RNA Tertiary Structure Mediation by Adenosine Platforms
The crystal structure of a group I intron domain reveals an unexpected motif that mediates both intra- and intermolecular interactions. At three separate locations in the 160-nucleotide domain, adjacent adenosines in the sequence lie side-by-side and form a pseudo-base pair within a helix. This aden...
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Veröffentlicht in: | Science (American Association for the Advancement of Science) 1996-09, Vol.273 (5282), p.1696-1699 |
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container_title | Science (American Association for the Advancement of Science) |
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creator | Cate, Jamie H. Gooding, Anne R. Podell, Elaine Zhou, Kaihong Golden, Barbara L. Szewczak, Alexander A. Kundrot, Craig E. Cech, Thomas R. Doudna, Jennifer A. |
description | The crystal structure of a group I intron domain reveals an unexpected motif that mediates both intra- and intermolecular interactions. At three separate locations in the 160-nucleotide domain, adjacent adenosines in the sequence lie side-by-side and form a pseudo-base pair within a helix. This adenosine platform opens the minor groove for base stacking or base pairing with nucleotides from a noncontiguous RNA strand. The platform motif has a distinctive chemical modification signature that may enable its detection in other structured RNAs. The ability of this motif to facilitate higher order folding provides one explanation for the abundance of adenosine residues in internal loops of many RNAs. |
doi_str_mv | 10.1126/science.273.5282.1696 |
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At three separate locations in the 160-nucleotide domain, adjacent adenosines in the sequence lie side-by-side and form a pseudo-base pair within a helix. This adenosine platform opens the minor groove for base stacking or base pairing with nucleotides from a noncontiguous RNA strand. The platform motif has a distinctive chemical modification signature that may enable its detection in other structured RNAs. The ability of this motif to facilitate higher order folding provides one explanation for the abundance of adenosine residues in internal loops of many RNAs.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.273.5282.1696</identifier><identifier>PMID: 8781229</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Adenosine ; Adenosine - chemistry ; Analytical, structural and metabolic biochemistry ; Animals ; Base Composition ; Biochemistry ; Biological and medical sciences ; Catalytic RNA ; Crystal structure ; Crystals ; Fundamental and applied biological sciences. Psychology ; Hydrogen Bonding ; Introns ; Literary Devices ; Methylation ; Models, Molecular ; Molecular biology ; Molecules ; Nucleic Acid Conformation ; Nucleic acids ; Nucleotides ; Receptors ; Ribonucleic acid ; RNA ; RNA, Catalytic - chemistry ; RNA, Protozoan - chemistry ; Rna, ribonucleoproteins ; Sulfates ; Tetrahymena thermophila - genetics</subject><ispartof>Science (American Association for the Advancement of Science), 1996-09, Vol.273 (5282), p.1696-1699</ispartof><rights>Copyright 1996 American Association for the Advancement of Science</rights><rights>1996 INIST-CNRS</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Sep 20, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c785t-412166d5be0121e05e662cf01a0390198b7f2793c0eda2a75beeb8f45edfa8953</citedby><cites>FETCH-LOGICAL-c785t-412166d5be0121e05e662cf01a0390198b7f2793c0eda2a75beeb8f45edfa8953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2891997$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2891997$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2882,2883,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3221489$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8781229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cate, Jamie H.</creatorcontrib><creatorcontrib>Gooding, Anne R.</creatorcontrib><creatorcontrib>Podell, Elaine</creatorcontrib><creatorcontrib>Zhou, Kaihong</creatorcontrib><creatorcontrib>Golden, Barbara L.</creatorcontrib><creatorcontrib>Szewczak, Alexander A.</creatorcontrib><creatorcontrib>Kundrot, Craig E.</creatorcontrib><creatorcontrib>Cech, Thomas R.</creatorcontrib><creatorcontrib>Doudna, Jennifer A.</creatorcontrib><title>RNA Tertiary Structure Mediation by Adenosine Platforms</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The crystal structure of a group I intron domain reveals an unexpected motif that mediates both intra- and intermolecular interactions. At three separate locations in the 160-nucleotide domain, adjacent adenosines in the sequence lie side-by-side and form a pseudo-base pair within a helix. This adenosine platform opens the minor groove for base stacking or base pairing with nucleotides from a noncontiguous RNA strand. The platform motif has a distinctive chemical modification signature that may enable its detection in other structured RNAs. The ability of this motif to facilitate higher order folding provides one explanation for the abundance of adenosine residues in internal loops of many RNAs.</description><subject>Adenosine</subject><subject>Adenosine - chemistry</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Base Composition</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Catalytic RNA</subject><subject>Crystal structure</subject><subject>Crystals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydrogen Bonding</subject><subject>Introns</subject><subject>Literary Devices</subject><subject>Methylation</subject><subject>Models, Molecular</subject><subject>Molecular biology</subject><subject>Molecules</subject><subject>Nucleic Acid Conformation</subject><subject>Nucleic acids</subject><subject>Nucleotides</subject><subject>Receptors</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Catalytic - chemistry</subject><subject>RNA, Protozoan - chemistry</subject><subject>Rna, ribonucleoproteins</subject><subject>Sulfates</subject><subject>Tetrahymena thermophila - genetics</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0l2L00AUgOEgyrqu_gMXgoh6sanzkfm6rEXrQt2Ku3o7TCcnZUqa2Z2ZgPvvndJSqBQtuUjIeeZAyFsUlxiNMCb8Y7QOegsjIuiIEUlGmCv-pDjHSLFKEUSfFucIUV5JJNjz4kWMK4TyTNGz4kwKiQlR54X4cTMu7yAkZ8JjeZvCYNMQoPwGjTPJ-b5cPJbjBnofXQ_l986k1od1fFk8a00X4dXuflH8_PL5bvK1ms2n15PxrLJCslTVmGDOG7YAlJ8AMeCc2BZhg6hCWMmFaIlQ1CJoDDEiQ1jItmbQtEYqRi-Kd9u998E_DBCTXrtooetMD36IWkgiFZc4w_f_hjWtCSGY_nclZpwKTlSGb_6CKz-EPn-uznsYk4yijK62aGk60K5vfQrGLqGHYDrfQ-vy6zGWgqKak8yrIzxfDaydPeY_HPhMEvxOSzPEqK9vb06m818n00_TU6mczg7o1TFqfdfBEnTuYjI_4GzLbfAxBmj1fXDrnKHGSG8S17vEdU5cbxLXm8TzucvdbxkWa2j2p3ZN5_nb3dxEa7o2mN66uGc0R1DLDXu9ZauYfNiPc05YKUH_APr5B60</recordid><startdate>19960920</startdate><enddate>19960920</enddate><creator>Cate, Jamie H.</creator><creator>Gooding, Anne R.</creator><creator>Podell, Elaine</creator><creator>Zhou, Kaihong</creator><creator>Golden, Barbara L.</creator><creator>Szewczak, Alexander A.</creator><creator>Kundrot, Craig E.</creator><creator>Cech, Thomas R.</creator><creator>Doudna, Jennifer A.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19960920</creationdate><title>RNA Tertiary Structure Mediation by Adenosine Platforms</title><author>Cate, Jamie H. ; Gooding, Anne R. ; Podell, Elaine ; Zhou, Kaihong ; Golden, Barbara L. ; Szewczak, Alexander A. ; Kundrot, Craig E. ; Cech, Thomas R. ; Doudna, Jennifer A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c785t-412166d5be0121e05e662cf01a0390198b7f2793c0eda2a75beeb8f45edfa8953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adenosine</topic><topic>Adenosine - chemistry</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Base Composition</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Catalytic RNA</topic><topic>Crystal structure</topic><topic>Crystals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hydrogen Bonding</topic><topic>Introns</topic><topic>Literary Devices</topic><topic>Methylation</topic><topic>Models, Molecular</topic><topic>Molecular biology</topic><topic>Molecules</topic><topic>Nucleic Acid Conformation</topic><topic>Nucleic acids</topic><topic>Nucleotides</topic><topic>Receptors</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Catalytic - chemistry</topic><topic>RNA, Protozoan - chemistry</topic><topic>Rna, ribonucleoproteins</topic><topic>Sulfates</topic><topic>Tetrahymena thermophila - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cate, Jamie H.</creatorcontrib><creatorcontrib>Gooding, Anne R.</creatorcontrib><creatorcontrib>Podell, Elaine</creatorcontrib><creatorcontrib>Zhou, Kaihong</creatorcontrib><creatorcontrib>Golden, Barbara L.</creatorcontrib><creatorcontrib>Szewczak, Alexander A.</creatorcontrib><creatorcontrib>Kundrot, Craig 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At three separate locations in the 160-nucleotide domain, adjacent adenosines in the sequence lie side-by-side and form a pseudo-base pair within a helix. This adenosine platform opens the minor groove for base stacking or base pairing with nucleotides from a noncontiguous RNA strand. The platform motif has a distinctive chemical modification signature that may enable its detection in other structured RNAs. The ability of this motif to facilitate higher order folding provides one explanation for the abundance of adenosine residues in internal loops of many RNAs.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8781229</pmid><doi>10.1126/science.273.5282.1696</doi><tpages>4</tpages></addata></record> |
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subjects | Adenosine Adenosine - chemistry Analytical, structural and metabolic biochemistry Animals Base Composition Biochemistry Biological and medical sciences Catalytic RNA Crystal structure Crystals Fundamental and applied biological sciences. Psychology Hydrogen Bonding Introns Literary Devices Methylation Models, Molecular Molecular biology Molecules Nucleic Acid Conformation Nucleic acids Nucleotides Receptors Ribonucleic acid RNA RNA, Catalytic - chemistry RNA, Protozoan - chemistry Rna, ribonucleoproteins Sulfates Tetrahymena thermophila - genetics |
title | RNA Tertiary Structure Mediation by Adenosine Platforms |
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