Influence of Helicobacter pylori on gastric mucosal adaptation to naproxen in man
Our objective was to determine whether H. pylori influences gastric mucosal injury and adaptation caused by naproxen. Twenty-four healthy volunteers, 12 H. pylori-positive and 12 H. pylori-negative, were given a 28-day course of naproxen 500 mg twice a day. They were each gastroscoped to assess gast...
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| Veröffentlicht in: | Digestive diseases and sciences 1996-08, Vol.41 (8), p.1583-1588 |
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| container_title | Digestive diseases and sciences |
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| creator | LIPSCOMB, G. R WALLIS, N ARMSTRONG, G GOODMAN, M. J REES, W. D. W |
| description | Our objective was to determine whether H. pylori influences gastric mucosal injury and adaptation caused by naproxen. Twenty-four healthy volunteers, 12 H. pylori-positive and 12 H. pylori-negative, were given a 28-day course of naproxen 500 mg twice a day. They were each gastroscoped to assess gastric mucosal damage and mucosal blood flow before and at 1, 7, and 28 days during treatment. Maximal gastric mucosal damage (median grade + IQR) occurred during the first 24 hr in both groups and was of similar magnitude (H. pylori-positive: 2.5, 2.0-3.0 P < 0.01; H. pylori-negative: 2.0, 1.0-3.0 P < 0.01). This damage was associated with a fall in antral but not corpus mucosal blood flow. With continued NSAID administration, gastric damage resolved confirming adaptation (H. pylori-positive 1.0, 0-2.0, H. pylori-negative: 1.0, 0-1.0) and antral mucosal blood flow returned to baseline in both groups by day 28. These observations suggest that initial gastric mucosal injury is not influenced by H. pylori colonization and adaptation occurs regardless of its presence. |
| doi_str_mv | 10.1007/BF02087904 |
| format | Article |
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With continued NSAID administration, gastric damage resolved confirming adaptation (H. pylori-positive 1.0, 0-2.0, H. pylori-negative: 1.0, 0-1.0) and antral mucosal blood flow returned to baseline in both groups by day 28. These observations suggest that initial gastric mucosal injury is not influenced by H. pylori colonization and adaptation occurs regardless of its presence.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/BF02087904</identifier><identifier>PMID: 8769283</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adaptation, Physiological ; Adolescent ; Adult ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Drug Tolerance ; Gastric Mucosa - blood supply ; Gastric Mucosa - drug effects ; Gastric Mucosa - pathology ; Gastritis - microbiology ; Gastritis - pathology ; Helicobacter Infections - pathology ; Helicobacter pylori ; Human bacterial diseases ; Humans ; Infectious diseases ; Medical sciences ; Middle Aged ; Naproxen - pharmacology ; Regional Blood Flow - drug effects</subject><ispartof>Digestive diseases and sciences, 1996-08, Vol.41 (8), p.1583-1588</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3214923$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8769283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LIPSCOMB, G. 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This damage was associated with a fall in antral but not corpus mucosal blood flow. With continued NSAID administration, gastric damage resolved confirming adaptation (H. pylori-positive 1.0, 0-2.0, H. pylori-negative: 1.0, 0-1.0) and antral mucosal blood flow returned to baseline in both groups by day 28. These observations suggest that initial gastric mucosal injury is not influenced by H. pylori colonization and adaptation occurs regardless of its presence.</description><subject>Adaptation, Physiological</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Drug Tolerance</subject><subject>Gastric Mucosa - blood supply</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastritis - microbiology</subject><subject>Gastritis - pathology</subject><subject>Helicobacter Infections - pathology</subject><subject>Helicobacter pylori</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Naproxen - pharmacology</subject><subject>Regional Blood Flow - drug effects</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhoMo67p68S7kIN6qk6T56FEXdRcWRNBzmabpUkmT2rTg_nsLLsLADDwP7wtDyDWDewagH55egIPRBeQnZMmkFhmXypySJTA134ypc3KR0hcAFJqpBVkYrQpuxJK8b0PjJxeso7GhG-dbGyu0oxtof_BxaGkMdI9pHFpLu8nGhJ5ijf2IYzujMdKA_RB_XKBtoB2GS3LWoE_u6rhX5PPl-WO9yXZvr9v14y7bc1mMWVNxrgrkzTzONhotcFYrlFYUAEbkSjiplQWFdS1RClRcMbBVLgSI3IkVufvLndu_J5fGsmuTdd5jcHFKpTZcGWnELN4cxanqXF32Q9vhcCiPP5j57ZFjsuibAYNt078mOMsLLsQv0w5pqQ</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>LIPSCOMB, G. 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W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g259t-fb2269a2fa2fecf7ac021d6a5c390083463e576c06add5a53a62610cb433034e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adaptation, Physiological</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Drug Tolerance</topic><topic>Gastric Mucosa - blood supply</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastritis - microbiology</topic><topic>Gastritis - pathology</topic><topic>Helicobacter Infections - pathology</topic><topic>Helicobacter pylori</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Naproxen - pharmacology</topic><topic>Regional Blood Flow - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LIPSCOMB, G. R</creatorcontrib><creatorcontrib>WALLIS, N</creatorcontrib><creatorcontrib>ARMSTRONG, G</creatorcontrib><creatorcontrib>GOODMAN, M. J</creatorcontrib><creatorcontrib>REES, W. D. W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIPSCOMB, G. R</au><au>WALLIS, N</au><au>ARMSTRONG, G</au><au>GOODMAN, M. J</au><au>REES, W. D. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Helicobacter pylori on gastric mucosal adaptation to naproxen in man</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>41</volume><issue>8</issue><spage>1583</spage><epage>1588</epage><pages>1583-1588</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Our objective was to determine whether H. pylori influences gastric mucosal injury and adaptation caused by naproxen. Twenty-four healthy volunteers, 12 H. pylori-positive and 12 H. pylori-negative, were given a 28-day course of naproxen 500 mg twice a day. They were each gastroscoped to assess gastric mucosal damage and mucosal blood flow before and at 1, 7, and 28 days during treatment. Maximal gastric mucosal damage (median grade + IQR) occurred during the first 24 hr in both groups and was of similar magnitude (H. pylori-positive: 2.5, 2.0-3.0 P < 0.01; H. pylori-negative: 2.0, 1.0-3.0 P < 0.01). This damage was associated with a fall in antral but not corpus mucosal blood flow. With continued NSAID administration, gastric damage resolved confirming adaptation (H. pylori-positive 1.0, 0-2.0, H. pylori-negative: 1.0, 0-1.0) and antral mucosal blood flow returned to baseline in both groups by day 28. These observations suggest that initial gastric mucosal injury is not influenced by H. pylori colonization and adaptation occurs regardless of its presence.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>8769283</pmid><doi>10.1007/BF02087904</doi><tpages>6</tpages></addata></record> |
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| ispartof | Digestive diseases and sciences, 1996-08, Vol.41 (8), p.1583-1588 |
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| subjects | Adaptation, Physiological Adolescent Adult Anti-Inflammatory Agents, Non-Steroidal - pharmacology Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Drug Tolerance Gastric Mucosa - blood supply Gastric Mucosa - drug effects Gastric Mucosa - pathology Gastritis - microbiology Gastritis - pathology Helicobacter Infections - pathology Helicobacter pylori Human bacterial diseases Humans Infectious diseases Medical sciences Middle Aged Naproxen - pharmacology Regional Blood Flow - drug effects |
| title | Influence of Helicobacter pylori on gastric mucosal adaptation to naproxen in man |
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