Preadipocyte differentiation blocked by prostaglandin stimulation of prostanoid FP2 receptor in murine 3T3‐L1 cells

Treatment of 3T3‐L1 preadipocytes with arachidonic acid resulted in a dose‐dependent inhibition of adipocyte differentiation. The cells failed to accumulate fat droplets and did not express stearoyl‐CoA desaturase 1 mRNA, a marker for late‐stage differentiation. The inhibition of differentiation was...

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Veröffentlicht in:	Differentiation (London) 1996-08, Vol.60 (4), p.203-210
Hauptverfasser:	Casimir, David A., Miller, Carolyn Wilson, Ntambi, J. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adipocytes - cytology Adipocytes - drug effects Animals Arachidonic Acid - antagonists & inhibitors Arachidonic Acid - pharmacology Biological and medical sciences Cell Differentiation - drug effects Cell differentiation, maturation, development, hematopoiesis Cell physiology Dexamethasone - pharmacology Dinoprost - pharmacology Dinoprostone - pharmacology Fundamental and applied biological sciences. Psychology Mice Molecular and cellular biology Prostaglandin D2 - pharmacology Prostaglandins - biosynthesis Prostaglandins F, Synthetic - pharmacology Receptors, Prostaglandin - drug effects Stem Cells - cytology Stem Cells - drug effects Stimulation, Chemical
Online-Zugang:	Volltext
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