Commentary: mannitol: molecule magnifique or a case of radical misinterpretation?

Commentary: mannitol: molecule magnifique or a case of radical misinterpretation?

Reactive oxygen species are constantly formed in biological systems. When production exceeds antioxidant protection, oxidative stress leading to molecular damage occurs. The most reactive ROS in biological systems is the hydroxyl radical which damages adjacent molecules at diffusion controlled rates...

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Veröffentlicht in:Free radical research 1996-01, Vol.24 (1), p.1-7
Hauptverfasser: Gillbe, C E, Sage, F J, Gutteridge, J M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Free Radical Scavengers - chemistry
Free Radicals
Humans
Mannitol - chemistry
Reactive Oxygen Species - chemistry
Reperfusion Injury
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container_title Free radical research
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creator Gillbe, C E
Sage, F J
Gutteridge, J M
description Reactive oxygen species are constantly formed in biological systems. When production exceeds antioxidant protection, oxidative stress leading to molecular damage occurs. The most reactive ROS in biological systems is the hydroxyl radical which damages adjacent molecules at diffusion controlled rates. The possibility of preventing such chemistry inside cells with therapeutic doses of mannitol at present seem remote.
doi_str_mv 10.3109/10715769609087994
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source MEDLINE; Taylor & Francis Journals Complete
subjects Animals
Free Radical Scavengers - chemistry
Free Radicals
Humans
Mannitol - chemistry
Reactive Oxygen Species - chemistry
Reperfusion Injury
title Commentary: mannitol: molecule magnifique or a case of radical misinterpretation?
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