Antigenic relationship between human and animal adenovirus hexons determined by means of monoclonal antibodies directed against bovine adenovirus type 2 hexon
Eight monoclonal antibodies (MAbs) directed against bovine adenovirus (BAV) 2 subtype B hexon were studied with 12 different hexon types of human adenoviruses (AV) belonging to 5 different subgenera using indirect ELISA, passive hemagglutination (HA), and gel diffusion assays. Two hexon types of ani...
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| Veröffentlicht in: | Archives of virology 1988-01, Vol.100 (1/2), p.9-15 |
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| creator | Adam, E Rusvai, M Lengyel, A Belak, S Nasz, I |
| description | Eight monoclonal antibodies (MAbs) directed against bovine adenovirus (BAV) 2 subtype B hexon were studied with 12 different hexon types of human adenoviruses (AV) belonging to 5 different subgenera using indirect ELISA, passive hemagglutination (HA), and gel diffusion assays. Two hexon types of animal origin (BAV3 and SAV16) were investigated, too. The reactivity of the MAb IV.F3 was the broadest, i.e. in ELISA and HA experiments it reacted with all hexon types studied. Based on these results as well as on the results of gel diffusion assays, this MAb should recognize the genus specific epitope of adenovirus hexons. Three MAbs (CA12, III.B11, and A12) could recognize different epitopes showing intersubgenus or intertype specificities. In spite of the fact, that all the eight MAbs proved to be bound by the hexon of ORT/111 (BAV2 subtype B) blotted onto nitrocellulose filter, four of the eight MAbs (BB7, BH5, II.A9, and IV.F5) failed to react with any human, and animal hexon types used in the present experiments. The results suggest that a gradient of antigenic relationship may exist between BAV2 hexon and the hexons of human serotypes. |
| doi_str_mv | 10.1007/BF01310903 |
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Two hexon types of animal origin (BAV3 and SAV16) were investigated, too. The reactivity of the MAb IV.F3 was the broadest, i.e. in ELISA and HA experiments it reacted with all hexon types studied. Based on these results as well as on the results of gel diffusion assays, this MAb should recognize the genus specific epitope of adenovirus hexons. Three MAbs (CA12, III.B11, and A12) could recognize different epitopes showing intersubgenus or intertype specificities. In spite of the fact, that all the eight MAbs proved to be bound by the hexon of ORT/111 (BAV2 subtype B) blotted onto nitrocellulose filter, four of the eight MAbs (BB7, BH5, II.A9, and IV.F5) failed to react with any human, and animal hexon types used in the present experiments. The results suggest that a gradient of antigenic relationship may exist between BAV2 hexon and the hexons of human serotypes.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/BF01310903</identifier><identifier>PMID: 2455494</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Adenoviridae ; Adenoviridae - classification ; Adenoviridae - immunology ; Adenoviruses, Human - classification ; Adenoviruses, Human - immunology ; Animals ; Antibodies, Monoclonal ; antigens ; Antigens, Viral - analysis ; Biological and medical sciences ; bovine adenovirus ; Capsid - immunology ; Enzyme-Linked Immunosorbent Assay ; Epitopes - analysis ; Fundamental and applied biological sciences. Psychology ; genetic variation ; Hemagglutination Tests ; Humans ; Immunodiffusion ; Microbiology ; monoclonal antibodies ; Morphology, structure, chemical composition, physicochemical properties ; Virology</subject><ispartof>Archives of virology, 1988-01, Vol.100 (1/2), p.9-15</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-7028f821a43294afe5e5c3acee620d46c4de92ce108389122d4ea385436bfad93</citedby><cites>FETCH-LOGICAL-c366t-7028f821a43294afe5e5c3acee620d46c4de92ce108389122d4ea385436bfad93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6989660$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2455494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adam, E</creatorcontrib><creatorcontrib>Rusvai, M</creatorcontrib><creatorcontrib>Lengyel, A</creatorcontrib><creatorcontrib>Belak, S</creatorcontrib><creatorcontrib>Nasz, I</creatorcontrib><title>Antigenic relationship between human and animal adenovirus hexons determined by means of monoclonal antibodies directed against bovine adenovirus type 2 hexon</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><description>Eight monoclonal antibodies (MAbs) directed against bovine adenovirus (BAV) 2 subtype B hexon were studied with 12 different hexon types of human adenoviruses (AV) belonging to 5 different subgenera using indirect ELISA, passive hemagglutination (HA), and gel diffusion assays. Two hexon types of animal origin (BAV3 and SAV16) were investigated, too. The reactivity of the MAb IV.F3 was the broadest, i.e. in ELISA and HA experiments it reacted with all hexon types studied. Based on these results as well as on the results of gel diffusion assays, this MAb should recognize the genus specific epitope of adenovirus hexons. Three MAbs (CA12, III.B11, and A12) could recognize different epitopes showing intersubgenus or intertype specificities. In spite of the fact, that all the eight MAbs proved to be bound by the hexon of ORT/111 (BAV2 subtype B) blotted onto nitrocellulose filter, four of the eight MAbs (BB7, BH5, II.A9, and IV.F5) failed to react with any human, and animal hexon types used in the present experiments. The results suggest that a gradient of antigenic relationship may exist between BAV2 hexon and the hexons of human serotypes.</description><subject>Adenoviridae</subject><subject>Adenoviridae - classification</subject><subject>Adenoviridae - immunology</subject><subject>Adenoviruses, Human - classification</subject><subject>Adenoviruses, Human - immunology</subject><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>antigens</subject><subject>Antigens, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>bovine adenovirus</subject><subject>Capsid - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epitopes - analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>genetic variation</subject><subject>Hemagglutination Tests</subject><subject>Humans</subject><subject>Immunodiffusion</subject><subject>Microbiology</subject><subject>monoclonal antibodies</subject><subject>Morphology, structure, chemical composition, physicochemical properties</subject><subject>Virology</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo67h68S7mIB6E0Xx1Jn3cXVwVFjzonpvqpHom0p2MSbc6f8bfai0zrN6EhEDVk-clKcaeS_FWCrF5d3ktpJaiFfoBW0mj1dptWveQrYQWZu2scI_Zk1q_CUEF3ZyxM2WaxrRmxX5fpDluMUXPC44wx5zqLu55j_NPxMR3ywSJQwq04wQjh4Ap_4hlqXyHv4jmAWcsU0wYeH_gEwLV8sCnnLIfc7q7Qxl9DhEJjgX9TChsIaY6855kCf_Vzoc9cnW0P2WPBhgrPjud5-z2-v3Xq4_rm88fPl1d3Ky9tnZeb4Ryg1MS6O2tgQEbbLwGj2iVCMZ6E7BVHqVw2rVSqWAQtGuMtv0AodXn7PXRuy_5-4J17qZYPY4jJMxL7TaOvLT-C8pGSkkZBL45gr7kWgsO3b7QB5ZDJ0V3N7Xu79QIfnGyLv2E4R49jYn6r059qB7GoUDysd5jtnWttYKwl0dsgNzBthBy-0VRipBGNNZq_QeEwKro</recordid><startdate>19880101</startdate><enddate>19880101</enddate><creator>Adam, E</creator><creator>Rusvai, M</creator><creator>Lengyel, A</creator><creator>Belak, S</creator><creator>Nasz, I</creator><general>Springer</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19880101</creationdate><title>Antigenic relationship between human and animal adenovirus hexons determined by means of monoclonal antibodies directed against bovine adenovirus type 2 hexon</title><author>Adam, E ; Rusvai, M ; Lengyel, A ; Belak, S ; Nasz, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-7028f821a43294afe5e5c3acee620d46c4de92ce108389122d4ea385436bfad93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adenoviridae</topic><topic>Adenoviridae - classification</topic><topic>Adenoviridae - immunology</topic><topic>Adenoviruses, Human - classification</topic><topic>Adenoviruses, Human - immunology</topic><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>antigens</topic><topic>Antigens, Viral - analysis</topic><topic>Biological and medical sciences</topic><topic>bovine adenovirus</topic><topic>Capsid - immunology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Epitopes - analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>genetic variation</topic><topic>Hemagglutination Tests</topic><topic>Humans</topic><topic>Immunodiffusion</topic><topic>Microbiology</topic><topic>monoclonal antibodies</topic><topic>Morphology, structure, chemical composition, physicochemical properties</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adam, E</creatorcontrib><creatorcontrib>Rusvai, M</creatorcontrib><creatorcontrib>Lengyel, A</creatorcontrib><creatorcontrib>Belak, S</creatorcontrib><creatorcontrib>Nasz, I</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adam, E</au><au>Rusvai, M</au><au>Lengyel, A</au><au>Belak, S</au><au>Nasz, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antigenic relationship between human and animal adenovirus hexons determined by means of monoclonal antibodies directed against bovine adenovirus type 2 hexon</atitle><jtitle>Archives of virology</jtitle><addtitle>Arch Virol</addtitle><date>1988-01-01</date><risdate>1988</risdate><volume>100</volume><issue>1/2</issue><spage>9</spage><epage>15</epage><pages>9-15</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>Eight monoclonal antibodies (MAbs) directed against bovine adenovirus (BAV) 2 subtype B hexon were studied with 12 different hexon types of human adenoviruses (AV) belonging to 5 different subgenera using indirect ELISA, passive hemagglutination (HA), and gel diffusion assays. Two hexon types of animal origin (BAV3 and SAV16) were investigated, too. The reactivity of the MAb IV.F3 was the broadest, i.e. in ELISA and HA experiments it reacted with all hexon types studied. Based on these results as well as on the results of gel diffusion assays, this MAb should recognize the genus specific epitope of adenovirus hexons. Three MAbs (CA12, III.B11, and A12) could recognize different epitopes showing intersubgenus or intertype specificities. In spite of the fact, that all the eight MAbs proved to be bound by the hexon of ORT/111 (BAV2 subtype B) blotted onto nitrocellulose filter, four of the eight MAbs (BB7, BH5, II.A9, and IV.F5) failed to react with any human, and animal hexon types used in the present experiments. The results suggest that a gradient of antigenic relationship may exist between BAV2 hexon and the hexons of human serotypes.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>2455494</pmid><doi>10.1007/BF01310903</doi><tpages>7</tpages></addata></record> |
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| ispartof | Archives of virology, 1988-01, Vol.100 (1/2), p.9-15 |
| issn | 0304-8608 1432-8798 |
| language | eng |
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| subjects | Adenoviridae Adenoviridae - classification Adenoviridae - immunology Adenoviruses, Human - classification Adenoviruses, Human - immunology Animals Antibodies, Monoclonal antigens Antigens, Viral - analysis Biological and medical sciences bovine adenovirus Capsid - immunology Enzyme-Linked Immunosorbent Assay Epitopes - analysis Fundamental and applied biological sciences. Psychology genetic variation Hemagglutination Tests Humans Immunodiffusion Microbiology monoclonal antibodies Morphology, structure, chemical composition, physicochemical properties Virology |
| title | Antigenic relationship between human and animal adenovirus hexons determined by means of monoclonal antibodies directed against bovine adenovirus type 2 hexon |
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