Restriction fragment analysis of duplication of the fourth component of complement (C4A)

The two genes encoding the fourth component of complement ( C4A and C4B) reside between HLA- B and HLA-DR on human chromosome 6. Two kilobases downstream from each C4 gene lies a 21-hydroxylase gene ( CA21HA and CA21HB, respectively). Utilizing the method of Southern blotting and a 5′-end 2.4-kb Bam...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1988, Vol.2 (1), p.76-85
Hauptverfasser:	McLean, Robert H., Donohoue, Patricia A., Jospe, Nicholas, Bias, Wilma B., Van Dop, Cornelis, Migeon, Claude J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Hyperplasia, Congenital - genetics Arthritis, Rheumatoid - genetics Child Chromosome Aberrations Chromosome Deletion Chromosome Disorders Complement C4 - genetics Complement C4a DNA Restriction Enzymes Female Genes Glomerulonephritis - genetics Haplotypes HLA Antigens - genetics Humans Lupus Erythematosus, Systemic - genetics Major Histocompatibility Complex Male Pedigree
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