGO, Michio UJIIE, Hiroaki OKUNO, Yo GOTO, Yoshio |
| description | Cisapride is known to accelerate gastrointestinal motility in various diseases with gastrointestinal motor abnormalities, and in normal subjects. In this study, we developed a new method to evaluate intestinal transit by radio-opaque markers, and evaluated the effect of oral doses of cisapride on intestinal transit in 6 normal subjects. Twenty markers were ingested with breakfast, and abdominal X-ray pictures were taken at 6, 24, 48 and 72 hours later, markers on the films were scored according to estimated their location. Geometric mean of the markers and half-dose transit-time (HT) at selected points of the colon were calculated. Cisapride 7.5 mg, 15 mg per day or placebo were given in random order, in double blind fashion. Cisapride accelerated intestinal transit at every point calculated. HT at anus was shortened to 23.3±10.2 hours (mean+SD) (p |
| doi_str_mv | 10.1540/jsmr1965.24.55 |
| format | Article |
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In this study, we developed a new method to evaluate intestinal transit by radio-opaque markers, and evaluated the effect of oral doses of cisapride on intestinal transit in 6 normal subjects. Twenty markers were ingested with breakfast, and abdominal X-ray pictures were taken at 6, 24, 48 and 72 hours later, markers on the films were scored according to estimated their location. Geometric mean of the markers and half-dose transit-time (HT) at selected points of the colon were calculated. Cisapride 7.5 mg, 15 mg per day or placebo were given in random order, in double blind fashion. Cisapride accelerated intestinal transit at every point calculated. HT at anus was shortened to 23.3±10.2 hours (mean+SD) (p<0.05) with cisapride 15 mg/day from 42.3±16.9 hours with placebo. Geometric means at 24-hour were 3.7±1.4 with placebo, 5.3±0.9 (p<0.05) with cisapride 7.5 mg/day, and 5.1±1.5 with cisapride 15 mg/day. No serious side effects were noted. Our new method to evaluate intestinal transit using radio-opaque markers is easy to perform, and is able to quantify the state of transit. Cisapride accelerated intestinal transit without diarrhea. This effect of cisapride on intestinal transit may be useful in patients with constipation.</description><identifier>ISSN: 0374-3527</identifier><identifier>EISSN: 1884-8788</identifier><identifier>DOI: 10.1540/jsmr1965.24.55</identifier><identifier>PMID: 3386087</identifier><language>eng ; jpn</language><publisher>Japan: Japan Society of Smooth Muscle Research</publisher><subject>Administration, Oral ; Adult ; Cisapride ; Contrast Media ; Digestive System - diagnostic imaging ; Digestive System - drug effects ; Double-Blind Method ; Female ; Gastrointestinal Transit - drug effects ; Humans ; Male ; Piperidines - administration & dosage ; Piperidines - pharmacology ; Radiography ; Time Factors</subject><ispartof>Japanese Journal of Smooth Muscle Research, 1988, Vol.24(1), pp.55-60</ispartof><rights>Japan Society of Smooth Muscle Research</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3625-eb32c827a0c8ed8a3a321470776b455aa40d5d5d2b232caf50a2de089001e27b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3386087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SATAKE, Kenzo</creatorcontrib><creatorcontrib>HONGO, Michio</creatorcontrib><creatorcontrib>UJIIE, Hiroaki</creatorcontrib><creatorcontrib>OKUNO, Yo</creatorcontrib><creatorcontrib>GOTO, Yoshio</creatorcontrib><title>THE EFFECT OF CISAPRIDE ON INTESTINAL TRANSIT</title><title>Japanese Journal of Smooth Muscle Research</title><addtitle>Jpn. J. Smooth Muscle Res.</addtitle><description>Cisapride is known to accelerate gastrointestinal motility in various diseases with gastrointestinal motor abnormalities, and in normal subjects. In this study, we developed a new method to evaluate intestinal transit by radio-opaque markers, and evaluated the effect of oral doses of cisapride on intestinal transit in 6 normal subjects. Twenty markers were ingested with breakfast, and abdominal X-ray pictures were taken at 6, 24, 48 and 72 hours later, markers on the films were scored according to estimated their location. Geometric mean of the markers and half-dose transit-time (HT) at selected points of the colon were calculated. Cisapride 7.5 mg, 15 mg per day or placebo were given in random order, in double blind fashion. Cisapride accelerated intestinal transit at every point calculated. HT at anus was shortened to 23.3±10.2 hours (mean+SD) (p<0.05) with cisapride 15 mg/day from 42.3±16.9 hours with placebo. Geometric means at 24-hour were 3.7±1.4 with placebo, 5.3±0.9 (p<0.05) with cisapride 7.5 mg/day, and 5.1±1.5 with cisapride 15 mg/day. No serious side effects were noted. Our new method to evaluate intestinal transit using radio-opaque markers is easy to perform, and is able to quantify the state of transit. Cisapride accelerated intestinal transit without diarrhea. This effect of cisapride on intestinal transit may be useful in patients with constipation.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Cisapride</subject><subject>Contrast Media</subject><subject>Digestive System - diagnostic imaging</subject><subject>Digestive System - drug effects</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Gastrointestinal Transit - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Piperidines - administration & dosage</subject><subject>Piperidines - pharmacology</subject><subject>Radiography</subject><subject>Time Factors</subject><issn>0374-3527</issn><issn>1884-8788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkD1PwzAURS0EKlXpyoaUiS3BXy92xygkNFKVojbMluO40CppwW4H_j1BKZXwk_yGc94dLkL3BEcEOH7a-c6RWQwR5RHAFRoTKXkohZTXaIyZ4CEDKm7R1Psd7l9MKEA8QiPGZIylGKOwmmdBludZWgXLPEiLdfK6Kp6zYFkGRVll66ook0VQrZJyXVR36GajW2-n5z1Bb3lWpfNwsXwp0mQRGhZTCG3NqJFUaGykbaRmmlHCBRYirjmA1hw30A-taS_qDWBNG4vlDGNiqajZBD0OuZ_u8HWy_qi6rTe2bfXeHk5eCUlnXAjWi9EgGnfw3tmN-nTbTrtvRbD6rUj9VaQoVwD9wcM5-VR3trno50J6ng5854_63V64dsetae2_ODJ8ABdqPrRTds9-AGWWc_g</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>SATAKE, Kenzo</creator><creator>HONGO, Michio</creator><creator>UJIIE, Hiroaki</creator><creator>OKUNO, Yo</creator><creator>GOTO, Yoshio</creator><general>Japan Society of Smooth Muscle Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>THE EFFECT OF CISAPRIDE ON INTESTINAL TRANSIT</title><author>SATAKE, Kenzo ; HONGO, Michio ; UJIIE, Hiroaki ; OKUNO, Yo ; GOTO, Yoshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3625-eb32c827a0c8ed8a3a321470776b455aa40d5d5d2b232caf50a2de089001e27b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>1988</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Cisapride</topic><topic>Contrast Media</topic><topic>Digestive System - diagnostic imaging</topic><topic>Digestive System - drug effects</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Gastrointestinal Transit - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Piperidines - administration & dosage</topic><topic>Piperidines - pharmacology</topic><topic>Radiography</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>SATAKE, Kenzo</creatorcontrib><creatorcontrib>HONGO, Michio</creatorcontrib><creatorcontrib>UJIIE, Hiroaki</creatorcontrib><creatorcontrib>OKUNO, Yo</creatorcontrib><creatorcontrib>GOTO, Yoshio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Journal of Smooth Muscle Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SATAKE, Kenzo</au><au>HONGO, Michio</au><au>UJIIE, Hiroaki</au><au>OKUNO, Yo</au><au>GOTO, Yoshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE EFFECT OF CISAPRIDE ON INTESTINAL TRANSIT</atitle><jtitle>Japanese Journal of Smooth Muscle Research</jtitle><addtitle>Jpn. J. Smooth Muscle Res.</addtitle><date>1988</date><risdate>1988</risdate><volume>24</volume><issue>1</issue><spage>55</spage><epage>60</epage><pages>55-60</pages><issn>0374-3527</issn><eissn>1884-8788</eissn><abstract>Cisapride is known to accelerate gastrointestinal motility in various diseases with gastrointestinal motor abnormalities, and in normal subjects. In this study, we developed a new method to evaluate intestinal transit by radio-opaque markers, and evaluated the effect of oral doses of cisapride on intestinal transit in 6 normal subjects. Twenty markers were ingested with breakfast, and abdominal X-ray pictures were taken at 6, 24, 48 and 72 hours later, markers on the films were scored according to estimated their location. Geometric mean of the markers and half-dose transit-time (HT) at selected points of the colon were calculated. Cisapride 7.5 mg, 15 mg per day or placebo were given in random order, in double blind fashion. Cisapride accelerated intestinal transit at every point calculated. HT at anus was shortened to 23.3±10.2 hours (mean+SD) (p<0.05) with cisapride 15 mg/day from 42.3±16.9 hours with placebo. Geometric means at 24-hour were 3.7±1.4 with placebo, 5.3±0.9 (p<0.05) with cisapride 7.5 mg/day, and 5.1±1.5 with cisapride 15 mg/day. No serious side effects were noted. Our new method to evaluate intestinal transit using radio-opaque markers is easy to perform, and is able to quantify the state of transit. Cisapride accelerated intestinal transit without diarrhea. This effect of cisapride on intestinal transit may be useful in patients with constipation.</abstract><cop>Japan</cop><pub>Japan Society of Smooth Muscle Research</pub><pmid>3386087</pmid><doi>10.1540/jsmr1965.24.55</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0374-3527 |
| ispartof | Japanese Journal of Smooth Muscle Research, 1988, Vol.24(1), pp.55-60 |
| issn | 0374-3527 1884-8788 |
| language | eng ; jpn |
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| source | J-STAGE Free; MEDLINE |
| subjects | Administration, Oral Adult Cisapride Contrast Media Digestive System - diagnostic imaging Digestive System - drug effects Double-Blind Method Female Gastrointestinal Transit - drug effects Humans Male Piperidines - administration & dosage Piperidines - pharmacology Radiography Time Factors |
| title | THE EFFECT OF CISAPRIDE ON INTESTINAL TRANSIT |
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