Effects of endothelin A and B receptors on aqueous humor dynamics in the rabbit eye
This study attempted to clarify the role of endothelin A and B (ETA and ETB) receptors in modulating aqueous humor dynamics in the rabbit eye. Intraocular pressure (IOP), aqueous flow, total outflow facility, and uveoscleral outflow were measured before, and 24 hours after, intravitreal injection (2...
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| Veröffentlicht in: | Journal of ocular pharmacology and therapeutics 1996, Vol.12 (2), p.123-130 |
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| container_title | Journal of ocular pharmacology and therapeutics |
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| creator | TANIGUCHI, T MOHAMMAD SABBIR REZA HAQUE SUGIYAMA, K OKADA, K NAKAI, Y KITAZAWA, Y |
| description | This study attempted to clarify the role of endothelin A and B (ETA and ETB) receptors in modulating aqueous humor dynamics in the rabbit eye. Intraocular pressure (IOP), aqueous flow, total outflow facility, and uveoscleral outflow were measured before, and 24 hours after, intravitreal injection (20 microliters) of a selective ETB agonist, sarafotoxin S6c (SRTX S6c, 10(-5) M), into one eye and its vehicle into the contralateral eye. The measurements were also performed before and after injection of a selective ETA antagonist, 97-139 (10(-2) M) + ET-1 (10(-5) M) into one eye, and vehicle + ET-1 (10(-5) M) into the contralateral eye. In the SRTX S6c-treated eye, total outflow facility increased significantly by 106% compared with that in the vehicle-treated eye 24 hours after injection; aqueous flow and uveoscleral outflow failed to change significantly. The ETA antagonist 97-139 inhibited the decrease in aqueous flow partially, but significantly, but failed to inhibit the increase in total outflow facility caused by ET-1. Therefore, both ETA and ETB play a significant role in modulating aqueous humor dynamics in the rabbit eye. ETA can modulate aqueous humor production, at least in part. ETB can modulate total outflow facility, and the possibility for ETB in modulating aqueous humor formation cannot be ruled out. |
| doi_str_mv | 10.1089/jop.1996.12.123 |
| format | Article |
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Intraocular pressure (IOP), aqueous flow, total outflow facility, and uveoscleral outflow were measured before, and 24 hours after, intravitreal injection (20 microliters) of a selective ETB agonist, sarafotoxin S6c (SRTX S6c, 10(-5) M), into one eye and its vehicle into the contralateral eye. The measurements were also performed before and after injection of a selective ETA antagonist, 97-139 (10(-2) M) + ET-1 (10(-5) M) into one eye, and vehicle + ET-1 (10(-5) M) into the contralateral eye. In the SRTX S6c-treated eye, total outflow facility increased significantly by 106% compared with that in the vehicle-treated eye 24 hours after injection; aqueous flow and uveoscleral outflow failed to change significantly. The ETA antagonist 97-139 inhibited the decrease in aqueous flow partially, but significantly, but failed to inhibit the increase in total outflow facility caused by ET-1. Therefore, both ETA and ETB play a significant role in modulating aqueous humor dynamics in the rabbit eye. ETA can modulate aqueous humor production, at least in part. ETB can modulate total outflow facility, and the possibility for ETB in modulating aqueous humor formation cannot be ruled out.</description><identifier>ISSN: 1080-7683</identifier><identifier>EISSN: 1557-7732</identifier><identifier>DOI: 10.1089/jop.1996.12.123</identifier><identifier>PMID: 8773928</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>Animals ; Aqueous Humor - drug effects ; Aqueous Humor - metabolism ; Biological and medical sciences ; Caffeic Acids - pharmacology ; Dose-Response Relationship, Drug ; Endothelin Receptor Antagonists ; Eye and associated structures. Visual pathways and centers. Vision ; Female ; Fundamental and applied biological sciences. Psychology ; Intraocular Pressure - drug effects ; Intraocular Pressure - physiology ; Male ; Oleanolic Acid - analogs & derivatives ; Rabbits ; Receptor, Endothelin A ; Receptor, Endothelin B ; Receptors, Endothelin - physiology ; Time Factors ; Vasoconstrictor Agents - pharmacology ; Vertebrates: nervous system and sense organs ; Viper Venoms - pharmacology</subject><ispartof>Journal of ocular pharmacology and therapeutics, 1996, Vol.12 (2), p.123-130</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-e3f9c19f203b2fed78317f93054a117fc96de72ff3f23acaa17365d859f8cef43</citedby><cites>FETCH-LOGICAL-c321t-e3f9c19f203b2fed78317f93054a117fc96de72ff3f23acaa17365d859f8cef43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3029,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3205471$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8773928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TANIGUCHI, T</creatorcontrib><creatorcontrib>MOHAMMAD SABBIR REZA HAQUE</creatorcontrib><creatorcontrib>SUGIYAMA, K</creatorcontrib><creatorcontrib>OKADA, K</creatorcontrib><creatorcontrib>NAKAI, Y</creatorcontrib><creatorcontrib>KITAZAWA, Y</creatorcontrib><title>Effects of endothelin A and B receptors on aqueous humor dynamics in the rabbit eye</title><title>Journal of ocular pharmacology and therapeutics</title><addtitle>J Ocul Pharmacol Ther</addtitle><description>This study attempted to clarify the role of endothelin A and B (ETA and ETB) receptors in modulating aqueous humor dynamics in the rabbit eye. Intraocular pressure (IOP), aqueous flow, total outflow facility, and uveoscleral outflow were measured before, and 24 hours after, intravitreal injection (20 microliters) of a selective ETB agonist, sarafotoxin S6c (SRTX S6c, 10(-5) M), into one eye and its vehicle into the contralateral eye. The measurements were also performed before and after injection of a selective ETA antagonist, 97-139 (10(-2) M) + ET-1 (10(-5) M) into one eye, and vehicle + ET-1 (10(-5) M) into the contralateral eye. In the SRTX S6c-treated eye, total outflow facility increased significantly by 106% compared with that in the vehicle-treated eye 24 hours after injection; aqueous flow and uveoscleral outflow failed to change significantly. The ETA antagonist 97-139 inhibited the decrease in aqueous flow partially, but significantly, but failed to inhibit the increase in total outflow facility caused by ET-1. Therefore, both ETA and ETB play a significant role in modulating aqueous humor dynamics in the rabbit eye. ETA can modulate aqueous humor production, at least in part. ETB can modulate total outflow facility, and the possibility for ETB in modulating aqueous humor formation cannot be ruled out.</description><subject>Animals</subject><subject>Aqueous Humor - drug effects</subject><subject>Aqueous Humor - metabolism</subject><subject>Biological and medical sciences</subject><subject>Caffeic Acids - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endothelin Receptor Antagonists</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Intraocular Pressure - drug effects</subject><subject>Intraocular Pressure - physiology</subject><subject>Male</subject><subject>Oleanolic Acid - analogs & derivatives</subject><subject>Rabbits</subject><subject>Receptor, Endothelin A</subject><subject>Receptor, Endothelin B</subject><subject>Receptors, Endothelin - physiology</subject><subject>Time Factors</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Viper Venoms - pharmacology</subject><issn>1080-7683</issn><issn>1557-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kL1rwzAQxUVpSdO0c6eChtLNiaSLLWlMQ_oBgQ5tZyHLEnGwrVSyh_z3VYgJHNzB-93x7iH0SMmcEiEXe3-YUymLOWWp4ApNaZ7zjHNg12kmgmS8EHCL7mLcE0KBFHSCJiIBkokp-t44Z00fsXfYdpXvd7apO7zCuqvwKw7W2EPvQ9I7rP8G64eId0PrA66OnW5rE3HC0xYOuizrHtujvUc3TjfRPox9hn7fNj_rj2z79f65Xm0zA4z2mQUnDZWOESiZsxUXQLmTQPKlpmkysqgsZ86BY6CN1pRDkVcil04Y65YwQy_nu4fgk7XYq7aOxjaN7k4-FReMS05FAhdn0AQfY7BOHULd6nBUlKhTjCrFqE4xKspSQdp4Gk8PZWurCz_mlvTnUdfR6MYF3Zk6XjBg6QlO4R-8unrl</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>TANIGUCHI, T</creator><creator>MOHAMMAD SABBIR REZA HAQUE</creator><creator>SUGIYAMA, K</creator><creator>OKADA, K</creator><creator>NAKAI, Y</creator><creator>KITAZAWA, Y</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Effects of endothelin A and B receptors on aqueous humor dynamics in the rabbit eye</title><author>TANIGUCHI, T ; MOHAMMAD SABBIR REZA HAQUE ; SUGIYAMA, K ; OKADA, K ; NAKAI, Y ; KITAZAWA, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-e3f9c19f203b2fed78317f93054a117fc96de72ff3f23acaa17365d859f8cef43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Aqueous Humor - drug effects</topic><topic>Aqueous Humor - metabolism</topic><topic>Biological and medical sciences</topic><topic>Caffeic Acids - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endothelin Receptor Antagonists</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Intraocular Pressure - drug effects</topic><topic>Intraocular Pressure - physiology</topic><topic>Male</topic><topic>Oleanolic Acid - analogs & derivatives</topic><topic>Rabbits</topic><topic>Receptor, Endothelin A</topic><topic>Receptor, Endothelin B</topic><topic>Receptors, Endothelin - physiology</topic><topic>Time Factors</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Viper Venoms - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TANIGUCHI, T</creatorcontrib><creatorcontrib>MOHAMMAD SABBIR REZA HAQUE</creatorcontrib><creatorcontrib>SUGIYAMA, K</creatorcontrib><creatorcontrib>OKADA, K</creatorcontrib><creatorcontrib>NAKAI, Y</creatorcontrib><creatorcontrib>KITAZAWA, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ocular pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TANIGUCHI, T</au><au>MOHAMMAD SABBIR REZA HAQUE</au><au>SUGIYAMA, K</au><au>OKADA, K</au><au>NAKAI, Y</au><au>KITAZAWA, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of endothelin A and B receptors on aqueous humor dynamics in the rabbit eye</atitle><jtitle>Journal of ocular pharmacology and therapeutics</jtitle><addtitle>J Ocul Pharmacol Ther</addtitle><date>1996</date><risdate>1996</risdate><volume>12</volume><issue>2</issue><spage>123</spage><epage>130</epage><pages>123-130</pages><issn>1080-7683</issn><eissn>1557-7732</eissn><abstract>This study attempted to clarify the role of endothelin A and B (ETA and ETB) receptors in modulating aqueous humor dynamics in the rabbit eye. Intraocular pressure (IOP), aqueous flow, total outflow facility, and uveoscleral outflow were measured before, and 24 hours after, intravitreal injection (20 microliters) of a selective ETB agonist, sarafotoxin S6c (SRTX S6c, 10(-5) M), into one eye and its vehicle into the contralateral eye. The measurements were also performed before and after injection of a selective ETA antagonist, 97-139 (10(-2) M) + ET-1 (10(-5) M) into one eye, and vehicle + ET-1 (10(-5) M) into the contralateral eye. In the SRTX S6c-treated eye, total outflow facility increased significantly by 106% compared with that in the vehicle-treated eye 24 hours after injection; aqueous flow and uveoscleral outflow failed to change significantly. The ETA antagonist 97-139 inhibited the decrease in aqueous flow partially, but significantly, but failed to inhibit the increase in total outflow facility caused by ET-1. Therefore, both ETA and ETB play a significant role in modulating aqueous humor dynamics in the rabbit eye. ETA can modulate aqueous humor production, at least in part. ETB can modulate total outflow facility, and the possibility for ETB in modulating aqueous humor formation cannot be ruled out.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>8773928</pmid><doi>10.1089/jop.1996.12.123</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of ocular pharmacology and therapeutics, 1996, Vol.12 (2), p.123-130 |
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| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Animals Aqueous Humor - drug effects Aqueous Humor - metabolism Biological and medical sciences Caffeic Acids - pharmacology Dose-Response Relationship, Drug Endothelin Receptor Antagonists Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Intraocular Pressure - drug effects Intraocular Pressure - physiology Male Oleanolic Acid - analogs & derivatives Rabbits Receptor, Endothelin A Receptor, Endothelin B Receptors, Endothelin - physiology Time Factors Vasoconstrictor Agents - pharmacology Vertebrates: nervous system and sense organs Viper Venoms - pharmacology |
| title | Effects of endothelin A and B receptors on aqueous humor dynamics in the rabbit eye |
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