Inadequate function of sterile tw5/tw32 spermatozoa overcome by intracytoplasmic sperm injection
Mice carrying two t complementary haplotypes (tw5/tw32) are totally sterile. Their spermatozoa have poor motility and fertilize neither zone‐intact nor zona‐free oocytes, even though they are structurally indistinguishable from control (wild‐type) spermatozoa. However, when injected directly into oo...
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| Veröffentlicht in: | Molecular reproduction and development 1996-06, Vol.44 (2), p.230-233 |
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| container_title | Molecular reproduction and development |
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| creator | Kuretake, Shoji Maleszewski, Marek Tokumasu, Ako Fujimoto, Hirokazu Yanagimachi, Ryuzo |
| description | Mice carrying two t complementary haplotypes (tw5/tw32) are totally sterile. Their spermatozoa have poor motility and fertilize neither zone‐intact nor zona‐free oocytes, even though they are structurally indistinguishable from control (wild‐type) spermatozoa. However, when injected directly into oocytes, these infertile spermatozoa are able to participate in normal development. This suggests that infertility of tw5/tw32 male (spermatozoa) is more likely to be due to poor sperm‐oocyte interaction than to genetic incompetence of sperm nuclei. © 1996 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1098-2795(199606)44:2<230::AID-MRD12>3.0.CO;2-6 |
| format | Article |
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Their spermatozoa have poor motility and fertilize neither zone‐intact nor zona‐free oocytes, even though they are structurally indistinguishable from control (wild‐type) spermatozoa. However, when injected directly into oocytes, these infertile spermatozoa are able to participate in normal development. 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Physiology ; mouse ; sperm ; Sperm-Ovum Interactions - physiology ; Spermatozoa - physiology ; sterility ; thaplotype ; Vertebrates: reproduction</subject><ispartof>Molecular reproduction and development, 1996-06, Vol.44 (2), p.230-233</ispartof><rights>Copyright © 1996 Wiley‐Liss, Inc.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291098-2795%28199606%2944%3A2%3C230%3A%3AAID-MRD12%3E3.0.CO%3B2-6$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291098-2795%28199606%2944%3A2%3C230%3A%3AAID-MRD12%3E3.0.CO%3B2-6$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3116258$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9115721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuretake, Shoji</creatorcontrib><creatorcontrib>Maleszewski, Marek</creatorcontrib><creatorcontrib>Tokumasu, Ako</creatorcontrib><creatorcontrib>Fujimoto, Hirokazu</creatorcontrib><creatorcontrib>Yanagimachi, Ryuzo</creatorcontrib><title>Inadequate function of sterile tw5/tw32 spermatozoa overcome by intracytoplasmic sperm injection</title><title>Molecular reproduction and development</title><addtitle>Mol. Reprod. Dev</addtitle><description>Mice carrying two t complementary haplotypes (tw5/tw32) are totally sterile. Their spermatozoa have poor motility and fertilize neither zone‐intact nor zona‐free oocytes, even though they are structurally indistinguishable from control (wild‐type) spermatozoa. However, when injected directly into oocytes, these infertile spermatozoa are able to participate in normal development. This suggests that infertility of tw5/tw32 male (spermatozoa) is more likely to be due to poor sperm‐oocyte interaction than to genetic incompetence of sperm nuclei. © 1996 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fertilization in Vitro - methods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Infertility, Male</subject><subject>intracytoplasmic sperm injection</subject><subject>Male</subject><subject>Mammalian male genital system</subject><subject>Mice</subject><subject>Morphology. Physiology</subject><subject>mouse</subject><subject>sperm</subject><subject>Sperm-Ovum Interactions - physiology</subject><subject>Spermatozoa - physiology</subject><subject>sterility</subject><subject>thaplotype</subject><subject>Vertebrates: reproduction</subject><issn>1040-452X</issn><issn>1098-2795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kV1v0zAYhaMJNLaxn4CUC4S2i3T264_EBSaNjI2IQSUYW-9eXNeRMvLRxQml_Po5S9UrW-ccH9vvEwQfKZlQQuDs5GeWZqeUqCSCWIkTqpQk8pTzKXwARqbTi-wy-vbjksI5m5BJOnsPkdwLDnYnXgx7TiIuYP4qOHTugRCiVEL2g31FqYiBHgS_s1ov7WOvOxvmfW26oqnDJg9dZ9uitGG3FmfdmkHoVratdNf8b3TY_LWtaSobLjZhUXetNpuuWZXaVYUZg15-sM9lr4OXuS6dPd6uR8Gvq8-36ZfoZnadpRc3UeE_BpFJFGN8qaWJFaNL5V8qpbAcNFfaUkOFYkZSoQWLE7awOWXcaLACFMRmkbCj4N3Yu2qbx966DqvCGVuWurZN7zBOQCYJBx98sw32i8oucdUWlW43uB2J999ufe2MLvNW16ZwuxijVIIY7rsbY2s_ps3OpgQHejjAwwEFDihwhIecI6CHh54dPrNDhgTTmZflKPjiaCwuPIN_u2Ld_kEZs1jg_fdrvLuf3376mgDO2RPHf6Ev</recordid><startdate>199606</startdate><enddate>199606</enddate><creator>Kuretake, Shoji</creator><creator>Maleszewski, Marek</creator><creator>Tokumasu, Ako</creator><creator>Fujimoto, Hirokazu</creator><creator>Yanagimachi, Ryuzo</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199606</creationdate><title>Inadequate function of sterile tw5/tw32 spermatozoa overcome by intracytoplasmic sperm injection</title><author>Kuretake, Shoji ; Maleszewski, Marek ; Tokumasu, Ako ; Fujimoto, Hirokazu ; Yanagimachi, Ryuzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i1992-c89334da6c7931d9009665e42a49ae1c1593c615a53783bef134ca2e52927cb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fertilization in Vitro - methods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Infertility, Male</topic><topic>intracytoplasmic sperm injection</topic><topic>Male</topic><topic>Mammalian male genital system</topic><topic>Mice</topic><topic>Morphology. Physiology</topic><topic>mouse</topic><topic>sperm</topic><topic>Sperm-Ovum Interactions - physiology</topic><topic>Spermatozoa - physiology</topic><topic>sterility</topic><topic>thaplotype</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuretake, Shoji</creatorcontrib><creatorcontrib>Maleszewski, Marek</creatorcontrib><creatorcontrib>Tokumasu, Ako</creatorcontrib><creatorcontrib>Fujimoto, Hirokazu</creatorcontrib><creatorcontrib>Yanagimachi, Ryuzo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular reproduction and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuretake, Shoji</au><au>Maleszewski, Marek</au><au>Tokumasu, Ako</au><au>Fujimoto, Hirokazu</au><au>Yanagimachi, Ryuzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inadequate function of sterile tw5/tw32 spermatozoa overcome by intracytoplasmic sperm injection</atitle><jtitle>Molecular reproduction and development</jtitle><addtitle>Mol. Reprod. Dev</addtitle><date>1996-06</date><risdate>1996</risdate><volume>44</volume><issue>2</issue><spage>230</spage><epage>233</epage><pages>230-233</pages><issn>1040-452X</issn><eissn>1098-2795</eissn><coden>MREDEE</coden><abstract>Mice carrying two t complementary haplotypes (tw5/tw32) are totally sterile. Their spermatozoa have poor motility and fertilize neither zone‐intact nor zona‐free oocytes, even though they are structurally indistinguishable from control (wild‐type) spermatozoa. However, when injected directly into oocytes, these infertile spermatozoa are able to participate in normal development. 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| ispartof | Molecular reproduction and development, 1996-06, Vol.44 (2), p.230-233 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Animals Biological and medical sciences Female Fertilization in Vitro - methods Fundamental and applied biological sciences. Psychology Infertility, Male intracytoplasmic sperm injection Male Mammalian male genital system Mice Morphology. Physiology mouse sperm Sperm-Ovum Interactions - physiology Spermatozoa - physiology sterility thaplotype Vertebrates: reproduction |
| title | Inadequate function of sterile tw5/tw32 spermatozoa overcome by intracytoplasmic sperm injection |
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