Expression and activity of low Km, cGMP-inhibited cAMP phosphodiesterase in cardiac and skeletal muscle

The expression and activity of low Km, cGMP-inhibited cAMP phosphodiesterase (PDE3)4 were examined in rabbit and canine cardiac and skeletal muscle. In cardiac muscle, a cDNA probe whose sequence encompasses the catalytic domain of human myocardial PDE3 (PDE3A) hybridized predominantly with a 7.2-7....

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Veröffentlicht in:	Biochemical and biophysical research communications 1996-08, Vol.225 (3), p.1058-1062
Hauptverfasser:	Movsesian, M A, Komas, N, Krall, J, Manganiello, V C
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - genetics 3',5'-Cyclic-AMP Phosphodiesterases - metabolism Animals Cyclic Nucleotide Phosphodiesterases, Type 3 Cytosol - enzymology Dogs Gene Expression Humans In Vitro Techniques Kinetics Microsomes - enzymology Muscle, Skeletal - enzymology Myocardium - enzymology Rabbits RNA, Messenger - genetics RNA, Messenger - metabolism
Online-Zugang:	Volltext
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