Solubilization of High‐Affinity, Guanine Nucleotide‐Sensitive μ‐Opioid Receptors from Rat Brain Membranes

: High‐affinity μ‐opioid receptors have been solubilized from rat brain membranes. In most experiments, rats were treated for 14 days with naltrexone to increase the density of opioid receptors in brain membranes. Occupancy of the membrane‐associated receptors with morphine during solubilization in...

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Veröffentlicht in:	Journal of neurochemistry 1996-03, Vol.66 (3), p.1042-1050
Hauptverfasser:	Weems, Henri B., Chalecka‐Franaszek, Elzbieta, Côté, Thomas E.
Format:	Artikel
Sprache:	eng
Schlagworte:	[3H][d‐Ala2,N‐Me‐Phe4,Gly‐ol5]‐enkephalin [3H]Diprenorphine Animals Binding, Competitive Biological and medical sciences Brain - metabolism Cell receptors Cell structures and functions Cholic Acids - pharmacology Detergents - pharmacology Diprenorphine - metabolism Enkephalin, Ala-MePhe-Gly Enkephalins - metabolism Fundamental and applied biological sciences. Psychology Guanine Nucleotides - pharmacology Membranes - metabolism Molecular and cellular biology Neuropeptide receptors Precipitin Tests Rats Rats, Inbred BUF Receptors, Opioid, mu - drug effects Receptors, Opioid, mu - metabolism Solubility Solubilization μ‐Opioid receptor
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