Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4+ T cells precedes the development of tolerance in vivo

We have previously demonstrated that intranasal (i.n.) administration of an immunodominant peptide (p1 111–139) derived from the house dust mite (HDM) allergen Der p 1 inhibits antigenspecific CD4+ T cell responses in H-2b mice. Here we report that i.n. peptide induced a rapid but transient activati...

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