Prenatal and perinatal factors and cerebral palsy in very low birth weight infants
OBJECTIVE. To identify prenatal and perinatal characteristics associated with cerebral palsy (CP) in infants born weighing
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| Veröffentlicht in: | The Journal of pediatrics 1996-03, Vol.128 (3), p.407-414 |
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| container_title | The Journal of pediatrics |
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| creator | Grether, Judith K. Nelson, Karin B. Emery, E.Stanley Cummins, Susan K. |
| description | OBJECTIVE. To identify prenatal and perinatal characteristics associated with cerebral palsy (CP) in infants born weighing |
| doi_str_mv | 10.1016/S0022-3476(96)70292-5 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78282632</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347696702925</els_id><sourcerecordid>78282632</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-cbf21197f14e1bef8ad97d6c5072e203ed5968ab525ce36f8efeced1d328e7d33</originalsourceid><addsrcrecordid>eNqFkEtPGzEURq2qiAban4A0i6qCxYAf49eqQhEvCQlEYW157OviajKT2pOg_HtMMsqWlXXvd67texA6IficYCIu_mBMac0aKU61OJOYalrzL2hGsJa1UIx9RbM98g0d5fwPY6wbjA_RoZKy4YTP0NNjgt6Otqts76slpLirgnXjkPK26yBBm0pzabu8qWJfrSFtqm54q9qYxtfqDeLf17EEwfZj_o4OQgHhx3Qeo5frq-f5bX3_cHM3v7yvHVN6rF0bKCFaBtIAaSEo67X0wnEsKVDMwHMtlG055Q6YCAoCOPDEM6pAesaO0a_dvcs0_F9BHs0iZgddZ3sYVtlIRRUVjBaQ70CXhpwTBLNMcWHTxhBsPlyarUvzIcpoYbYuDS9zJ9MDq3YBfj81ySv5zym32dkuJNu7mPcYw5wR2RTs9w6DImMdIZnsIvRll5jAjcYP8ZOPvANBy5FX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78282632</pqid></control><display><type>article</type><title>Prenatal and perinatal factors and cerebral palsy in very low birth weight infants</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Grether, Judith K. ; Nelson, Karin B. ; Emery, E.Stanley ; Cummins, Susan K.</creator><creatorcontrib>Grether, Judith K. ; Nelson, Karin B. ; Emery, E.Stanley ; Cummins, Susan K.</creatorcontrib><description>OBJECTIVE. To identify prenatal and perinatal characteristics associated with cerebral palsy (CP) in infants born weighing <1500 gm (very low birth weight, VLBW).
DESIGN. All 42 VLBW singleton infants with CP born in the period from 1983 to 1985 in a defined population were compared with 75 randomly selected VLBW control infants.
RESULTS. Birth in a level I facility was associated with increased risk of CP (odds ratio [OR] 6.3, 95% confidence interval [CI] 1.8, 19), as was birth within 3 hours of the mother's first admission for delivery (OR 3.2, CI 1.4, 7.4). Delivery occurred within 3 hours of admission to a level I facility in 24% of VLBW children with CP and no control children (OR [0.5 added to each cell of 2 × 2 table] 49, CI 3.1, 204). Chorionitis was associated with increased risk in children born more than 5 hours after admission (OR 4.3, CI 1.1, 13). Chorionitis followed by neonatal seizures occurred in 14% of VLBW children with CP (in 25% with spastic diplegia) and in no control child (OR [0.5 added to each cell of 2 × 2 table] 26, CI 1.6, 116). Preeclampsia was associated with decreased risk (OR 0.08, CI 0.02, 0.67), as was use of magnesium sulfate (OR 0.14, CI 0.05, 0.51) administered for preeclampsia or preterm labor. Other risk factors for CP included gravidity greater than one (OR 3.9, CI 1.2, 11), short interbirth interval (OR 4.1, CI 1.3, 12), and vaginal bleeding on the day of admission (OR 2.9, CI 1.2, 7.4).
CONCLUSIONS. In this population-based study, almost one fourth of the CP in VLBW children occurred in infants delivered in level I facilities soon after their mothers' admissions. Another 14% was in children who had neonatal seizures after birth to women with chorionitis. No control subject experienced either of these sequences. (J P
EDIATR 1996;128:407-14)</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(96)70292-5</identifier><identifier>PMID: 8774515</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Case-Control Studies ; Cerebral Palsy - epidemiology ; Child, Preschool ; Chorioamnionitis - epidemiology ; Confidence Intervals ; Delivery, Obstetric ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Female ; Humans ; Infant, Newborn ; Infant, Very Low Birth Weight ; Intensive care medicine ; Magnesium Sulfate - therapeutic use ; Medical sciences ; Obstetric Labor, Premature - epidemiology ; Odds Ratio ; Pregnancy ; Pregnancy Complications - epidemiology ; Random Allocation ; Risk Factors ; Seizures - epidemiology ; Time Factors ; Tocolytic Agents - therapeutic use</subject><ispartof>The Journal of pediatrics, 1996-03, Vol.128 (3), p.407-414</ispartof><rights>1996 Mosby, Inc.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-cbf21197f14e1bef8ad97d6c5072e203ed5968ab525ce36f8efeced1d328e7d33</citedby><cites>FETCH-LOGICAL-c389t-cbf21197f14e1bef8ad97d6c5072e203ed5968ab525ce36f8efeced1d328e7d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(96)70292-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3053174$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8774515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grether, Judith K.</creatorcontrib><creatorcontrib>Nelson, Karin B.</creatorcontrib><creatorcontrib>Emery, E.Stanley</creatorcontrib><creatorcontrib>Cummins, Susan K.</creatorcontrib><title>Prenatal and perinatal factors and cerebral palsy in very low birth weight infants</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>OBJECTIVE. To identify prenatal and perinatal characteristics associated with cerebral palsy (CP) in infants born weighing <1500 gm (very low birth weight, VLBW).
DESIGN. All 42 VLBW singleton infants with CP born in the period from 1983 to 1985 in a defined population were compared with 75 randomly selected VLBW control infants.
RESULTS. Birth in a level I facility was associated with increased risk of CP (odds ratio [OR] 6.3, 95% confidence interval [CI] 1.8, 19), as was birth within 3 hours of the mother's first admission for delivery (OR 3.2, CI 1.4, 7.4). Delivery occurred within 3 hours of admission to a level I facility in 24% of VLBW children with CP and no control children (OR [0.5 added to each cell of 2 × 2 table] 49, CI 3.1, 204). Chorionitis was associated with increased risk in children born more than 5 hours after admission (OR 4.3, CI 1.1, 13). Chorionitis followed by neonatal seizures occurred in 14% of VLBW children with CP (in 25% with spastic diplegia) and in no control child (OR [0.5 added to each cell of 2 × 2 table] 26, CI 1.6, 116). Preeclampsia was associated with decreased risk (OR 0.08, CI 0.02, 0.67), as was use of magnesium sulfate (OR 0.14, CI 0.05, 0.51) administered for preeclampsia or preterm labor. Other risk factors for CP included gravidity greater than one (OR 3.9, CI 1.2, 11), short interbirth interval (OR 4.1, CI 1.3, 12), and vaginal bleeding on the day of admission (OR 2.9, CI 1.2, 7.4).
CONCLUSIONS. In this population-based study, almost one fourth of the CP in VLBW children occurred in infants delivered in level I facilities soon after their mothers' admissions. Another 14% was in children who had neonatal seizures after birth to women with chorionitis. No control subject experienced either of these sequences. (J P
EDIATR 1996;128:407-14)</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cerebral Palsy - epidemiology</subject><subject>Child, Preschool</subject><subject>Chorioamnionitis - epidemiology</subject><subject>Confidence Intervals</subject><subject>Delivery, Obstetric</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Very Low Birth Weight</subject><subject>Intensive care medicine</subject><subject>Magnesium Sulfate - therapeutic use</subject><subject>Medical sciences</subject><subject>Obstetric Labor, Premature - epidemiology</subject><subject>Odds Ratio</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Random Allocation</subject><subject>Risk Factors</subject><subject>Seizures - epidemiology</subject><subject>Time Factors</subject><subject>Tocolytic Agents - therapeutic use</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPGzEURq2qiAban4A0i6qCxYAf49eqQhEvCQlEYW157OviajKT2pOg_HtMMsqWlXXvd67texA6IficYCIu_mBMac0aKU61OJOYalrzL2hGsJa1UIx9RbM98g0d5fwPY6wbjA_RoZKy4YTP0NNjgt6Otqts76slpLirgnXjkPK26yBBm0pzabu8qWJfrSFtqm54q9qYxtfqDeLf17EEwfZj_o4OQgHhx3Qeo5frq-f5bX3_cHM3v7yvHVN6rF0bKCFaBtIAaSEo67X0wnEsKVDMwHMtlG055Q6YCAoCOPDEM6pAesaO0a_dvcs0_F9BHs0iZgddZ3sYVtlIRRUVjBaQ70CXhpwTBLNMcWHTxhBsPlyarUvzIcpoYbYuDS9zJ9MDq3YBfj81ySv5zym32dkuJNu7mPcYw5wR2RTs9w6DImMdIZnsIvRll5jAjcYP8ZOPvANBy5FX</recordid><startdate>19960301</startdate><enddate>19960301</enddate><creator>Grether, Judith K.</creator><creator>Nelson, Karin B.</creator><creator>Emery, E.Stanley</creator><creator>Cummins, Susan K.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960301</creationdate><title>Prenatal and perinatal factors and cerebral palsy in very low birth weight infants</title><author>Grether, Judith K. ; Nelson, Karin B. ; Emery, E.Stanley ; Cummins, Susan K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-cbf21197f14e1bef8ad97d6c5072e203ed5968ab525ce36f8efeced1d328e7d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cerebral Palsy - epidemiology</topic><topic>Child, Preschool</topic><topic>Chorioamnionitis - epidemiology</topic><topic>Confidence Intervals</topic><topic>Delivery, Obstetric</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Very Low Birth Weight</topic><topic>Intensive care medicine</topic><topic>Magnesium Sulfate - therapeutic use</topic><topic>Medical sciences</topic><topic>Obstetric Labor, Premature - epidemiology</topic><topic>Odds Ratio</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Random Allocation</topic><topic>Risk Factors</topic><topic>Seizures - epidemiology</topic><topic>Time Factors</topic><topic>Tocolytic Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grether, Judith K.</creatorcontrib><creatorcontrib>Nelson, Karin B.</creatorcontrib><creatorcontrib>Emery, E.Stanley</creatorcontrib><creatorcontrib>Cummins, Susan K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grether, Judith K.</au><au>Nelson, Karin B.</au><au>Emery, E.Stanley</au><au>Cummins, Susan K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal and perinatal factors and cerebral palsy in very low birth weight infants</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1996-03-01</date><risdate>1996</risdate><volume>128</volume><issue>3</issue><spage>407</spage><epage>414</epage><pages>407-414</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>OBJECTIVE. To identify prenatal and perinatal characteristics associated with cerebral palsy (CP) in infants born weighing <1500 gm (very low birth weight, VLBW).
DESIGN. All 42 VLBW singleton infants with CP born in the period from 1983 to 1985 in a defined population were compared with 75 randomly selected VLBW control infants.
RESULTS. Birth in a level I facility was associated with increased risk of CP (odds ratio [OR] 6.3, 95% confidence interval [CI] 1.8, 19), as was birth within 3 hours of the mother's first admission for delivery (OR 3.2, CI 1.4, 7.4). Delivery occurred within 3 hours of admission to a level I facility in 24% of VLBW children with CP and no control children (OR [0.5 added to each cell of 2 × 2 table] 49, CI 3.1, 204). Chorionitis was associated with increased risk in children born more than 5 hours after admission (OR 4.3, CI 1.1, 13). Chorionitis followed by neonatal seizures occurred in 14% of VLBW children with CP (in 25% with spastic diplegia) and in no control child (OR [0.5 added to each cell of 2 × 2 table] 26, CI 1.6, 116). Preeclampsia was associated with decreased risk (OR 0.08, CI 0.02, 0.67), as was use of magnesium sulfate (OR 0.14, CI 0.05, 0.51) administered for preeclampsia or preterm labor. Other risk factors for CP included gravidity greater than one (OR 3.9, CI 1.2, 11), short interbirth interval (OR 4.1, CI 1.3, 12), and vaginal bleeding on the day of admission (OR 2.9, CI 1.2, 7.4).
CONCLUSIONS. In this population-based study, almost one fourth of the CP in VLBW children occurred in infants delivered in level I facilities soon after their mothers' admissions. Another 14% was in children who had neonatal seizures after birth to women with chorionitis. No control subject experienced either of these sequences. (J P
EDIATR 1996;128:407-14)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>8774515</pmid><doi>10.1016/S0022-3476(96)70292-5</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Case-Control Studies Cerebral Palsy - epidemiology Child, Preschool Chorioamnionitis - epidemiology Confidence Intervals Delivery, Obstetric Emergency and intensive care: neonates and children. Prematurity. Sudden death Female Humans Infant, Newborn Infant, Very Low Birth Weight Intensive care medicine Magnesium Sulfate - therapeutic use Medical sciences Obstetric Labor, Premature - epidemiology Odds Ratio Pregnancy Pregnancy Complications - epidemiology Random Allocation Risk Factors Seizures - epidemiology Time Factors Tocolytic Agents - therapeutic use |
| title | Prenatal and perinatal factors and cerebral palsy in very low birth weight infants |
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