Targeted disruption of the murine tissue factor gene results in embryonic lethality
Tissue factor (TF) is an integral membrane glycoprotein that is believed to be the physiologic initiator of the blood coagulation cascade. Disruption of the mouse tissue factor gene leads to embryonic lethality between days E9.5-E11.5 of gestation. On E9.5, TF(-/-) embryos appear indistinguishable f...
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| Veröffentlicht in: | Blood 1996-09, Vol.88 (5), p.1583-1587 |
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| container_title | Blood |
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| creator | TOOMEY, J. R KRATZER, K. E LASKY, N. M STANTON, J. J BROZE, G. J |
| description | Tissue factor (TF) is an integral membrane glycoprotein that is believed to be the physiologic initiator of the blood coagulation cascade. Disruption of the mouse tissue factor gene leads to embryonic lethality between days E9.5-E11.5 of gestation. On E9.5, TF(-/-) embryos appear indistinguishable from their TF(+/+) and TF(+/-) littermates. By E10.5, TF(-/-) embryos are severely growth retarded, appear nearly bloodless, and are in most cases dead. Initial observations suggest that TF(-/-) embryos are dying of circulatory failure. Approximately 15% of the TF(-/-) embryos survive beyond E10.5, but none complete gestation. Heterozygotes appear normal and free of bleeding complications. |
| doi_str_mv | 10.1182/blood.v88.5.1583.1583 |
| format | Article |
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Heterozygotes appear normal and free of bleeding complications.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.v88.5.1583.1583</identifier><identifier>PMID: 8781413</identifier><language>eng</language><publisher>Washington, DC: The Americain Society of Hematology</publisher><subject>Animals ; Biological and medical sciences ; Blood Coagulation - genetics ; Blood coagulation. Blood cells ; Chimera ; Embryo, Mammalian - blood supply ; Female ; Fetal Death - genetics ; Fetal Growth Retardation - genetics ; Fundamental and applied biological sciences. 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Heterozygotes appear normal and free of bleeding complications.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation - genetics</subject><subject>Blood coagulation. Blood cells</subject><subject>Chimera</subject><subject>Embryo, Mammalian - blood supply</subject><subject>Female</subject><subject>Fetal Death - genetics</subject><subject>Fetal Growth Retardation - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Targeting</subject><subject>General aspects, investigation methods, hemostasis, fibrinolysis</subject><subject>Genetic Vectors - genetics</subject><subject>Gestational Age</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Molecular and cellular biology</subject><subject>Thromboplastin - deficiency</subject><subject>Thromboplastin - genetics</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFv2zAMhYViRZam_QkFdBh2c0Zask0fh2JbCxToYemugmzTqQrbyiR5QP793DTohQT43iOJT4hbhC0i5d-awftu-49oW2yxIHUqF2KNRU4ZQA6fxBoAykzXFX4WVzG-AqBWebESK6oINaq1-L2zYc-JO9m5GOZDcn6SvpfpheU4BzexTC7GmWVv2-SD3PMyChznIUXpJsljE45-cq0cOL3YwaXjtbjs7RD55tw34vnnj93dffb49Ovh7vtj1uqaUsZNpUuLutC5bZuGsEbbQMdWEzUWFIJlyqGrmVFVUJVYq7pXVJeqBlWC2oiv73sPwf-dOSYzutjyMNiJ_RxNRTkpXeFiLN6NbfAxBu7NIbjRhqNBMG8wzQmm-UNkCvPG8VSW3O35wNyM3H2kzvQW_ctZt7G1Qx_s1Lr4YVP58qYq1H-v7n7P</recordid><startdate>19960901</startdate><enddate>19960901</enddate><creator>TOOMEY, J. 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Psychology</topic><topic>Gene Targeting</topic><topic>General aspects, investigation methods, hemostasis, fibrinolysis</topic><topic>Genetic Vectors - genetics</topic><topic>Gestational Age</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Molecular and cellular biology</topic><topic>Thromboplastin - deficiency</topic><topic>Thromboplastin - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TOOMEY, J. R</creatorcontrib><creatorcontrib>KRATZER, K. E</creatorcontrib><creatorcontrib>LASKY, N. M</creatorcontrib><creatorcontrib>STANTON, J. J</creatorcontrib><creatorcontrib>BROZE, G. 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J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeted disruption of the murine tissue factor gene results in embryonic lethality</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1996-09-01</date><risdate>1996</risdate><volume>88</volume><issue>5</issue><spage>1583</spage><epage>1587</epage><pages>1583-1587</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Tissue factor (TF) is an integral membrane glycoprotein that is believed to be the physiologic initiator of the blood coagulation cascade. Disruption of the mouse tissue factor gene leads to embryonic lethality between days E9.5-E11.5 of gestation. On E9.5, TF(-/-) embryos appear indistinguishable from their TF(+/+) and TF(+/-) littermates. By E10.5, TF(-/-) embryos are severely growth retarded, appear nearly bloodless, and are in most cases dead. Initial observations suggest that TF(-/-) embryos are dying of circulatory failure. Approximately 15% of the TF(-/-) embryos survive beyond E10.5, but none complete gestation. Heterozygotes appear normal and free of bleeding complications.</abstract><cop>Washington, DC</cop><pub>The Americain Society of Hematology</pub><pmid>8781413</pmid><doi>10.1182/blood.v88.5.1583.1583</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Blood, 1996-09, Vol.88 (5), p.1583-1587 |
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| language | eng |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ）; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Blood Coagulation - genetics Blood coagulation. Blood cells Chimera Embryo, Mammalian - blood supply Female Fetal Death - genetics Fetal Growth Retardation - genetics Fundamental and applied biological sciences. Psychology Gene Targeting General aspects, investigation methods, hemostasis, fibrinolysis Genetic Vectors - genetics Gestational Age Male Mice Mice, Inbred C57BL Mice, Knockout Molecular and cellular biology Thromboplastin - deficiency Thromboplastin - genetics |
| title | Targeted disruption of the murine tissue factor gene results in embryonic lethality |
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