Influence of Elsamicin A on the Activity of Mammalian Topoisomerase I

The strong effect of elsamicin A on the mobility of DNA in agarose gels has been characterized. This antibiotic forms tight complexes that are resistant to an electrophoretic field, though they are not covalent and can be removed by phenol or 1-butanol extraction. In the presence of mammalian topois...

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Veröffentlicht in:	Biochemistry (Easton) 1996-08, Vol.35 (34), p.11177-11182
Hauptverfasser:	Rodríguez-Campos, Antonio, Azorín, Fernando, Portugal, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Animals Anti-Bacterial Agents - pharmacology Antibiotics, Antineoplastic - pharmacology DNA Helicases - metabolism DNA Topoisomerases, Type I - metabolism DNA, Superhelical - chemistry DNA, Superhelical - drug effects DNA, Superhelical - metabolism Electrophoresis, Agar Gel Enzyme Inhibitors - pharmacology Intercalating Agents - metabolism Intercalating Agents - pharmacology Kinetics Mammals - metabolism Nucleic Acid Conformation Phenol Phenols - pharmacology Topoisomerase I Inhibitors
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