Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies

A series of polycyclic aryl- and heteroarylpiperazinyl imides were prepared and tested in various receptor-binding and behavioral tests. Parameters measured included in vitro inhibition of D2 and 5-HT1A receptor binding, inhibition of apomorphine (APO) induced stereotyped and climbing behavior, and...

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Veröffentlicht in:	Journal of medicinal chemistry 1988-07, Vol.31 (7), p.1382-1392
Hauptverfasser:	Abou-Gharbia, Magid, Patel, Usha R, Webb, Michael B, Moyer, John A, Andree, Terrance H, Muth, Eric A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents Apomorphine - pharmacology Avoidance Learning - drug effects Behavior, Animal - drug effects Brain - metabolism Chemical Phenomena Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Imides - chemical synthesis Imides - metabolism Imides - pharmacology Male Organic chemistry Piperazines - chemical synthesis Piperazines - metabolism Piperazines - pharmacology Preparations and properties Rats Rats, Inbred Strains Receptors, Dopamine - metabolism Receptors, Dopamine D2 Receptors, Serotonin - metabolism Stereotyped Behavior - drug effects Structure-Activity Relationship
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