RNA Tertiary Structure Mediation by Adenosine Platforms

The crystal structure of a group I intron domain reveals an unexpected motif that mediates both intra- and intermolecular interactions. At three separate locations in the 160-nucleotide domain, adjacent adenosines in the sequence lie side-by-side and form a pseudo-base pair within a helix. This aden...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1996-09, Vol.273 (5282), p.1696-1699
Hauptverfasser: Cate, Jamie H., Gooding, Anne R., Podell, Elaine, Zhou, Kaihong, Golden, Barbara L., Szewczak, Alexander A., Kundrot, Craig E., Cech, Thomas R., Doudna, Jennifer A.
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container_end_page 1699
container_issue 5282
container_start_page 1696
container_title Science (American Association for the Advancement of Science)
container_volume 273
creator Cate, Jamie H.
Gooding, Anne R.
Podell, Elaine
Zhou, Kaihong
Golden, Barbara L.
Szewczak, Alexander A.
Kundrot, Craig E.
Cech, Thomas R.
Doudna, Jennifer A.
description The crystal structure of a group I intron domain reveals an unexpected motif that mediates both intra- and intermolecular interactions. At three separate locations in the 160-nucleotide domain, adjacent adenosines in the sequence lie side-by-side and form a pseudo-base pair within a helix. This adenosine platform opens the minor groove for base stacking or base pairing with nucleotides from a noncontiguous RNA strand. The platform motif has a distinctive chemical modification signature that may enable its detection in other structured RNAs. The ability of this motif to facilitate higher order folding provides one explanation for the abundance of adenosine residues in internal loops of many RNAs.
doi_str_mv 10.1126/science.273.5282.1696
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Psychology</subject><subject>Hydrogen Bonding</subject><subject>Introns</subject><subject>Literary Devices</subject><subject>Methylation</subject><subject>Models, Molecular</subject><subject>Molecular biology</subject><subject>Molecules</subject><subject>Nucleic Acid Conformation</subject><subject>Nucleic acids</subject><subject>Nucleotides</subject><subject>Receptors</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Catalytic - chemistry</subject><subject>RNA, Protozoan - chemistry</subject><subject>Rna, ribonucleoproteins</subject><subject>Sulfates</subject><subject>Tetrahymena thermophila - genetics</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0l2L00AUgOEgyrqu_gMXgoh6sanzkfm6rEXrQt2Ku3o7TCcnZUqa2Z2ZgPvvndJSqBQtuUjIeeZAyFsUlxiNMCb8Y7QOegsjIuiIEUlGmCv-pDjHSLFKEUSfFucIUV5JJNjz4kWMK4TyTNGz4kwKiQlR54X4cTMu7yAkZ8JjeZvCYNMQoPwGjTPJ-b5cPJbjBnofXQ_l986k1od1fFk8a00X4dXuflH8_PL5bvK1ms2n15PxrLJCslTVmGDOG7YAlJ8AMeCc2BZhg6hCWMmFaIlQ1CJoDDEiQ1jItmbQtEYqRi-Kd9u998E_DBCTXrtooetMD36IWkgiFZc4w_f_hjWtCSGY_nclZpwKTlSGb_6CKz-EPn-uznsYk4yijK62aGk60K5vfQrGLqGHYDrfQ-vy6zGWgqKak8yrIzxfDaydPeY_HPhMEvxOSzPEqK9vb06m818n00_TU6mczg7o1TFqfdfBEnTuYjI_4GzLbfAxBmj1fXDrnKHGSG8S17vEdU5cbxLXm8TzucvdbxkWa2j2p3ZN5_nb3dxEa7o2mN66uGc0R1DLDXu9ZauYfNiPc05YKUH_APr5B60</recordid><startdate>19960920</startdate><enddate>19960920</enddate><creator>Cate, Jamie H.</creator><creator>Gooding, Anne R.</creator><creator>Podell, Elaine</creator><creator>Zhou, Kaihong</creator><creator>Golden, Barbara L.</creator><creator>Szewczak, Alexander A.</creator><creator>Kundrot, Craig E.</creator><creator>Cech, Thomas R.</creator><creator>Doudna, Jennifer A.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19960920</creationdate><title>RNA Tertiary Structure Mediation by Adenosine Platforms</title><author>Cate, Jamie H. ; 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identifier ISSN: 0036-8075
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issn 0036-8075
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source American Association for the Advancement of Science; MEDLINE; JSTOR
subjects Adenosine
Adenosine - chemistry
Analytical, structural and metabolic biochemistry
Animals
Base Composition
Biochemistry
Biological and medical sciences
Catalytic RNA
Crystal structure
Crystals
Fundamental and applied biological sciences. Psychology
Hydrogen Bonding
Introns
Literary Devices
Methylation
Models, Molecular
Molecular biology
Molecules
Nucleic Acid Conformation
Nucleic acids
Nucleotides
Receptors
Ribonucleic acid
RNA
RNA, Catalytic - chemistry
RNA, Protozoan - chemistry
Rna, ribonucleoproteins
Sulfates
Tetrahymena thermophila - genetics
title RNA Tertiary Structure Mediation by Adenosine Platforms
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