EFFECT OF CISAPRIDE ON DELAYED GASTRIC EMPTYING IN DIABETIC PATIENTS
Delayed gastric emptying is supposed to affect glycemic control in diabetic patients by relative over dosing of insulin to blood glucose level due to delayed absorption of nutrients. Therefore, treatment of delayed gastric emptying is important in diabetic patients. Cisapride, a potent gastrokinetic...
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| Veröffentlicht in: | Japanese Journal of Smooth Muscle Research 1988, Vol.24(1), pp.47-53 |
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| container_title | Japanese Journal of Smooth Muscle Research |
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| creator | LIN, Yih-Fong HONGO, Michio SATAKE, Kenzo UJIIE, Hiroaki TOYOTA, Takayoshi GOTO, Yoshio OKUYAMA, Shinichi |
| description | Delayed gastric emptying is supposed to affect glycemic control in diabetic patients by relative over dosing of insulin to blood glucose level due to delayed absorption of nutrients. Therefore, treatment of delayed gastric emptying is important in diabetic patients. Cisapride, a potent gastrokinetic agents, has been reported to activate the motility from stomach to colon. We evaluated the effect of acute oral administration of cisapride in seven diabetic patients (aged 46-62) with delayed gastric emptying. All patients complicated with autonomic neuropathy. Ten mg of cisapride was administered orally 30 minutes before breakfast and lunch on the day of study. Gastric emptying study was done using 99mTc- tin colloid labeled omelet meal served with 2 slices of toast and 200 ml of milk. With cisapride, the retention rate at time of 150 minutes decreased from 76±10% to 47±13% (mean±SD) (p0.1). Blood glucose level before meal decreased from 117±27 mg/dl (mean±SE) to 74±7 mg/dl (n.s.), and difference between basal and maximal blood glucose level became larger from 46±27mg/dl to 84±30mg/dl (n.s.). We conclude that acute oral administration of cisapride has significant effect in improving delayed emptying of solid meal in diabetic patients. |
| doi_str_mv | 10.1540/jsmr1965.24.47 |
| format | Article |
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Therefore, treatment of delayed gastric emptying is important in diabetic patients. Cisapride, a potent gastrokinetic agents, has been reported to activate the motility from stomach to colon. We evaluated the effect of acute oral administration of cisapride in seven diabetic patients (aged 46-62) with delayed gastric emptying. All patients complicated with autonomic neuropathy. Ten mg of cisapride was administered orally 30 minutes before breakfast and lunch on the day of study. Gastric emptying study was done using 99mTc- tin colloid labeled omelet meal served with 2 slices of toast and 200 ml of milk. With cisapride, the retention rate at time of 150 minutes decreased from 76±10% to 47±13% (mean±SD) (p<0.001) and starting index shortened from 86±28 minutes to 38±27 minutes (p<0.05). Gastric emptying speed became faster from 0.31±0.16% /min to 0.43±0.12%/min (0.2>p>0.1). Blood glucose level before meal decreased from 117±27 mg/dl (mean±SE) to 74±7 mg/dl (n.s.), and difference between basal and maximal blood glucose level became larger from 46±27mg/dl to 84±30mg/dl (n.s.). We conclude that acute oral administration of cisapride has significant effect in improving delayed emptying of solid meal in diabetic patients.</description><identifier>ISSN: 0374-3527</identifier><identifier>EISSN: 1884-8788</identifier><identifier>DOI: 10.1540/jsmr1965.24.47</identifier><identifier>PMID: 3386086</identifier><language>eng ; jpn</language><publisher>Japan: Japan Society of Smooth Muscle Research</publisher><subject>Administration, Oral ; Blood Glucose - metabolism ; Cisapride ; Diabetes Mellitus - metabolism ; Diabetes Mellitus - physiopathology ; Female ; Gastric Emptying - drug effects ; Humans ; Male ; Middle Aged ; Piperidines - administration & dosage ; Piperidines - pharmacology ; Radionuclide Imaging ; Stomach - diagnostic imaging ; Stomach - drug effects ; Time Factors</subject><ispartof>Japanese Journal of Smooth Muscle Research, 1988, Vol.24(1), pp.47-53</ispartof><rights>Japan Society of Smooth Muscle Research</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1879,4012,27906,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3386086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LIN, Yih-Fong</creatorcontrib><creatorcontrib>HONGO, Michio</creatorcontrib><creatorcontrib>SATAKE, Kenzo</creatorcontrib><creatorcontrib>UJIIE, Hiroaki</creatorcontrib><creatorcontrib>TOYOTA, Takayoshi</creatorcontrib><creatorcontrib>GOTO, Yoshio</creatorcontrib><creatorcontrib>OKUYAMA, Shinichi</creatorcontrib><title>EFFECT OF CISAPRIDE ON DELAYED GASTRIC EMPTYING IN DIABETIC PATIENTS</title><title>Japanese Journal of Smooth Muscle Research</title><addtitle>Jpn. J. Smooth Muscle Res.</addtitle><description>Delayed gastric emptying is supposed to affect glycemic control in diabetic patients by relative over dosing of insulin to blood glucose level due to delayed absorption of nutrients. Therefore, treatment of delayed gastric emptying is important in diabetic patients. Cisapride, a potent gastrokinetic agents, has been reported to activate the motility from stomach to colon. We evaluated the effect of acute oral administration of cisapride in seven diabetic patients (aged 46-62) with delayed gastric emptying. All patients complicated with autonomic neuropathy. Ten mg of cisapride was administered orally 30 minutes before breakfast and lunch on the day of study. Gastric emptying study was done using 99mTc- tin colloid labeled omelet meal served with 2 slices of toast and 200 ml of milk. With cisapride, the retention rate at time of 150 minutes decreased from 76±10% to 47±13% (mean±SD) (p<0.001) and starting index shortened from 86±28 minutes to 38±27 minutes (p<0.05). Gastric emptying speed became faster from 0.31±0.16% /min to 0.43±0.12%/min (0.2>p>0.1). Blood glucose level before meal decreased from 117±27 mg/dl (mean±SE) to 74±7 mg/dl (n.s.), and difference between basal and maximal blood glucose level became larger from 46±27mg/dl to 84±30mg/dl (n.s.). We conclude that acute oral administration of cisapride has significant effect in improving delayed emptying of solid meal in diabetic patients.</description><subject>Administration, Oral</subject><subject>Blood Glucose - metabolism</subject><subject>Cisapride</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Female</subject><subject>Gastric Emptying - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Piperidines - administration & dosage</subject><subject>Piperidines - pharmacology</subject><subject>Radionuclide Imaging</subject><subject>Stomach - diagnostic imaging</subject><subject>Stomach - drug effects</subject><subject>Time Factors</subject><issn>0374-3527</issn><issn>1884-8788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEFPwjAYhhujQYJcvZns5G24rt3aHufW4RIEAvPAqelKq5ANsIWD_96RIYnfoV_S582TfC8AjzAYwQgHL1vXWMjiaBTiESY3oA8pxT4llN6CfoAI9lEUknswdG4btBPDMIriHughROOAxn2Q8TznaenNci8tlsl8UWTcm029jE-SFc-8cbIsF0Xq8fd5uSqmY69oWZG88rL9nCdlwafl8gHcGVk7PbzsAfjIeZm--ZPZuEiTia8QJMRnxhhKK4UMMlWoETPtDWuDIYw00yrUjEq4RiiElaYsIkqqgFKGYEUUjAKCBuC58x7s_vuk3VE0G6d0Xcud3p-cIDRkGBHaBkddUNm9c1YbcbCbRtofAQNxbk78NSdCLPDZ_HQxn6pGr6_xS08tTzu-dUf5qa9c2uNG1fqfDnYPJleqvqQVeod-AZeIeoY</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>LIN, Yih-Fong</creator><creator>HONGO, Michio</creator><creator>SATAKE, Kenzo</creator><creator>UJIIE, Hiroaki</creator><creator>TOYOTA, Takayoshi</creator><creator>GOTO, Yoshio</creator><creator>OKUYAMA, Shinichi</creator><general>Japan Society of Smooth Muscle Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>EFFECT OF CISAPRIDE ON DELAYED GASTRIC EMPTYING IN DIABETIC PATIENTS</title><author>LIN, Yih-Fong ; HONGO, Michio ; SATAKE, Kenzo ; UJIIE, Hiroaki ; TOYOTA, Takayoshi ; GOTO, Yoshio ; OKUYAMA, Shinichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3177-9fff88bc3f3fb2e39f540df4115e9ec2e98a1d3321be8957cac088931b7c15073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>1988</creationdate><topic>Administration, Oral</topic><topic>Blood Glucose - metabolism</topic><topic>Cisapride</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Female</topic><topic>Gastric Emptying - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Piperidines - administration & dosage</topic><topic>Piperidines - pharmacology</topic><topic>Radionuclide Imaging</topic><topic>Stomach - diagnostic imaging</topic><topic>Stomach - drug effects</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>LIN, Yih-Fong</creatorcontrib><creatorcontrib>HONGO, Michio</creatorcontrib><creatorcontrib>SATAKE, Kenzo</creatorcontrib><creatorcontrib>UJIIE, Hiroaki</creatorcontrib><creatorcontrib>TOYOTA, Takayoshi</creatorcontrib><creatorcontrib>GOTO, Yoshio</creatorcontrib><creatorcontrib>OKUYAMA, Shinichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Journal of Smooth Muscle Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIN, Yih-Fong</au><au>HONGO, Michio</au><au>SATAKE, Kenzo</au><au>UJIIE, Hiroaki</au><au>TOYOTA, Takayoshi</au><au>GOTO, Yoshio</au><au>OKUYAMA, Shinichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECT OF CISAPRIDE ON DELAYED GASTRIC EMPTYING IN DIABETIC PATIENTS</atitle><jtitle>Japanese Journal of Smooth Muscle Research</jtitle><addtitle>Jpn. J. Smooth Muscle Res.</addtitle><date>1988</date><risdate>1988</risdate><volume>24</volume><issue>1</issue><spage>47</spage><epage>53</epage><pages>47-53</pages><issn>0374-3527</issn><eissn>1884-8788</eissn><abstract>Delayed gastric emptying is supposed to affect glycemic control in diabetic patients by relative over dosing of insulin to blood glucose level due to delayed absorption of nutrients. Therefore, treatment of delayed gastric emptying is important in diabetic patients. Cisapride, a potent gastrokinetic agents, has been reported to activate the motility from stomach to colon. We evaluated the effect of acute oral administration of cisapride in seven diabetic patients (aged 46-62) with delayed gastric emptying. All patients complicated with autonomic neuropathy. Ten mg of cisapride was administered orally 30 minutes before breakfast and lunch on the day of study. Gastric emptying study was done using 99mTc- tin colloid labeled omelet meal served with 2 slices of toast and 200 ml of milk. With cisapride, the retention rate at time of 150 minutes decreased from 76±10% to 47±13% (mean±SD) (p<0.001) and starting index shortened from 86±28 minutes to 38±27 minutes (p<0.05). Gastric emptying speed became faster from 0.31±0.16% /min to 0.43±0.12%/min (0.2>p>0.1). Blood glucose level before meal decreased from 117±27 mg/dl (mean±SE) to 74±7 mg/dl (n.s.), and difference between basal and maximal blood glucose level became larger from 46±27mg/dl to 84±30mg/dl (n.s.). We conclude that acute oral administration of cisapride has significant effect in improving delayed emptying of solid meal in diabetic patients.</abstract><cop>Japan</cop><pub>Japan Society of Smooth Muscle Research</pub><pmid>3386086</pmid><doi>10.1540/jsmr1965.24.47</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Japanese Journal of Smooth Muscle Research, 1988, Vol.24(1), pp.47-53 |
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| language | eng ; jpn |
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| source | J-STAGE Free; MEDLINE |
| subjects | Administration, Oral Blood Glucose - metabolism Cisapride Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Female Gastric Emptying - drug effects Humans Male Middle Aged Piperidines - administration & dosage Piperidines - pharmacology Radionuclide Imaging Stomach - diagnostic imaging Stomach - drug effects Time Factors |
| title | EFFECT OF CISAPRIDE ON DELAYED GASTRIC EMPTYING IN DIABETIC PATIENTS |
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