Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats

This study examined the sites in the central nervous system at which subcutaneously-administered R(+) - baclofen hydrochloride (baclofen), the most active isomer of this prototypic γ-aminobutyric acid (GABAB receptor agonist, acts to produce antinociception in the rat. To determine whether baclofen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 1996-04, Vol.718 (1), p.129-137
Hauptverfasser:	Thomas, David A., Navarrete, Isabel M., Graham, Brent A., McGowan, Malcolm K., Hammond, Donna L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - antagonists & inhibitors Analgesics, Non-Narcotic - pharmacology Animals Antinociception Baclofen - administration & dosage Baclofen - antagonists & inhibitors Baclofen - pharmacology Basal Ganglia - drug effects Biological and medical sciences Catheterization CGP 35348 GABA GABA Antagonists - administration & dosage GABA Antagonists - pharmacology GABA B receptor GABA-B Receptor Antagonists Injections, Spinal Injections, Subcutaneous Male Medical sciences Medulla Oblongata - physiology Microinjections Neuropharmacology Nucleus raphe magnus Nucleus reticularis gigantocellularis pars α Organophosphorus Compounds - administration & dosage Organophosphorus Compounds - pharmacology Pain Measurement - drug effects Pharmacology. Drug treatments Raphe Nuclei - drug effects Rats Rats, Sprague-Dawley Reaction Time - drug effects Spinal Cord - physiology Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!