Post-translational modifications of lantibiotics
Several newly reported post-translational modification reactions are involved in lantibiotic biosynthesis. A short overview of the present knowledge on the post-translational modifications and on the enzymes involved in lantibiotic biosynthesis is given. The oxidative decarboxylation of the epidermi...
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| Veröffentlicht in: | Antonie van Leeuwenhoek 1996-02, Vol.69 (2), p.139-150 |
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| container_title | Antonie van Leeuwenhoek |
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| creator | KUPKE, T GÖTZ, F |
| description | Several newly reported post-translational modification reactions are involved in lantibiotic biosynthesis. A short overview of the present knowledge on the post-translational modifications and on the enzymes involved in lantibiotic biosynthesis is given. The oxidative decarboxylation of the epidermin precursor peptide EpiA is described in detail. The FMN-containing oxidoreductase EpiD is involved in the formation of the C-terminal S-[(Z)-2-aminovinyl]-D-cysteine residue of epidermin: under reducing conditions the side chain of the C-terminal cysteine residue of EpiA is converted to an enethiol. EpiD has no absolute substrate specificity and can be used for modification of peptides having the C-terminal consensus motif [V/I/L/(M)/F/Y/W]-[A/S/V/T/C/(I/L)]-C. |
| doi_str_mv | 10.1007/bf00399419 |
| format | Article |
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A short overview of the present knowledge on the post-translational modifications and on the enzymes involved in lantibiotic biosynthesis is given. The oxidative decarboxylation of the epidermin precursor peptide EpiA is described in detail. The FMN-containing oxidoreductase EpiD is involved in the formation of the C-terminal S-[(Z)-2-aminovinyl]-D-cysteine residue of epidermin: under reducing conditions the side chain of the C-terminal cysteine residue of EpiA is converted to an enethiol. EpiD has no absolute substrate specificity and can be used for modification of peptides having the C-terminal consensus motif [V/I/L/(M)/F/Y/W]-[A/S/V/T/C/(I/L)]-C.</description><subject>Amino Acid Sequence</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - metabolism</subject><subject>Bacteriocins</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Carboxy-Lyases</subject><subject>Decarboxylation</subject><subject>Flavoproteins - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Oxidoreductases - isolation & purification</subject><subject>Oxidoreductases - metabolism</subject><subject>Peptide Chain Termination, Translational</subject><subject>Peptides</subject><subject>Protein Processing, Post-Translational</subject><issn>0003-6072</issn><issn>1572-9699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotVYv3oUexIOwOvlOjlqsCgU96HlJ0gQiu03d7B7890a79uppeOd9GIYHoXMMNxhA3toAQLVmWB-gKeaSVFpofYimUPaVAEmO0UnOHyVqoeQETZSUXEs2RfCacl_1ndnkxvQxbUwzb9M6huh-Y56nMG_Mpo82pj66fIqOgmmyPxvnDL0vH94WT9Xq5fF5cbeqHAPVV0Rhoqhk2BBpwAemFHNceGWZAUsdpR4LZ5XghWFcBY69J-AtAxewwHSGrnZ3t136HHzu6zZm55vyi09DrqUiimOs_wWLD6mB8QJe70DXpZw7H-ptF1vTfdUY6h-P9f3yz2OBL8arg239eo-O4kp_OfYmO9OEItDFvMcoEE2koN9MbHg9</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>KUPKE, T</creator><creator>GÖTZ, F</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19960201</creationdate><title>Post-translational modifications of lantibiotics</title><author>KUPKE, T ; GÖTZ, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-281283741a27a0ef4884c56e8b4a0b3c33e16cb865741458f51ee20eb40cf1613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Amino Acid Sequence</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - metabolism</topic><topic>Bacteriocins</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Carboxy-Lyases</topic><topic>Decarboxylation</topic><topic>Flavoproteins - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Oxidoreductases - isolation & purification</topic><topic>Oxidoreductases - metabolism</topic><topic>Peptide Chain Termination, Translational</topic><topic>Peptides</topic><topic>Protein Processing, Post-Translational</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUPKE, T</creatorcontrib><creatorcontrib>GÖTZ, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Antonie van Leeuwenhoek</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUPKE, T</au><au>GÖTZ, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-translational modifications of lantibiotics</atitle><jtitle>Antonie van Leeuwenhoek</jtitle><addtitle>Antonie Van Leeuwenhoek</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>69</volume><issue>2</issue><spage>139</spage><epage>150</epage><pages>139-150</pages><issn>0003-6072</issn><eissn>1572-9699</eissn><coden>ANLEDR</coden><abstract>Several newly reported post-translational modification reactions are involved in lantibiotic biosynthesis. 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| ispartof | Antonie van Leeuwenhoek, 1996-02, Vol.69 (2), p.139-150 |
| issn | 0003-6072 1572-9699 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Amino Acid Sequence Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Bacteriocins Bacteriology Biological and medical sciences Carboxy-Lyases Decarboxylation Flavoproteins - metabolism Fundamental and applied biological sciences. Psychology Genetics Microbiology Molecular Sequence Data Oxidoreductases - isolation & purification Oxidoreductases - metabolism Peptide Chain Termination, Translational Peptides Protein Processing, Post-Translational |
| title | Post-translational modifications of lantibiotics |
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