Long-term ototoxic effects of neomycin applied topically in the middle ear: A morphological study in the guinea pig
Neomycin was instilled daily, uni-or bilaterally, into the middle ear of guinea pigs for three months. The cochleae were examined, by light and electron microscopy, six months after the end of treatment. The organs of Corti of the treated ears were completely destroyed, and in the most advanced lesi...
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| Veröffentlicht in: | Journal of laryngology and otology 1988-04, Vol.102 (4), p.304-307 |
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| container_title | Journal of laryngology and otology |
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| creator | Morais, Darí Gonz´lez, Miguel Villar, Rosario Del Gayoso, Manuel J. |
| description | Neomycin was instilled daily, uni-or bilaterally, into the middle ear of guinea pigs for three months. The cochleae were examined, by light and electron microscopy, six months after the end of treatment. The organs of Corti of the treated ears were completely destroyed, and in the most advanced lesions, were substituted by a single layer of very thin flat cells. In the spiral ganglion only some glial cells and a few neurons could be observed. All surviving neurons were myelinated, and their ultrastructure was greatly altered, with disappeared, losing it amorphous and filamentous components. The spiral limbus and the stria vascularis were atrophic and were also covered, in the final stages, by flat elongated cells. In view of its morphological characteristics, this epithelium may arise from the displacement of the interdental cells and perhaps from the cochlear surface of Reissner's membrane. |
| doi_str_mv | 10.1017/S0022215100104815 |
| format | Article |
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The cochleae were examined, by light and electron microscopy, six months after the end of treatment. The organs of Corti of the treated ears were completely destroyed, and in the most advanced lesions, were substituted by a single layer of very thin flat cells. In the spiral ganglion only some glial cells and a few neurons could be observed. All surviving neurons were myelinated, and their ultrastructure was greatly altered, with disappeared, losing it amorphous and filamentous components. The spiral limbus and the stria vascularis were atrophic and were also covered, in the final stages, by flat elongated cells. 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Laryngol. Otol</addtitle><description>Neomycin was instilled daily, uni-or bilaterally, into the middle ear of guinea pigs for three months. The cochleae were examined, by light and electron microscopy, six months after the end of treatment. The organs of Corti of the treated ears were completely destroyed, and in the most advanced lesions, were substituted by a single layer of very thin flat cells. In the spiral ganglion only some glial cells and a few neurons could be observed. All surviving neurons were myelinated, and their ultrastructure was greatly altered, with disappeared, losing it amorphous and filamentous components. The spiral limbus and the stria vascularis were atrophic and were also covered, in the final stages, by flat elongated cells. In view of its morphological characteristics, this epithelium may arise from the displacement of the interdental cells and perhaps from the cochlear surface of Reissner's membrane.</description><subject>Administration, Topical</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cochlea - drug effects</subject><subject>Cochlea - ultrastructure</subject><subject>Drug Administration Schedule</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Ear, Middle</subject><subject>Guinea Pigs</subject><subject>Main Articles</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Neomycin - administration & dosage</subject><subject>Neomycin - adverse effects</subject><subject>Pharmacology. 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Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morais, Darí</creatorcontrib><creatorcontrib>Gonz´lez, Miguel</creatorcontrib><creatorcontrib>Villar, Rosario Del</creatorcontrib><creatorcontrib>Gayoso, Manuel J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of laryngology and otology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morais, Darí</au><au>Gonz´lez, Miguel</au><au>Villar, Rosario Del</au><au>Gayoso, Manuel J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term ototoxic effects of neomycin applied topically in the middle ear: A morphological study in the guinea pig</atitle><jtitle>Journal of laryngology and otology</jtitle><addtitle>J. Laryngol. Otol</addtitle><date>1988-04-01</date><risdate>1988</risdate><volume>102</volume><issue>4</issue><spage>304</spage><epage>307</epage><pages>304-307</pages><issn>0022-2151</issn><eissn>1748-5460</eissn><coden>JLOTAX</coden><abstract>Neomycin was instilled daily, uni-or bilaterally, into the middle ear of guinea pigs for three months. The cochleae were examined, by light and electron microscopy, six months after the end of treatment. The organs of Corti of the treated ears were completely destroyed, and in the most advanced lesions, were substituted by a single layer of very thin flat cells. In the spiral ganglion only some glial cells and a few neurons could be observed. All surviving neurons were myelinated, and their ultrastructure was greatly altered, with disappeared, losing it amorphous and filamentous components. The spiral limbus and the stria vascularis were atrophic and were also covered, in the final stages, by flat elongated cells. In view of its morphological characteristics, this epithelium may arise from the displacement of the interdental cells and perhaps from the cochlear surface of Reissner's membrane.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>3385319</pmid><doi>10.1017/S0022215100104815</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of laryngology and otology, 1988-04, Vol.102 (4), p.304-307 |
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| source | MEDLINE; Cambridge University Press Journals Complete |
| subjects | Administration, Topical Animals Biological and medical sciences Cochlea - drug effects Cochlea - ultrastructure Drug Administration Schedule Drug toxicity and drugs side effects treatment Ear, Middle Guinea Pigs Main Articles Medical sciences Microscopy, Electron Miscellaneous (drug allergy, mutagens, teratogens...) Neomycin - administration & dosage Neomycin - adverse effects Pharmacology. Drug treatments |
| title | Long-term ototoxic effects of neomycin applied topically in the middle ear: A morphological study in the guinea pig |
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