Branching Tubulogenesis but Not Scatter of Madin-Darby Canine Kidney Cells Requires a Functional Grb2 Binding Site in the Met Receptor Tyrosine Kinase

Hepatocyte growth factor is a multifunctional cytokine that induces mitogenesis, motility, invasion, and branching tubulogenesis of several epithelial and endothelial cell lines in culture. The receptor for hepatocyte growth factor has been identified as the Met tyrosine kinase. To investigate the s...

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Veröffentlicht in:	The Journal of biological chemistry 1996-09, Vol.271 (36), p.22211-22217
Hauptverfasser:	Fournier, T M, Kamikura, D, Teng, K, Park, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Binding Sites Cell Line Chimera Dogs Electrophoresis, Polyacrylamide Gel GRB2 Adaptor Protein Hepatocyte Growth Factor - metabolism Kidney Tubules - cytology Kidney Tubules - enzymology Macrophage Colony-Stimulating Factor - pharmacology Morphogenesis Proteins - metabolism Proto-Oncogene Proteins c-met Receptor Protein-Tyrosine Kinases - metabolism Signal Transduction Structure-Activity Relationship Tyrosine - metabolism
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