Histologic evidence of absorption of sequestration-type herniated disc
The reactions to sequestrated disc fragments, which were removed surgically from 35 patients, were examined histologically. To elucidate whether or not there is histologic evidence of absorption of sequestrated discs. Spontaneous disappearance or diminution of lumbar herniated discs in the spinal ca...
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| Veröffentlicht in: | Spine (Philadelphia, Pa. 1976) Pa. 1976), 1996-01, Vol.21 (2), p.230-234 |
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| container_title | Spine (Philadelphia, Pa. 1976) |
| container_volume | 21 |
| creator | ITO, T YAMADA, M IKUTA, F FUKUDA, T HOSHI, S.-I KAWAJI, Y UCHIYAMA, S HOMMA, T TAKAHASHI, H. E |
| description | The reactions to sequestrated disc fragments, which were removed surgically from 35 patients, were examined histologically.
To elucidate whether or not there is histologic evidence of absorption of sequestrated discs.
Spontaneous disappearance or diminution of lumbar herniated discs in the spinal canal has been recognized, and this could be a possible explanation for relief of symptoms without surgery. The mechanism of this phenomenon is unclear.
Sequestrated discs removed surgically from 35 patients were examined histologically.
In 30 cases, neovascularization was observed at the periphery of the sequestrated discs. Many foamy cells (macrophages) were present in the vascularized areas. In addition, immunohistochemistry revealed that many spindle-shaped, fibroblast-like cells were positive for CD68, a marker of macrophages. No fibrous scar formation was observed in any region.
These findings suggest that organization is not a main course for this type of herniated disc and that a kind of "absorption" process occurs predominantly in the healing stage. |
| doi_str_mv | 10.1097/00007632-199601150-00014 |
| format | Article |
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To elucidate whether or not there is histologic evidence of absorption of sequestrated discs.
Spontaneous disappearance or diminution of lumbar herniated discs in the spinal canal has been recognized, and this could be a possible explanation for relief of symptoms without surgery. The mechanism of this phenomenon is unclear.
Sequestrated discs removed surgically from 35 patients were examined histologically.
In 30 cases, neovascularization was observed at the periphery of the sequestrated discs. Many foamy cells (macrophages) were present in the vascularized areas. In addition, immunohistochemistry revealed that many spindle-shaped, fibroblast-like cells were positive for CD68, a marker of macrophages. No fibrous scar formation was observed in any region.
These findings suggest that organization is not a main course for this type of herniated disc and that a kind of "absorption" process occurs predominantly in the healing stage.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/00007632-199601150-00014</identifier><identifier>PMID: 8720409</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott</publisher><subject>Adult ; Aged ; Antigens, CD - analysis ; Antigens, Differentiation, Myelomonocytic - analysis ; Biological and medical sciences ; Diseases of the osteoarticular system ; Diseases of the spine ; Female ; Foam Cells - immunology ; Foam Cells - pathology ; Humans ; Intervertebral Disc Displacement - pathology ; Lumbar Vertebrae - pathology ; Male ; Medical sciences ; Middle Aged ; Neovascularization, Pathologic - pathology ; Remission, Spontaneous</subject><ispartof>Spine (Philadelphia, Pa. 1976), 1996-01, Vol.21 (2), p.230-234</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-56efac2d7b8745ef531961c7751186f5cc61286f5f2c6d2fbb4c8b51ba735f9e3</citedby><cites>FETCH-LOGICAL-c339t-56efac2d7b8745ef531961c7751186f5cc61286f5f2c6d2fbb4c8b51ba735f9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2981138$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8720409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ITO, T</creatorcontrib><creatorcontrib>YAMADA, M</creatorcontrib><creatorcontrib>IKUTA, F</creatorcontrib><creatorcontrib>FUKUDA, T</creatorcontrib><creatorcontrib>HOSHI, S.-I</creatorcontrib><creatorcontrib>KAWAJI, Y</creatorcontrib><creatorcontrib>UCHIYAMA, S</creatorcontrib><creatorcontrib>HOMMA, T</creatorcontrib><creatorcontrib>TAKAHASHI, H. E</creatorcontrib><title>Histologic evidence of absorption of sequestration-type herniated disc</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>The reactions to sequestrated disc fragments, which were removed surgically from 35 patients, were examined histologically.
To elucidate whether or not there is histologic evidence of absorption of sequestrated discs.
Spontaneous disappearance or diminution of lumbar herniated discs in the spinal canal has been recognized, and this could be a possible explanation for relief of symptoms without surgery. The mechanism of this phenomenon is unclear.
Sequestrated discs removed surgically from 35 patients were examined histologically.
In 30 cases, neovascularization was observed at the periphery of the sequestrated discs. Many foamy cells (macrophages) were present in the vascularized areas. In addition, immunohistochemistry revealed that many spindle-shaped, fibroblast-like cells were positive for CD68, a marker of macrophages. No fibrous scar formation was observed in any region.
These findings suggest that organization is not a main course for this type of herniated disc and that a kind of "absorption" process occurs predominantly in the healing stage.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens, CD - analysis</subject><subject>Antigens, Differentiation, Myelomonocytic - analysis</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Diseases of the spine</subject><subject>Female</subject><subject>Foam Cells - immunology</subject><subject>Foam Cells - pathology</subject><subject>Humans</subject><subject>Intervertebral Disc Displacement - pathology</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Remission, Spontaneous</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0EKqXwCUhZIHYBP-LXElWUIlViA2vLcWwwSuNgp0j9e5w2dDYe37nz0AGgQPABQckfYQ7OCC6RlAwiRGGZFVSdgTmiWJRZkedgDgnDJa4IuwRXKX1nCyNIzsBMcAwrKOdgtfZpCG349Kawv76xnbFFcIWuU4j94EM3_pL92dk0RD0K5bDvbfFlY-f1YJui8clcgwun22RvpncBPlbP78t1uXl7eV0-bUpDiBxKyqzTBje8Fryi1tF8DUOGc4qQYI4awxAeE4cNa7Cr68qImqJac0KdtGQB7o9z-xgOJ6lt3m7bVnc27JLiAnNBKpyN4mg0MaQUrVN99Fsd9wpBNSJU_wjVCaE6IMytt9OOXb21zalxYpbrd1NdJ6NbF3VnfDrZsBQIEUH-AKLfeU8</recordid><startdate>19960115</startdate><enddate>19960115</enddate><creator>ITO, T</creator><creator>YAMADA, M</creator><creator>IKUTA, F</creator><creator>FUKUDA, T</creator><creator>HOSHI, S.-I</creator><creator>KAWAJI, Y</creator><creator>UCHIYAMA, S</creator><creator>HOMMA, T</creator><creator>TAKAHASHI, H. E</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960115</creationdate><title>Histologic evidence of absorption of sequestration-type herniated disc</title><author>ITO, T ; YAMADA, M ; IKUTA, F ; FUKUDA, T ; HOSHI, S.-I ; KAWAJI, Y ; UCHIYAMA, S ; HOMMA, T ; TAKAHASHI, H. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-56efac2d7b8745ef531961c7751186f5cc61286f5f2c6d2fbb4c8b51ba735f9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens, CD - analysis</topic><topic>Antigens, Differentiation, Myelomonocytic - analysis</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Diseases of the spine</topic><topic>Female</topic><topic>Foam Cells - immunology</topic><topic>Foam Cells - pathology</topic><topic>Humans</topic><topic>Intervertebral Disc Displacement - pathology</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Remission, Spontaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ITO, T</creatorcontrib><creatorcontrib>YAMADA, M</creatorcontrib><creatorcontrib>IKUTA, F</creatorcontrib><creatorcontrib>FUKUDA, T</creatorcontrib><creatorcontrib>HOSHI, S.-I</creatorcontrib><creatorcontrib>KAWAJI, Y</creatorcontrib><creatorcontrib>UCHIYAMA, S</creatorcontrib><creatorcontrib>HOMMA, T</creatorcontrib><creatorcontrib>TAKAHASHI, H. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ITO, T</au><au>YAMADA, M</au><au>IKUTA, F</au><au>FUKUDA, T</au><au>HOSHI, S.-I</au><au>KAWAJI, Y</au><au>UCHIYAMA, S</au><au>HOMMA, T</au><au>TAKAHASHI, H. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histologic evidence of absorption of sequestration-type herniated disc</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>1996-01-15</date><risdate>1996</risdate><volume>21</volume><issue>2</issue><spage>230</spage><epage>234</epage><pages>230-234</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>The reactions to sequestrated disc fragments, which were removed surgically from 35 patients, were examined histologically.
To elucidate whether or not there is histologic evidence of absorption of sequestrated discs.
Spontaneous disappearance or diminution of lumbar herniated discs in the spinal canal has been recognized, and this could be a possible explanation for relief of symptoms without surgery. The mechanism of this phenomenon is unclear.
Sequestrated discs removed surgically from 35 patients were examined histologically.
In 30 cases, neovascularization was observed at the periphery of the sequestrated discs. Many foamy cells (macrophages) were present in the vascularized areas. In addition, immunohistochemistry revealed that many spindle-shaped, fibroblast-like cells were positive for CD68, a marker of macrophages. No fibrous scar formation was observed in any region.
These findings suggest that organization is not a main course for this type of herniated disc and that a kind of "absorption" process occurs predominantly in the healing stage.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>8720409</pmid><doi>10.1097/00007632-199601150-00014</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0362-2436 |
| ispartof | Spine (Philadelphia, Pa. 1976), 1996-01, Vol.21 (2), p.230-234 |
| issn | 0362-2436 1528-1159 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78278342 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Antigens, CD - analysis Antigens, Differentiation, Myelomonocytic - analysis Biological and medical sciences Diseases of the osteoarticular system Diseases of the spine Female Foam Cells - immunology Foam Cells - pathology Humans Intervertebral Disc Displacement - pathology Lumbar Vertebrae - pathology Male Medical sciences Middle Aged Neovascularization, Pathologic - pathology Remission, Spontaneous |
| title | Histologic evidence of absorption of sequestration-type herniated disc |
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