Crystal structure of human dihydrofolate reductase complexed with folate

The crystal structure of recombinant human dihydrofolate reductase with folate bound in the active site has been determined and the structural model refined at 0.2‐nm resolution. Preliminary studies of the binding of the inhibitors methotrexate and trimethoprim to the human apoenzyme have been perfo...

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Veröffentlicht in:	European journal of biochemistry 1988-06, Vol.174 (2), p.377-385
Hauptverfasser:	OEFNER, Christian, D'ARCY, Allan, WINKLER, Fritz K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - drug effects Biological and medical sciences Catalysis crystal structure Crystalline structure Crystallography dihydrofolate reductase Enzyme Inhibitors - analysis folic acid Folic Acid - analysis Fourier Analysis Fundamental and applied biological sciences. Psychology Humans man Methotrexate - analysis Models, Molecular Molecular biophysics Protein Conformation Structure in molecular biology Tetrahydrofolate Dehydrogenase - analysis Trimethoprim - analysis X-Ray Diffraction
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