Plasma met-enkephalin levels in diabetic patients: Influence of autonomic neuropathy
The presence of opioid peptides within pancreatic islets in several animal species and in humans suggests that these peptides could play a role in pancreatic endocrine secretion, influencing glucose metabolism. We measured plasma met-enkephalin (met-Enk) levels in eight neuropathic (four with insuli...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1996-09, Vol.45 (9), p.1065-1068 |
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| container_title | Metabolism, clinical and experimental |
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| creator | Fallucca, F. Tonnarini, G. Di Biase, N. D'Alessandro, M. Negri, M. |
| description | The presence of opioid peptides within pancreatic islets in several animal species and in humans suggests that these peptides could play a role in pancreatic endocrine secretion, influencing glucose metabolism. We measured plasma met-enkephalin (met-Enk) levels in eight neuropathic (four with insulin-dependent diabetes mellitus [IDDM] and four with non—insulin-dependent diabetes mellitus [NIDDM]) and eight nonneuropathic (four IDDM and four NIDDM) diabetic patients to study met-Enk secretion in diabetic patients with asymptomatic autonomic neuropathy. Plasma met-Enk levels were significantly lower in neuropathic compared with nonneuropathic patients both in the IDDM group (28.7 ± 4.8
v 61.6 ± 4.1 pg/mL,
P < .0025) and in the NIDDM group (26.5 ± 3.6
v 44.3 ± 4.6 pg/mL,
P < .0125). This study suggests that the presence of neuropathy in diabetic patients, even if asymptomatic, is associated with a significant decrease of plasma met-Enk levels, thus contributing to a worsening of metabolic control under stress conditions. |
| doi_str_mv | 10.1016/S0026-0495(96)90004-9 |
| format | Article |
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v 61.6 ± 4.1 pg/mL,
P < .0025) and in the NIDDM group (26.5 ± 3.6
v 44.3 ± 4.6 pg/mL,
P < .0125). This study suggests that the presence of neuropathy in diabetic patients, even if asymptomatic, is associated with a significant decrease of plasma met-Enk levels, thus contributing to a worsening of metabolic control under stress conditions.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/S0026-0495(96)90004-9</identifier><identifier>PMID: 8781292</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 2 - blood ; Diabetes. Impaired glucose tolerance ; Diabetic Neuropathies - blood ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Enkephalin, Methionine - blood ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Humans ; Male ; Medical sciences ; Middle Aged</subject><ispartof>Metabolism, clinical and experimental, 1996-09, Vol.45 (9), p.1065-1068</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-89105026ecc0974361e86832078c5e433c0f572b928cfe8aaf9dd94e610197de3</citedby><cites>FETCH-LOGICAL-c389t-89105026ecc0974361e86832078c5e433c0f572b928cfe8aaf9dd94e610197de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026049596900049$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27902,27903,65308</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3205961$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8781292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fallucca, F.</creatorcontrib><creatorcontrib>Tonnarini, G.</creatorcontrib><creatorcontrib>Di Biase, N.</creatorcontrib><creatorcontrib>D'Alessandro, M.</creatorcontrib><creatorcontrib>Negri, M.</creatorcontrib><title>Plasma met-enkephalin levels in diabetic patients: Influence of autonomic neuropathy</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>The presence of opioid peptides within pancreatic islets in several animal species and in humans suggests that these peptides could play a role in pancreatic endocrine secretion, influencing glucose metabolism. We measured plasma met-enkephalin (met-Enk) levels in eight neuropathic (four with insulin-dependent diabetes mellitus [IDDM] and four with non—insulin-dependent diabetes mellitus [NIDDM]) and eight nonneuropathic (four IDDM and four NIDDM) diabetic patients to study met-Enk secretion in diabetic patients with asymptomatic autonomic neuropathy. Plasma met-Enk levels were significantly lower in neuropathic compared with nonneuropathic patients both in the IDDM group (28.7 ± 4.8
v 61.6 ± 4.1 pg/mL,
P < .0025) and in the NIDDM group (26.5 ± 3.6
v 44.3 ± 4.6 pg/mL,
P < .0125). This study suggests that the presence of neuropathy in diabetic patients, even if asymptomatic, is associated with a significant decrease of plasma met-Enk levels, thus contributing to a worsening of metabolic control under stress conditions.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Neuropathies - blood</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Enkephalin, Methionine - blood</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMo6_r4CUIPInqoJn2kGS8iiy9YUHA9h2w6xWiarkkr7L83-2CvnmZgvnl9hJwxes0o4zfvlGY8pQWUl8CvgFJapLBHxqzMs1RwSvfJeIcckqMQviJTVYKPyEhUgmWQjcnszarQqqTFPkX3jYtPZY1LLP6iDUnMaqPm2BudLFRv0PXhNnlxjR3QaUy6JlFD37mujYDDwXeR-lyekING2YCn23hMPh4fZpPndPr69DK5n6Y6F9CnAhgt44WoNYWqyDlDwUWe0UroEos817Qpq2wOmdANCqUaqGsokMf_oaoxPyYXm7kL3_0MGHrZmqDRWuWwG4KsRAa0hCKC5QbUvgvBYyMX3rTKLyWjcmVTrm3KlSoJXK5tSoh9Z9sFw7zFete11Rfr59u6ClrZxiunTdhh8ZUSOIvY3QaLTvHXoJdBm5XA2njUvaw7888hf1JykNc</recordid><startdate>19960901</startdate><enddate>19960901</enddate><creator>Fallucca, F.</creator><creator>Tonnarini, G.</creator><creator>Di Biase, N.</creator><creator>D'Alessandro, M.</creator><creator>Negri, M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960901</creationdate><title>Plasma met-enkephalin levels in diabetic patients: Influence of autonomic neuropathy</title><author>Fallucca, F. ; Tonnarini, G. ; Di Biase, N. ; D'Alessandro, M. ; Negri, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-89105026ecc0974361e86832078c5e433c0f572b928cfe8aaf9dd94e610197de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Neuropathies - blood</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Enkephalin, Methionine - blood</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fallucca, F.</creatorcontrib><creatorcontrib>Tonnarini, G.</creatorcontrib><creatorcontrib>Di Biase, N.</creatorcontrib><creatorcontrib>D'Alessandro, M.</creatorcontrib><creatorcontrib>Negri, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fallucca, F.</au><au>Tonnarini, G.</au><au>Di Biase, N.</au><au>D'Alessandro, M.</au><au>Negri, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma met-enkephalin levels in diabetic patients: Influence of autonomic neuropathy</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1996-09-01</date><risdate>1996</risdate><volume>45</volume><issue>9</issue><spage>1065</spage><epage>1068</epage><pages>1065-1068</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>The presence of opioid peptides within pancreatic islets in several animal species and in humans suggests that these peptides could play a role in pancreatic endocrine secretion, influencing glucose metabolism. We measured plasma met-enkephalin (met-Enk) levels in eight neuropathic (four with insulin-dependent diabetes mellitus [IDDM] and four with non—insulin-dependent diabetes mellitus [NIDDM]) and eight nonneuropathic (four IDDM and four NIDDM) diabetic patients to study met-Enk secretion in diabetic patients with asymptomatic autonomic neuropathy. Plasma met-Enk levels were significantly lower in neuropathic compared with nonneuropathic patients both in the IDDM group (28.7 ± 4.8
v 61.6 ± 4.1 pg/mL,
P < .0025) and in the NIDDM group (26.5 ± 3.6
v 44.3 ± 4.6 pg/mL,
P < .0125). This study suggests that the presence of neuropathy in diabetic patients, even if asymptomatic, is associated with a significant decrease of plasma met-Enk levels, thus contributing to a worsening of metabolic control under stress conditions.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8781292</pmid><doi>10.1016/S0026-0495(96)90004-9</doi><tpages>4</tpages></addata></record> |
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| ispartof | Metabolism, clinical and experimental, 1996-09, Vol.45 (9), p.1065-1068 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Biological and medical sciences Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 2 - blood Diabetes. Impaired glucose tolerance Diabetic Neuropathies - blood Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enkephalin, Methionine - blood Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Humans Male Medical sciences Middle Aged |
| title | Plasma met-enkephalin levels in diabetic patients: Influence of autonomic neuropathy |
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