Phenylamino-Pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC)

Phenylamino‐pyrimidines represent a novel class of inhibitors of the protein kinase C with a high degree of selectivity versus other serine/threonine and tyrosine kinases. Steady state kinetic analysis of N‐(3‐[1‐imidazolyl]‐phenyl)‐4‐(3‐pyridyl)‐2‐pyrimidinamine (5), which showed potent inhibitory...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 1996-07, Vol.329 (7), p.371-376
Hauptverfasser:	Zimmermann, Jürg, Caravatti, Giorgio, Mett, Helmut, Meyer, Thomas, Müller, Marcel, Lydon, Nicholas B., Fabbro, Doriano
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - chemistry Aniline Compounds - pharmacology anti proliferative effect Antineoplastic agents Biological and medical sciences Cell Division - drug effects Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General aspects Humans Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Medical sciences Pharmacology. Drug treatments phenylamino-pyrimidine protein kinase C Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Pyrimidines - chemistry Pyrimidines - pharmacology Signal transduction Substrate Specificity Tumor Cells, Cultured
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