Mechanisms of Desensitization and Resensitization of Proteinase-activated Receptor-2

Proteinase-activated receptor-2 (PAR-2) is a G-protein-coupled receptor that is expressed by intestinal epithelial cells, which are episodically exposed to pancreatic trypsin in the intestinal lumen. Trypsin cleaves PAR-2 to expose a tethered ligand, which irreversibly activates the receptor. Thus,...

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Veröffentlicht in:	The Journal of biological chemistry 1996-09, Vol.271 (36), p.22003-22016
Hauptverfasser:	Böhm, S K, Khitin, L M, Grady, E F, Aponte, G, Payan, D G, Bunnett, N W
Format:	Artikel
Sprache:	eng
Schlagworte:	Arsenicals - pharmacology Bradykinin - pharmacology Calcium - metabolism Calcium-Transporting ATPases - metabolism Cell Line Endocytosis Extracellular Space - metabolism Fluorescent Antibody Technique Humans Interleukin-8 - pharmacology Intestinal Mucosa - metabolism Kidney - metabolism Lysosomes - chemistry Microscopy, Confocal Protein Kinase C - metabolism Receptor, PAR-2 Receptors, Cell Surface - metabolism Terpenes - pharmacology Thapsigargin Trypsin - metabolism Type C Phospholipases - metabolism
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