Role of estrogen and prostaglandin F2 alpha in premature luteal regression in monovulatory and superovulated red deer (Cervus elaphus)
The superovulation of red deer hinds with eCG is commonly associated with premature luteal regression. This study was an investigation of the endocrine mechanisms regulating luteal function after superovulation. Four groups of hinds (n = 7-8 per group) were treated with progesterone-impregnated intr...
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| Veröffentlicht in: | Biology of reproduction 1996-02, Vol.54 (2), p.347-354 |
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| container_title | Biology of reproduction |
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| creator | BAINBRIDGE, D. R. J HUNTER, M. G CHAPPLE, D. G FLINT, A. P. F JABBOUR, H. N |
| description | The superovulation of red deer hinds with eCG is commonly associated with premature luteal regression. This study was an investigation
of the endocrine mechanisms regulating luteal function after superovulation. Four groups of hinds (n = 7-8 per group) were
treated with progesterone-impregnated intravaginal controlled internal drug-releasing (CIDR) devices for 12 days to synchronize
estrus (CIDR device withdrawal = Day 0). Group 1 served as controls; group 2 received an i.m. injection of 0.25 mg estradiol
benzoate (EDB) at 72, 84, 96, and 108 h after removal of the device; group 3 received an i.m. injection of 1200 IU eCG at
-72 h; group 4 received both EDB and eCG treatments. Oxytocin-induced prostaglandin F2 alpha (PGF2 alpha) release was assessed
on Day 4 by oxytocin challenge. Ovarian response was determined by laparoscopy on Day 14. Plasma steroid profiles were determined
from thrice-weekly plasma samples collected from Day -13 to Day 35 (progesterone) and Days 0 to 14 (estradiol). EDB increased
the incidence of premature luteal regression in monovulatory and eCG-treated animals (p < 0.05) and reduced the number of
CL (p < 0.05) in eCG-treated animals. EDB and eCG each elevated plasma concentrations of estradiol and increased the incidence
of significant oxytocin-induced PGF2 alpha release. These results support the hypothesis that eCG causes premature luteal
regression by inducing prolonged estrogen secretion that sensitizes the endometrium to oxytocin, thereby eliciting PGF2 alpha
release during the early luteal phase. |
| doi_str_mv | 10.1095/biolreprod54.2.347 |
| format | Article |
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of the endocrine mechanisms regulating luteal function after superovulation. Four groups of hinds (n = 7-8 per group) were
treated with progesterone-impregnated intravaginal controlled internal drug-releasing (CIDR) devices for 12 days to synchronize
estrus (CIDR device withdrawal = Day 0). Group 1 served as controls; group 2 received an i.m. injection of 0.25 mg estradiol
benzoate (EDB) at 72, 84, 96, and 108 h after removal of the device; group 3 received an i.m. injection of 1200 IU eCG at
-72 h; group 4 received both EDB and eCG treatments. Oxytocin-induced prostaglandin F2 alpha (PGF2 alpha) release was assessed
on Day 4 by oxytocin challenge. Ovarian response was determined by laparoscopy on Day 14. Plasma steroid profiles were determined
from thrice-weekly plasma samples collected from Day -13 to Day 35 (progesterone) and Days 0 to 14 (estradiol). EDB increased
the incidence of premature luteal regression in monovulatory and eCG-treated animals (p < 0.05) and reduced the number of
CL (p < 0.05) in eCG-treated animals. EDB and eCG each elevated plasma concentrations of estradiol and increased the incidence
of significant oxytocin-induced PGF2 alpha release. These results support the hypothesis that eCG causes premature luteal
regression by inducing prolonged estrogen secretion that sensitizes the endometrium to oxytocin, thereby eliciting PGF2 alpha
release during the early luteal phase.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod54.2.347</identifier><identifier>PMID: 8788185</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Animals ; Biological and medical sciences ; Chorionic Gonadotropin - pharmacology ; Deer - physiology ; Dinoprost - metabolism ; Dinoprost - physiology ; Estradiol - blood ; Estradiol - pharmacology ; Estrogens - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Kinetics ; Luteolysis - physiology ; Mammalian reproduction. General aspects ; Ovulation ; Oxytocin - pharmacology ; Progesterone - blood ; Superovulation ; Vertebrates: reproduction</subject><ispartof>Biology of reproduction, 1996-02, Vol.54 (2), p.347-354</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2985676$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8788185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BAINBRIDGE, D. R. J</creatorcontrib><creatorcontrib>HUNTER, M. G</creatorcontrib><creatorcontrib>CHAPPLE, D. G</creatorcontrib><creatorcontrib>FLINT, A. P. F</creatorcontrib><creatorcontrib>JABBOUR, H. N</creatorcontrib><title>Role of estrogen and prostaglandin F2 alpha in premature luteal regression in monovulatory and superovulated red deer (Cervus elaphus)</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>The superovulation of red deer hinds with eCG is commonly associated with premature luteal regression. This study was an investigation
of the endocrine mechanisms regulating luteal function after superovulation. Four groups of hinds (n = 7-8 per group) were
treated with progesterone-impregnated intravaginal controlled internal drug-releasing (CIDR) devices for 12 days to synchronize
estrus (CIDR device withdrawal = Day 0). Group 1 served as controls; group 2 received an i.m. injection of 0.25 mg estradiol
benzoate (EDB) at 72, 84, 96, and 108 h after removal of the device; group 3 received an i.m. injection of 1200 IU eCG at
-72 h; group 4 received both EDB and eCG treatments. Oxytocin-induced prostaglandin F2 alpha (PGF2 alpha) release was assessed
on Day 4 by oxytocin challenge. Ovarian response was determined by laparoscopy on Day 14. Plasma steroid profiles were determined
from thrice-weekly plasma samples collected from Day -13 to Day 35 (progesterone) and Days 0 to 14 (estradiol). EDB increased
the incidence of premature luteal regression in monovulatory and eCG-treated animals (p < 0.05) and reduced the number of
CL (p < 0.05) in eCG-treated animals. EDB and eCG each elevated plasma concentrations of estradiol and increased the incidence
of significant oxytocin-induced PGF2 alpha release. These results support the hypothesis that eCG causes premature luteal
regression by inducing prolonged estrogen secretion that sensitizes the endometrium to oxytocin, thereby eliciting PGF2 alpha
release during the early luteal phase.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chorionic Gonadotropin - pharmacology</subject><subject>Deer - physiology</subject><subject>Dinoprost - metabolism</subject><subject>Dinoprost - physiology</subject><subject>Estradiol - blood</subject><subject>Estradiol - pharmacology</subject><subject>Estrogens - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kinetics</subject><subject>Luteolysis - physiology</subject><subject>Mammalian reproduction. General aspects</subject><subject>Ovulation</subject><subject>Oxytocin - pharmacology</subject><subject>Progesterone - blood</subject><subject>Superovulation</subject><subject>Vertebrates: reproduction</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kd1q3DAQhUVoSLdJX6BQ0EUbmgtv9WPJ8mVYkrYQKJT02oyt8dpFtlzJypIX6HNX6S69mp_zceDMEPKOsy1ntfrcjt4FXIK3qtyKrSyrM7LhStRFJbR5RTaMMV1IqeVr8ibGX4zxUgp5QS5MZQw3akP-_PAOqe8pxjX4Pc4UZkuzZVxh73I_zvReUHDLADT3S8AJ1hSQurQiOBpwHzDG0c8v8uRn_5QcrD48_3OKacFwXKHNsKUWMdBPOwxPKVJ0sAwp3lyR8x5cxLenekl-3t897r4WD9-_fNvdPhQDN2wtlEFtO9aXSigAVXVgQHMh-jwKUcoWVdnVveGWIwPJGOqua7WtAbAVkslLcn30zQl_p5y5mcbYoctJ0afYVEbUXIo6g-9PYGontM0SxgnCc3M6XNY_nHSIHbg-wNyN8T8maqN0pTP28YgN4344jAGbOIFz2VQ2h8NBlY1o8tvkX_RgjsU</recordid><startdate>199602</startdate><enddate>199602</enddate><creator>BAINBRIDGE, D. R. J</creator><creator>HUNTER, M. G</creator><creator>CHAPPLE, D. G</creator><creator>FLINT, A. P. F</creator><creator>JABBOUR, H. N</creator><general>Society for the Study of Reproduction</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199602</creationdate><title>Role of estrogen and prostaglandin F2 alpha in premature luteal regression in monovulatory and superovulated red deer (Cervus elaphus)</title><author>BAINBRIDGE, D. R. J ; HUNTER, M. G ; CHAPPLE, D. G ; FLINT, A. P. F ; JABBOUR, H. N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h180t-58e6dc0f4525aa57ca8a6122f25a2243be54c9f81d1e0a300e6ccb6d9aaeb2303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chorionic Gonadotropin - pharmacology</topic><topic>Deer - physiology</topic><topic>Dinoprost - metabolism</topic><topic>Dinoprost - physiology</topic><topic>Estradiol - blood</topic><topic>Estradiol - pharmacology</topic><topic>Estrogens - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Kinetics</topic><topic>Luteolysis - physiology</topic><topic>Mammalian reproduction. General aspects</topic><topic>Ovulation</topic><topic>Oxytocin - pharmacology</topic><topic>Progesterone - blood</topic><topic>Superovulation</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BAINBRIDGE, D. R. J</creatorcontrib><creatorcontrib>HUNTER, M. G</creatorcontrib><creatorcontrib>CHAPPLE, D. G</creatorcontrib><creatorcontrib>FLINT, A. P. F</creatorcontrib><creatorcontrib>JABBOUR, H. N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BAINBRIDGE, D. R. J</au><au>HUNTER, M. G</au><au>CHAPPLE, D. G</au><au>FLINT, A. P. F</au><au>JABBOUR, H. N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of estrogen and prostaglandin F2 alpha in premature luteal regression in monovulatory and superovulated red deer (Cervus elaphus)</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>1996-02</date><risdate>1996</risdate><volume>54</volume><issue>2</issue><spage>347</spage><epage>354</epage><pages>347-354</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>The superovulation of red deer hinds with eCG is commonly associated with premature luteal regression. This study was an investigation
of the endocrine mechanisms regulating luteal function after superovulation. Four groups of hinds (n = 7-8 per group) were
treated with progesterone-impregnated intravaginal controlled internal drug-releasing (CIDR) devices for 12 days to synchronize
estrus (CIDR device withdrawal = Day 0). Group 1 served as controls; group 2 received an i.m. injection of 0.25 mg estradiol
benzoate (EDB) at 72, 84, 96, and 108 h after removal of the device; group 3 received an i.m. injection of 1200 IU eCG at
-72 h; group 4 received both EDB and eCG treatments. Oxytocin-induced prostaglandin F2 alpha (PGF2 alpha) release was assessed
on Day 4 by oxytocin challenge. Ovarian response was determined by laparoscopy on Day 14. Plasma steroid profiles were determined
from thrice-weekly plasma samples collected from Day -13 to Day 35 (progesterone) and Days 0 to 14 (estradiol). EDB increased
the incidence of premature luteal regression in monovulatory and eCG-treated animals (p < 0.05) and reduced the number of
CL (p < 0.05) in eCG-treated animals. EDB and eCG each elevated plasma concentrations of estradiol and increased the incidence
of significant oxytocin-induced PGF2 alpha release. These results support the hypothesis that eCG causes premature luteal
regression by inducing prolonged estrogen secretion that sensitizes the endometrium to oxytocin, thereby eliciting PGF2 alpha
release during the early luteal phase.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>8788185</pmid><doi>10.1095/biolreprod54.2.347</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biology of reproduction, 1996-02, Vol.54 (2), p.347-354 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals Biological and medical sciences Chorionic Gonadotropin - pharmacology Deer - physiology Dinoprost - metabolism Dinoprost - physiology Estradiol - blood Estradiol - pharmacology Estrogens - physiology Female Fundamental and applied biological sciences. Psychology Kinetics Luteolysis - physiology Mammalian reproduction. General aspects Ovulation Oxytocin - pharmacology Progesterone - blood Superovulation Vertebrates: reproduction |
| title | Role of estrogen and prostaglandin F2 alpha in premature luteal regression in monovulatory and superovulated red deer (Cervus elaphus) |
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