Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine

We describe mutations in the hepatitis B virus (HBV) polymerase gene in viruses which reactivated in two patients during therapy with ‐2′‐deoxy‐ 3′‐thiacytidine, or lamivudine (3TC), and following orthotopic liver transplantation for chronic hepatitis B. Virus resistance to 3TC is associated with mu...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 1996-09, Vol.24 (3), p.711-713
Hauptverfasser:	Ling, R, Mutimer, D, Ahmed, M, Boxall, E H, Elias, E, Dusheiko, G M, Harrison, T J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV Amino Acid Sequence Antiviral Agents - therapeutic use Base Sequence Biological and medical sciences DNA-Directed DNA Polymerase - genetics Female Hepatitis B virus - enzymology Human viral diseases Humans Infectious diseases Lamivudine - therapeutic use Liver Transplantation Male Medical sciences Middle Aged Molecular Sequence Data Mutation Oligonucleotide Probes - genetics Viral diseases Viral hepatitis
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