Selective expression of CD44 cell-adhesion molecule in thyroid papillary carcinoma fine-needle aspirates
Recent descriptions of numerous pitfalls in the cytologic diagnosis of thyroid papillary carcinoma on fine‐needle aspiration biopsy specimens have prompted studies of new ancillary diagnostic methods. We evaluated the potential use of immunocytochemical staining of thyroid fine‐needle aspiration bio...
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| Veröffentlicht in: | Diagnostic cytopathology 1996-06, Vol.14 (4), p.287-291 |
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| creator | Ross, Jeffrey S. del Rosario, Arthur D. Sanderson, Barbara Bui, Hai X. |
| description | Recent descriptions of numerous pitfalls in the cytologic diagnosis of thyroid papillary carcinoma on fine‐needle aspiration biopsy specimens have prompted studies of new ancillary diagnostic methods. We evaluated the potential use of immunocytochemical staining of thyroid fine‐needle aspiration biopsy specimens for CD44, a glycosylated cartilage link protein associated with extracellular matrix adhesion and lymphocyte homing. Fourteen of 16 (88%) classic, surgically confirmed, thyroid aspiration biopsies stained intensely positive for this marker, whereas 0 of 30 (0%) similarly‐processed benign aspirates from colloid nodules showed immunoreactivity for CD44 antigen. From this study, we conclude that most papillary carcinomas of the thyroid express the cell‐adhesion molecule CD44, which may be of clinical value in confirming the diagnosis on borderline fine‐needle aspiration specimens. Further study of CD44 expression may prove of significant interest in explaining the unusual mode of spread and clinical course of this disease. Diagn Cytopathol 1996;14:287–291. © 1996 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1097-0339(199605)14:4<287::AID-DC2>3.0.CO;2-D |
| format | Article |
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We evaluated the potential use of immunocytochemical staining of thyroid fine‐needle aspiration biopsy specimens for CD44, a glycosylated cartilage link protein associated with extracellular matrix adhesion and lymphocyte homing. Fourteen of 16 (88%) classic, surgically confirmed, thyroid aspiration biopsies stained intensely positive for this marker, whereas 0 of 30 (0%) similarly‐processed benign aspirates from colloid nodules showed immunoreactivity for CD44 antigen. From this study, we conclude that most papillary carcinomas of the thyroid express the cell‐adhesion molecule CD44, which may be of clinical value in confirming the diagnosis on borderline fine‐needle aspiration specimens. Further study of CD44 expression may prove of significant interest in explaining the unusual mode of spread and clinical course of this disease. Diagn Cytopathol 1996;14:287–291. © 1996 Wiley‐Liss, Inc.</description><identifier>ISSN: 8755-1039</identifier><identifier>EISSN: 1097-0339</identifier><identifier>DOI: 10.1002/(SICI)1097-0339(199605)14:4<287::AID-DC2>3.0.CO;2-D</identifier><identifier>PMID: 8725126</identifier><identifier>CODEN: DICYE7</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Biopsy, Needle ; Carcinoma, Papillary - immunology ; Carcinoma, Papillary - pathology ; CD44 ; Endocrinopathies ; Evaluation Studies as Topic ; Female ; fine-needle aspiration biopsy ; Humans ; Hyaluronan Receptors - analysis ; Immunohistochemistry ; Male ; Malignant tumors ; Medical sciences ; Middle Aged ; papillary carcinoma ; Prognosis ; Retrospective Studies ; thyroid ; Thyroid Neoplasms - immunology ; Thyroid Neoplasms - pathology ; Thyroid. Thyroid axis (diseases)</subject><ispartof>Diagnostic cytopathology, 1996-06, Vol.14 (4), p.287-291</ispartof><rights>Copyright © 1996 Wiley‐Liss, Inc.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4242-dc7b5f402d364b778a368dedb54cd82d79cc143a8e8b9b02f638deeb0c439af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0339%28199605%2914%3A4%3C287%3A%3AAID-DC2%3E3.0.CO%3B2-D$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0339%28199605%2914%3A4%3C287%3A%3AAID-DC2%3E3.0.CO%3B2-D$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,23930,23931,25140,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3106800$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8725126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ross, Jeffrey S.</creatorcontrib><creatorcontrib>del Rosario, Arthur D.</creatorcontrib><creatorcontrib>Sanderson, Barbara</creatorcontrib><creatorcontrib>Bui, Hai X.</creatorcontrib><title>Selective expression of CD44 cell-adhesion molecule in thyroid papillary carcinoma fine-needle aspirates</title><title>Diagnostic cytopathology</title><addtitle>Diagn. Cytopathol</addtitle><description>Recent descriptions of numerous pitfalls in the cytologic diagnosis of thyroid papillary carcinoma on fine‐needle aspiration biopsy specimens have prompted studies of new ancillary diagnostic methods. We evaluated the potential use of immunocytochemical staining of thyroid fine‐needle aspiration biopsy specimens for CD44, a glycosylated cartilage link protein associated with extracellular matrix adhesion and lymphocyte homing. Fourteen of 16 (88%) classic, surgically confirmed, thyroid aspiration biopsies stained intensely positive for this marker, whereas 0 of 30 (0%) similarly‐processed benign aspirates from colloid nodules showed immunoreactivity for CD44 antigen. From this study, we conclude that most papillary carcinomas of the thyroid express the cell‐adhesion molecule CD44, which may be of clinical value in confirming the diagnosis on borderline fine‐needle aspiration specimens. Further study of CD44 expression may prove of significant interest in explaining the unusual mode of spread and clinical course of this disease. Diagn Cytopathol 1996;14:287–291. © 1996 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Carcinoma, Papillary - immunology</subject><subject>Carcinoma, Papillary - pathology</subject><subject>CD44</subject><subject>Endocrinopathies</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>fine-needle aspiration biopsy</subject><subject>Humans</subject><subject>Hyaluronan Receptors - analysis</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>papillary carcinoma</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>thyroid</subject><subject>Thyroid Neoplasms - immunology</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><issn>8755-1039</issn><issn>1097-0339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF2L1DAUhoso67j6E4ReiOxedMxXm3ZWhKXVdXBxwFkUvDmk6SkT7ZdJR3f-vakd5mYvvArJ-_DmnCcIrihZUkLYm4vtOl9fUpLJiHCeXdAsS0h8ScVKvGWpXK2u10VU5OwdX5JlvrliUfEoWJz4x8EilXEcUcKzp8Ez534QQjJGk7PgLJUspixZBLstNqhH8xtDvB8sOmf6LuzrMC-ECDU2TaSqHf57bXuP7hsMTReOu4PtTRUOajBNo-wh1Mpq0_WtCmvTYdQhVh5VbjBWjeieB09q1Th8cTzPg7sP7-_yj9Ht5madX99GWjDBokrLMq4FYRVPRCllqniSVliVsdBVyiqZaU0FVymmZVYSVifcx1gSLXiman4evJ5rB9v_2qMboTVuWkN12O8dyJTJLOGxB7czqG3vnMUaBmtavwhQApN-gEk_TDph0gmzfqACBHj9AF4_eP3AgUC-AQaFb315_H5ftlidOo--ff7qmCunVVNb1WnjThinJEkJ8diXGftjGjw8mOw_gz2ca7r60mguNW7E-1Opsj8hkVzG8O3zDXz6yr6TPJ6a_wIoVbuE</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>Ross, Jeffrey S.</creator><creator>del Rosario, Arthur D.</creator><creator>Sanderson, Barbara</creator><creator>Bui, Hai X.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960601</creationdate><title>Selective expression of CD44 cell-adhesion molecule in thyroid papillary carcinoma fine-needle aspirates</title><author>Ross, Jeffrey S. ; del Rosario, Arthur D. ; Sanderson, Barbara ; Bui, Hai X.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4242-dc7b5f402d364b778a368dedb54cd82d79cc143a8e8b9b02f638deeb0c439af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Carcinoma, Papillary - immunology</topic><topic>Carcinoma, Papillary - pathology</topic><topic>CD44</topic><topic>Endocrinopathies</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>fine-needle aspiration biopsy</topic><topic>Humans</topic><topic>Hyaluronan Receptors - analysis</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>papillary carcinoma</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>thyroid</topic><topic>Thyroid Neoplasms - immunology</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ross, Jeffrey S.</creatorcontrib><creatorcontrib>del Rosario, Arthur D.</creatorcontrib><creatorcontrib>Sanderson, Barbara</creatorcontrib><creatorcontrib>Bui, Hai X.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic cytopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ross, Jeffrey S.</au><au>del Rosario, Arthur D.</au><au>Sanderson, Barbara</au><au>Bui, Hai X.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective expression of CD44 cell-adhesion molecule in thyroid papillary carcinoma fine-needle aspirates</atitle><jtitle>Diagnostic cytopathology</jtitle><addtitle>Diagn. Cytopathol</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>14</volume><issue>4</issue><spage>287</spage><epage>291</epage><pages>287-291</pages><issn>8755-1039</issn><eissn>1097-0339</eissn><coden>DICYE7</coden><abstract>Recent descriptions of numerous pitfalls in the cytologic diagnosis of thyroid papillary carcinoma on fine‐needle aspiration biopsy specimens have prompted studies of new ancillary diagnostic methods. We evaluated the potential use of immunocytochemical staining of thyroid fine‐needle aspiration biopsy specimens for CD44, a glycosylated cartilage link protein associated with extracellular matrix adhesion and lymphocyte homing. Fourteen of 16 (88%) classic, surgically confirmed, thyroid aspiration biopsies stained intensely positive for this marker, whereas 0 of 30 (0%) similarly‐processed benign aspirates from colloid nodules showed immunoreactivity for CD44 antigen. From this study, we conclude that most papillary carcinomas of the thyroid express the cell‐adhesion molecule CD44, which may be of clinical value in confirming the diagnosis on borderline fine‐needle aspiration specimens. Further study of CD44 expression may prove of significant interest in explaining the unusual mode of spread and clinical course of this disease. Diagn Cytopathol 1996;14:287–291. © 1996 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8725126</pmid><doi>10.1002/(SICI)1097-0339(199605)14:4<287::AID-DC2>3.0.CO;2-D</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Biopsy, Needle Carcinoma, Papillary - immunology Carcinoma, Papillary - pathology CD44 Endocrinopathies Evaluation Studies as Topic Female fine-needle aspiration biopsy Humans Hyaluronan Receptors - analysis Immunohistochemistry Male Malignant tumors Medical sciences Middle Aged papillary carcinoma Prognosis Retrospective Studies thyroid Thyroid Neoplasms - immunology Thyroid Neoplasms - pathology Thyroid. Thyroid axis (diseases) |
| title | Selective expression of CD44 cell-adhesion molecule in thyroid papillary carcinoma fine-needle aspirates |
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